C19L1_DROME
ID C19L1_DROME Reviewed; 545 AA.
AC A1Z8J0; B6IDJ3; Q86NM0;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=CWF19-like protein 1 homolog;
GN ORFNames=CG7741;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Booth B.,
RA Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E.,
RA George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G.,
RA Miranda A., Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S.,
RA Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M.,
RA Celniker S.E.;
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the CWF19 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAO45198.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE013599; AAF58671.2; -; Genomic_DNA.
DR EMBL; BT004842; AAO45198.1; ALT_FRAME; mRNA.
DR EMBL; BT050433; ACJ13140.1; -; mRNA.
DR RefSeq; NP_610670.2; NM_136826.3.
DR AlphaFoldDB; A1Z8J0; -.
DR SMR; A1Z8J0; -.
DR IntAct; A1Z8J0; 4.
DR STRING; 7227.FBpp0087219; -.
DR PaxDb; A1Z8J0; -.
DR PRIDE; A1Z8J0; -.
DR DNASU; 36208; -.
DR EnsemblMetazoa; FBtr0088118; FBpp0087219; FBgn0033615.
DR GeneID; 36208; -.
DR KEGG; dme:Dmel_CG7741; -.
DR UCSC; CG7741-RA; d. melanogaster.
DR FlyBase; FBgn0033615; CG7741.
DR VEuPathDB; VectorBase:FBgn0033615; -.
DR eggNOG; KOG2476; Eukaryota.
DR GeneTree; ENSGT00940000156000; -.
DR InParanoid; A1Z8J0; -.
DR OrthoDB; 414028at2759; -.
DR PhylomeDB; A1Z8J0; -.
DR BioGRID-ORCS; 36208; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 36208; -.
DR PRO; PR:A1Z8J0; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0033615; Expressed in egg cell and 25 other tissues.
DR ExpressionAtlas; A1Z8J0; baseline and differential.
DR Genevisible; A1Z8J0; DM.
DR GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR GO; GO:0061632; F:RNA lariat debranching enzyme activator activity; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR Gene3D; 3.30.428.10; -; 1.
DR InterPro; IPR040194; Cwf19-like.
DR InterPro; IPR006768; Cwf19-like_C_dom-1.
DR InterPro; IPR006767; Cwf19-like_C_dom-2.
DR InterPro; IPR036265; HIT-like_sf.
DR PANTHER; PTHR12072; PTHR12072; 2.
DR Pfam; PF04677; CwfJ_C_1; 1.
DR Pfam; PF04676; CwfJ_C_2; 1.
DR SUPFAM; SSF54197; SSF54197; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..545
FT /note="CWF19-like protein 1 homolog"
FT /id="PRO_0000315647"
FT REGION 306..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..329
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 545 AA; 62154 MW; C31E61B921F3D449 CRC64;
MHQVGSTNMM KIQSIAQLSI TMDAGTKILV VGDVRGRFKQ LFQRVEQVNK KAGPFEILCC
VGDFFGEDKQ NEELIAYKNG FKHITVPTYI LGPNQREHEK YFENLTDGEI CTNLTYLGRR
GVYTLSSGVK IAYLSGLEAQ GTADSAGSEH EFTKADVIAV RNSCLVSKNC STEYRGVDVL
LTSQWPFGMQ EKENATASKL VSFLCREIKP RYHFCAINGT HYESAPFRMP KDETTQFELC
TRFISLAEVG NAEKAKYIYA LSLKPVDKSR LLDLAQKTTN EIPCPFIGLD LGGAIGKNDS
SENRQYFYDM DGGRRKRQGG DNNKRDKRPR IPQIEQDKCW FCLSSPDVEK HLIITVGEHF
YLALAKGPIN KHHVMILSTK HVPCAAQLSP DDWKELNKFK AALRKFFKTL GQVVCFTERH
YKSVHLQINA LAFEEGYAWK IKHSFEDKAE EFNLEFETLP ALDSEKMLPE MGPYFLAELP
DDSTLITRQM KHFPIHFARD VFCSENLLNC DEKVNWKDCL LDKDEEVAYV EDFRKAFAPF
DFTDD
