C19L1_MOUSE
ID C19L1_MOUSE Reviewed; 537 AA.
AC Q8CI33; E9QNL3; Q05CB7; Q3UT85; Q8C2J2;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=CWF19-like protein 1;
GN Name=Cwf19l1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Egg, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Liver, and Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Liver, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CI33-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CI33-2; Sequence=VSP_030589;
CC -!- SIMILARITY: Belongs to the CWF19 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH27553.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; AK088543; BAC40413.1; -; mRNA.
DR EMBL; AK139654; BAE24095.1; -; mRNA.
DR EMBL; AC125101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC027553; AAH27553.1; ALT_SEQ; mRNA.
DR EMBL; BC037640; AAH37640.1; -; mRNA.
DR CCDS; CCDS37995.1; -. [Q8CI33-1]
DR RefSeq; NP_001074546.1; NM_001081077.1. [Q8CI33-1]
DR RefSeq; XP_006527427.1; XM_006527364.2. [Q8CI33-2]
DR RefSeq; XP_006527428.1; XM_006527365.2.
DR RefSeq; XP_011245659.1; XM_011247357.2. [Q8CI33-2]
DR RefSeq; XP_011245660.1; XM_011247358.2. [Q8CI33-2]
DR RefSeq; XP_017173785.1; XM_017318296.1. [Q8CI33-2]
DR RefSeq; XP_017173786.1; XM_017318297.1. [Q8CI33-2]
DR AlphaFoldDB; Q8CI33; -.
DR SMR; Q8CI33; -.
DR BioGRID; 215403; 1.
DR STRING; 10090.ENSMUSP00000026218; -.
DR iPTMnet; Q8CI33; -.
DR PhosphoSitePlus; Q8CI33; -.
DR EPD; Q8CI33; -.
DR MaxQB; Q8CI33; -.
DR PaxDb; Q8CI33; -.
DR PeptideAtlas; Q8CI33; -.
DR PRIDE; Q8CI33; -.
DR ProteomicsDB; 265395; -. [Q8CI33-1]
DR ProteomicsDB; 265396; -. [Q8CI33-2]
DR Antibodypedia; 49159; 110 antibodies from 17 providers.
DR Ensembl; ENSMUST00000026218; ENSMUSP00000026218; ENSMUSG00000025200. [Q8CI33-1]
DR GeneID; 72502; -.
DR KEGG; mmu:72502; -.
DR UCSC; uc008hpj.1; mouse. [Q8CI33-1]
DR CTD; 55280; -.
DR MGI; MGI:1919752; Cwf19l1.
DR VEuPathDB; HostDB:ENSMUSG00000025200; -.
DR eggNOG; KOG2476; Eukaryota.
DR GeneTree; ENSGT00940000156000; -.
DR HOGENOM; CLU_019955_2_0_1; -.
DR InParanoid; Q8CI33; -.
DR OMA; VCPNLYF; -.
DR OrthoDB; 414028at2759; -.
DR PhylomeDB; Q8CI33; -.
DR TreeFam; TF105790; -.
DR BioGRID-ORCS; 72502; 9 hits in 73 CRISPR screens.
DR ChiTaRS; Cwf19l1; mouse.
DR PRO; PR:Q8CI33; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q8CI33; protein.
DR Bgee; ENSMUSG00000025200; Expressed in undifferentiated genital tubercle and 243 other tissues.
DR ExpressionAtlas; Q8CI33; baseline and differential.
DR Genevisible; Q8CI33; MM.
DR GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR GO; GO:0061632; F:RNA lariat debranching enzyme activator activity; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR InterPro; IPR040194; Cwf19-like.
DR InterPro; IPR006768; Cwf19-like_C_dom-1.
DR InterPro; IPR006767; Cwf19-like_C_dom-2.
DR InterPro; IPR036265; HIT-like_sf.
DR PANTHER; PTHR12072; PTHR12072; 2.
DR Pfam; PF04677; CwfJ_C_1; 1.
DR Pfam; PF04676; CwfJ_C_2; 1.
DR SUPFAM; SSF54197; SSF54197; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..537
FT /note="CWF19-like protein 1"
FT /id="PRO_0000315642"
FT REGION 297..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..315
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..138
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030589"
FT CONFLICT 83
FT /note="G -> D (in Ref. 3; AAH37640)"
FT /evidence="ECO:0000305"
FT CONFLICT 480
FT /note="I -> S (in Ref. 1; BAE24095)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 537 AA; 60193 MW; 656C45983028C3F1 CRC64;
MAQKPLRLLA CGDVEGKFDV LFNRVRTIQK KSGNFDLLLC VGNFFGSAQD AEWEEYKTGN
KKAPIQTYVL GANNEETANY FQGADGCELA ENITYLGRKG VFTGSSGLQI VYLSGTESLD
EPVPAHSFSP KDVSSLRTML CSASQFKGVD ILLTSPWPKY VGSFGNSSGE VDTKNCGSAL
ISSLAVSLKP RYHFAALEKS YYERLPYRNH VVLQESAQHA TRFIALANVG NPEKKKYLYA
FSIVPMKLMA VAELVKQPPD VTENPYRDSG KQAAGGKHIP APQEESACQF FFDLSEKQGR
KRPSTGRDTR PPHAKQPRKP PQPPGPCWFC LASPEVEKHL VVNIGTHCYL ALAKGGLSDD
HVLILPIGHY QSVVELSAEV VEEVEKYKAT LQRFFKSRGK RCVLFERNYR SHHLQLQVIP
VPLSCCATDD IKDAFITQAQ EQQIELLEIP EHSDIKQIAQ PGAAYFYVEL DTGEKLFHRI
KKNFPLQFGR EVLASEAILN IPEKADWRQC QTSKDEEEAL ARRFRKDFEP FDFTLDD
