TRPF_AERPE
ID TRPF_AERPE Reviewed; 215 AA.
AC Q9Y8T6;
DT 25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=N-(5'-phosphoribosyl)anthranilate isomerase;
DE Short=PRAI;
DE EC=5.3.1.24;
GN Name=trpF; OrderedLocusNames=APE_2547;
OS Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 /
OS K1).
OC Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC Desulfurococcaceae; Aeropyrum.
OX NCBI_TaxID=272557;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1;
RX PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K.,
RA Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A.,
RA Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S.,
RA Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.;
RT "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon,
RT Aeropyrum pernix K1.";
RL DNA Res. 6:83-101(1999).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-
CC carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate;
CC Xref=Rhea:RHEA:21540, ChEBI:CHEBI:18277, ChEBI:CHEBI:58613;
CC EC=5.3.1.24;
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 3/5.
CC -!- SIMILARITY: Belongs to the TrpF family. {ECO:0000305}.
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DR EMBL; BA000002; BAA81564.1; -; Genomic_DNA.
DR PIR; D72488; D72488.
DR AlphaFoldDB; Q9Y8T6; -.
DR SMR; Q9Y8T6; -.
DR STRING; 272557.APE_2547; -.
DR EnsemblBacteria; BAA81564; BAA81564; APE_2547.
DR KEGG; ape:APE_2547; -.
DR PATRIC; fig|272557.25.peg.1691; -.
DR eggNOG; arCOG01983; Archaea.
DR OMA; VKICGVA; -.
DR UniPathway; UPA00035; UER00042.
DR Proteomes; UP000002518; Chromosome.
DR GO; GO:0004640; F:phosphoribosylanthranilate isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00135; PRAI; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR001240; PRAI_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR Pfam; PF00697; PRAI; 1.
DR SUPFAM; SSF51366; SSF51366; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Isomerase;
KW Reference proteome; Tryptophan biosynthesis.
FT CHAIN 1..215
FT /note="N-(5'-phosphoribosyl)anthranilate isomerase"
FT /id="PRO_0000154397"
SQ SEQUENCE 215 AA; 22622 MW; EB30A27AEACC51E8 CRC64;
MVKVKICGVK KLESALQLDG LVDYIGFVHS LLGGPRSVPL EAARIMASQI EKSKTVLVVH
GSSPSYAAAA ADGFDVLQYH EPLLPSSAAS LQATLDPLGV TLAVVVEYTG SAWKPQEPCG
YINELNKEGV EPEYILLDTT KGLRDRIPLN EAAKASRCSH RVGLAGGLTP RDACKAVETG
VSLIDVSRGV ETGVPGVKDP LLSAELIMGA KRCSS