C19L2_MOUSE
ID C19L2_MOUSE Reviewed; 887 AA.
AC Q8BG79; Q3TIS8; Q3UX04; Q80XN7; Q8BZV5; Q8C0F8;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=CWF19-like protein 2;
GN Name=Cwf19l2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J;
RC TISSUE=Colon, Corpora quadrigemina, Egg, Placenta, Testis, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Eye, and Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-622, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BG79-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BG79-2; Sequence=VSP_030594, VSP_030595;
CC -!- SIMILARITY: Belongs to the CWF19 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC28298.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAE39768.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK031423; BAC27397.1; -; mRNA.
DR EMBL; AK033457; BAC28298.1; ALT_INIT; mRNA.
DR EMBL; AK045423; BAC32358.1; -; mRNA.
DR EMBL; AK083386; BAC38896.1; -; mRNA.
DR EMBL; AK135981; BAE22760.1; -; mRNA.
DR EMBL; AK167727; BAE39768.1; ALT_INIT; mRNA.
DR EMBL; BC043480; AAH43480.1; -; mRNA.
DR EMBL; BC125483; AAI25484.1; -; mRNA.
DR EMBL; BC125485; AAI25486.1; -; mRNA.
DR CCDS; CCDS22793.1; -. [Q8BG79-1]
DR RefSeq; NP_081821.1; NM_027545.2. [Q8BG79-1]
DR AlphaFoldDB; Q8BG79; -.
DR SMR; Q8BG79; -.
DR BioGRID; 232677; 7.
DR IntAct; Q8BG79; 1.
DR STRING; 10090.ENSMUSP00000027027; -.
DR iPTMnet; Q8BG79; -.
DR PhosphoSitePlus; Q8BG79; -.
DR EPD; Q8BG79; -.
DR jPOST; Q8BG79; -.
DR MaxQB; Q8BG79; -.
DR PaxDb; Q8BG79; -.
DR PeptideAtlas; Q8BG79; -.
DR PRIDE; Q8BG79; -.
DR ProteomicsDB; 273721; -. [Q8BG79-1]
DR ProteomicsDB; 273722; -. [Q8BG79-2]
DR Antibodypedia; 50383; 40 antibodies from 15 providers.
DR DNASU; 244672; -.
DR Ensembl; ENSMUST00000027027; ENSMUSP00000027027; ENSMUSG00000025898. [Q8BG79-1]
DR GeneID; 244672; -.
DR KEGG; mmu:244672; -.
DR UCSC; uc009oaz.1; mouse. [Q8BG79-2]
DR UCSC; uc009oba.1; mouse. [Q8BG79-1]
DR CTD; 143884; -.
DR MGI; MGI:1918023; Cwf19l2.
DR VEuPathDB; HostDB:ENSMUSG00000025898; -.
DR eggNOG; KOG2477; Eukaryota.
DR GeneTree; ENSGT00940000155627; -.
DR HOGENOM; CLU_015540_0_0_1; -.
DR InParanoid; Q8BG79; -.
DR OMA; FMKCLTR; -.
DR OrthoDB; 1407830at2759; -.
DR PhylomeDB; Q8BG79; -.
DR TreeFam; TF351271; -.
DR BioGRID-ORCS; 244672; 10 hits in 72 CRISPR screens.
DR ChiTaRS; Cwf19l2; mouse.
DR PRO; PR:Q8BG79; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8BG79; protein.
DR Bgee; ENSMUSG00000025898; Expressed in manus and 227 other tissues.
DR Genevisible; Q8BG79; MM.
DR GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR Gene3D; 3.30.428.10; -; 1.
DR InterPro; IPR040194; Cwf19-like.
DR InterPro; IPR006768; Cwf19-like_C_dom-1.
DR InterPro; IPR006767; Cwf19-like_C_dom-2.
DR InterPro; IPR036265; HIT-like_sf.
DR PANTHER; PTHR12072; PTHR12072; 1.
DR Pfam; PF04677; CwfJ_C_1; 1.
DR Pfam; PF04676; CwfJ_C_2; 1.
DR SUPFAM; SSF54197; SSF54197; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Isopeptide bond; Phosphoprotein;
KW Reference proteome; Ubl conjugation.
FT CHAIN 1..887
FT /note="CWF19-like protein 2"
FT /id="PRO_0000315649"
FT REGION 1..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 11..103
FT /evidence="ECO:0000255"
FT COILED 164..254
FT /evidence="ECO:0000255"
FT COILED 495..524
FT /evidence="ECO:0000255"
FT COMPBIAS 11..73
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..98
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..143
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..429
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 71
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q2TBE0"
FT MOD_RES 354
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q2TBE0"
FT MOD_RES 366
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q2TBE0"
FT MOD_RES 478
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q2TBE0"
FT MOD_RES 622
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CROSSLNK 168
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q2TBE0"
FT CROSSLNK 597
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q2TBE0"
FT VAR_SEQ 474..484
FT /note="PEAESTYILNV -> YFMYMCFHIDS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030594"
FT VAR_SEQ 485..887
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030595"
FT CONFLICT 340
FT /note="Q -> R (in Ref. 1; BAC27397)"
FT /evidence="ECO:0000305"
FT CONFLICT 594
FT /note="D -> E (in Ref. 1; BAC28298)"
FT /evidence="ECO:0000305"
FT CONFLICT 649
FT /note="S -> N (in Ref. 1; BAE39768)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 887 AA; 103173 MW; B99189E817110ED1 CRC64;
MEAFSVRFES ASSIEERKEQ TRNARAEVLR QAKHNFEKEQ RGEERKRLRD EDTWMLPDVH
ERIEQFSQEH SEKKKKKKDK HSKKVKKEKK KKRKKQKCQK QSESTDSSAS SEDEWVEAAP
SQISDKEKTW KVKDKRTEEE CDSHDIQRDE WMTIDFMSIK TVSSSSLKAE KETLRQIERE
KTQVLEQSKL LERELNPYWK DGGTGLPSKT CILPVTKAKG VEDGGLSWLR KSCQRMKEQA
QKENRNFEDI VAEKYGSMEI FQSKLKEAEK IAYKKEDCGW ERWRKPTYSD RAQCSQASGT
SDLVKCKNLS EDRHLEMEPA NSSNYKFSGP DTGKRSGTLQ TCRRESALRK NQDSSGNLRS
KFLRPSDEDE LSFHKRKNFE SSSSYSPLVA QASLHCDFRK LTENSEESSA SCSRSDRRQE
NRKPSDKKPL ETWSYNANQH STGGRREQLQ AESMSCDPPG RGLQQDMTLT IAGPEAESTY
ILNVDEKNKL GAKIIKAEMM GNMELAEQLK AQLKEANKFK ETQMPAKRLG VEHEDEQEVI
LIQTDKSGRM WPVSSPRETL DMKAERRKRK RVSTHEDKER VRYFPDDDHL SLKDLVKNEK
IGTDINQNRL FMKMASKFMG KSDEDNYTLD DMFVSKAAEK EHLGKKEESQ RRRAIAEHQS
LAAKMAKCLY CFDSSQFPKH LIVAIGVKVY LCLPSFQSLT EGHCFIVPLQ HHQAATVLDE
DVWEEIQMFR KSLVKMFEDK ELDCIFLETN MGLKKHYHMV YECIPLPKEV GDMAPIYFKK
AIMESDEEWS MNKKLIDLSS KDIRKSVPRG LPYFAVDFGL QGGFAHIIED QYRFPHYFGK
EIIGGMLDLE PRLWRKGIRE SFEDQRKKSL QFAQWWKPYD ITKSKSS
