ID   TRPF_ACICA              Reviewed;         213 AA.
AC   P16923;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=N-(5'-phosphoribosyl)anthranilate isomerase;
DE            Short=PRAI;
DE            EC=5.3.1.24;
GN   Name=trpF;
OS   Acinetobacter calcoaceticus.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC   Acinetobacter; Acinetobacter calcoaceticus/baumannii complex.
OX   NCBI_TaxID=471;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2299982; DOI=10.1093/oxfordjournals.molbev.a040587;
RA   Ross C.M., Kaplan J.B., Winkler M.E., Nichols B.P.;
RT   "An evolutionary comparison of Acinetobacter calcoaceticus trpF with trpF
RT   genes of several organisms.";
RL   Mol. Biol. Evol. 7:74-81(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2211532; DOI=10.1128/jb.172.10.6151-6155.1990;
RA   Kishan V., Hillen W.;
RT   "Molecular cloning, nucleotide sequence, and promoter structure of the
RT   Acinetobacter calcoaceticus trpFB operon.";
RL   J. Bacteriol. 172:6151-6155(1990).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-
CC         carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate;
CC         Xref=Rhea:RHEA:21540, ChEBI:CHEBI:18277, ChEBI:CHEBI:58613;
CC         EC=5.3.1.24;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 3/5.
CC   -!- SIMILARITY: Belongs to the TrpF family. {ECO:0000305}.
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DR   EMBL; M34485; AAA21897.1; -; Genomic_DNA.
DR   EMBL; M58444; AAA21901.1; -; Genomic_DNA.
DR   PIR; A34091; A34091.
DR   AlphaFoldDB; P16923; -.
DR   SMR; P16923; -.
DR   PRIDE; P16923; -.
DR   UniPathway; UPA00035; UER00042.
DR   GO; GO:0004640; F:phosphoribosylanthranilate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00405; PRAI; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00135; PRAI; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001240; PRAI_dom.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   InterPro; IPR044643; TrpF_fam.
DR   PANTHER; PTHR42894; PTHR42894; 1.
DR   Pfam; PF00697; PRAI; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Isomerase;
KW   Tryptophan biosynthesis.
FT   CHAIN           1..213
FT                   /note="N-(5'-phosphoribosyl)anthranilate isomerase"
FT                   /id="PRO_0000154339"
SQ   SEQUENCE   213 AA;  23005 MW;  2AD64715EC59A02B CRC64;
     MRTRAKICGI TRSQDVQAAV SAGADAIGLV FFPPSPRHVS IAQAQALLQH IPAYVQVVGL
     FVNATADQIK SVLDCVALDV LQLHGDETPE QCQEIALQCK RRWYKAIQVK PELDVVDEVQ
     RYQAAGASAV LLDAWHPELK GGTGHQFDWS KFPKLDIPLI LAGGLTPENV VDAIQTTHAF
     AVDVSGGVEA AKGIKDKQLI ERFMQGVQCG SAK