C19L2_DROME
ID C19L2_DROME Reviewed; 687 AA.
AC Q9VXT5; Q95RI4;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=CWF19-like protein 2 homolog;
GN ORFNames=CG9213;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128 AND SER-130, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- SIMILARITY: Belongs to the CWF19 family. {ECO:0000305}.
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DR EMBL; AE014298; AAF48473.2; -; Genomic_DNA.
DR EMBL; AY061353; AAL28901.1; -; mRNA.
DR RefSeq; NP_001285277.1; NM_001298348.1.
DR RefSeq; NP_788910.1; NM_176737.3.
DR AlphaFoldDB; Q9VXT5; -.
DR SMR; Q9VXT5; -.
DR BioGRID; 58841; 4.
DR IntAct; Q9VXT5; 2.
DR STRING; 7227.FBpp0073887; -.
DR iPTMnet; Q9VXT5; -.
DR PaxDb; Q9VXT5; -.
DR PRIDE; Q9VXT5; -.
DR EnsemblMetazoa; FBtr0074071; FBpp0073887; FBgn0030655.
DR EnsemblMetazoa; FBtr0340348; FBpp0309306; FBgn0030655.
DR GeneID; 32490; -.
DR KEGG; dme:Dmel_CG9213; -.
DR UCSC; CG9213-RA; d. melanogaster.
DR FlyBase; FBgn0030655; CG9213.
DR VEuPathDB; VectorBase:FBgn0030655; -.
DR eggNOG; KOG2477; Eukaryota.
DR HOGENOM; CLU_015540_3_0_1; -.
DR InParanoid; Q9VXT5; -.
DR OMA; QFESGRE; -.
DR OrthoDB; 1407830at2759; -.
DR PhylomeDB; Q9VXT5; -.
DR BioGRID-ORCS; 32490; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 32490; -.
DR PRO; PR:Q9VXT5; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0030655; Expressed in egg chamber and 12 other tissues.
DR ExpressionAtlas; Q9VXT5; baseline and differential.
DR Genevisible; Q9VXT5; DM.
DR GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR Gene3D; 3.30.428.10; -; 1.
DR InterPro; IPR040194; Cwf19-like.
DR InterPro; IPR006768; Cwf19-like_C_dom-1.
DR InterPro; IPR006767; Cwf19-like_C_dom-2.
DR InterPro; IPR036265; HIT-like_sf.
DR PANTHER; PTHR12072; PTHR12072; 2.
DR Pfam; PF04677; CwfJ_C_1; 1.
DR Pfam; PF04676; CwfJ_C_2; 1.
DR SUPFAM; SSF54197; SSF54197; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..687
FT /note="CWF19-like protein 2 homolog"
FT /id="PRO_0000315652"
FT REGION 24..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 6..51
FT /evidence="ECO:0000255"
FT COILED 108..131
FT /evidence="ECO:0000255"
FT COILED 290..325
FT /evidence="ECO:0000255"
FT COILED 444..475
FT /evidence="ECO:0000255"
FT COMPBIAS 24..49
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..90
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..271
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 128
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 130
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
SQ SEQUENCE 687 AA; 78149 MW; 7376BABC9E18EE76 CRC64;
MSYIQFESGR EKDKARQELR EAREAMLQQA KERAELRGQR ERQKELRGEA DWMLPALAKK
LEKPAKKSKK NVSKHKSRSK SKSSKKSRKH RNSSSSSESS TSSSSSFSED EKERKRRKKK
SKRSRKESAS EDEWVEAPPP LAADNVTKKE PPQRDDWMTS ESLLLKTFSR ERKEPAKPNE
KAQQIDAYDP AKSGRELNPY WKSNGTGLPG FQKPQDDDER QAKPHSSSSA QGSSRGWRKP
GAKAPSPPRR SRSRSKSATS SDEEEEEAVQ QPKSRPSCLT DEQINELAGK AIKAELKGKK
ELAAELNQQL EAARKERAEF IASGESVRNA NTRPAKSKAS AEHVLLTKVD QSGNVRPLVQ
SGDPNESYGG RMGPKRGSKK VDTHVDGQRV RYFADDDRYD IKQMFEREKH ATAAEVNLQY
ADIVSKHKNP NDDLDDIFAD KVRKQISASD AEKREMQSAI REHEKLVATL DNCERCFDSA
KLDKQLLVSL GDKIYLSLPW YMGLQSGHCI LTTLQHVPCC TQLDEDAWEE ISNFRKALTR
MFAARRQDVV FYEIANKLHR RPHLSVHCIP IPASQGEMAP FYFKKAIEES EQEWCINKQL
VSLRQKSLRA AIPKGLPYVW VHFGMDSGFA HVIEDEDRFP ANFAQEILGG MLELNPNAWR
KPRKEANPIG KVKSFAENWK KFDCTQN
