C19BA_BACUH
ID C19BA_BACUH Reviewed; 682 AA.
AC O86170;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Pesticidal crystal protein Cry19Ba {ECO:0000303|PubMed:9704107};
DE AltName: Full=78 kDa crystal protein;
DE AltName: Full=Crystaline entomocidal protoxin;
DE AltName: Full=Insecticidal delta-endotoxin CryXIXB(a);
GN Name=cry19Ba {ECO:0000303|PubMed:9704107}; Synonyms=cryXIXB(a);
OS Bacillus thuringiensis subsp. higo.
OG Plasmid.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=132266;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=9704107; DOI=10.1016/s0723-2020(98)80022-2;
RA Hwang S.H., Saitoh H., Mizuki E., Higuchi K., Ohba M.;
RT "A novel class of mosquitocidal delta-endotoxin, Cry19B, encoded by a
RT Bacillus thuringiensis serovar higo gene.";
RL Syst. Appl. Microbiol. 21:179-184(1998).
CC -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC epithelial cells of mosquitos (Probable). Has larvicidal activity
CC against Culex pipiens molestus, but not to Anopheles stephensi.
CC {ECO:0000269|PubMed:9704107}.
CC -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC and is accumulated both as an inclusion and as part of the spore coat.
CC -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC terminus.
CC -!- MISCELLANEOUS: Encoded on an unnamed 110 kb plasmid.
CC {ECO:0000305|PubMed:9704107}.
CC -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR EMBL; D88381; BAA32397.1; -; Genomic_DNA.
DR AlphaFoldDB; O86170; -.
DR SMR; O86170; -.
DR PRIDE; O86170; -.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 1.20.190.10; -; 1.
DR Gene3D; 2.100.10.10; -; 1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR038979; Pest_crys.
DR InterPro; IPR005638; Pest_crys_C.
DR InterPro; IPR005639; Pest_crys_N.
DR InterPro; IPR036716; Pest_crys_N_sf.
DR InterPro; IPR001178; Pest_cryst_cen_dom.
DR InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR PANTHER; PTHR37003; PTHR37003; 1.
DR Pfam; PF03944; Endotoxin_C; 1.
DR Pfam; PF00555; Endotoxin_M; 1.
DR Pfam; PF03945; Endotoxin_N; 1.
DR SUPFAM; SSF49785; SSF49785; 1.
DR SUPFAM; SSF51096; SSF51096; 1.
DR SUPFAM; SSF56849; SSF56849; 1.
PE 2: Evidence at transcript level;
KW Plasmid; Sporulation; Toxin; Virulence.
FT CHAIN 1..682
FT /note="Pesticidal crystal protein Cry19Ba"
FT /id="PRO_0000174095"
SQ SEQUENCE 682 AA; 78491 MW; 5351EA63E2B042F7 CRC64;
MNSYQNKNEY EILDAKRNTC HMSNCYPKYP LANDPQMYLR NTHYKDWINM CEEASYASSG
PSQLFKVGGS IVAKILGMIP EVGPLLSWMV SLFWPTIEEK NTVWEDMIKY VANLLKQELT
NDTLNRATSN LSGLNESLNI YNRALAAWKQ NKNNFASGEL IRSYINDLHI LFTRDIQSDF
SLGGYETVLL PSYASAANLH LLLLRDVAIY GKELGYPSTD VEFYYNEQKY YTEKYSNYCV
NTYKSGLESK KQIGWSDFNR YRREMTLSVL DIVALFPLYD TGLYPSKDGK IHVKAELTRE
IYSDVINDHV YGLMVPYISF EHAESLYTRR PHAFTWLKGF RFVTNSINSW TFLSGGENRY
FLTHGEGTIY NGPFLGQDTE YGGTSSYIDI SNNSSIYNLW TKNYEWIYPW TDPVNITKIN
FSITDNSNSS ESIYGAERMN KPTVRTDFNF LLNRAGNGPT TYNDYNHILS YMLINGETFG
QKRHGYSFAF THSSVDRYNT IVPDKIVQIP AVKTNLVGAN IIKGPGHTGG DLLKLEYERF
LSLRIKLIAS MTFRIRIRYA SNISGQMMIN IGYQNPTYFN IIPTTSRDYT ELKFEDFQLV
DTSYIYSGGP SISSNTLWLD NFSNGPVIID KIEFIPLGIT LNQAQGYDTY DQNANGMYHQ
NYSNSGYNYN QEYNTYYQSY NN
