ID   TRPF_CANAL              Reviewed;         226 AA.
AC   P43073; A0A1D8PC52; Q5AB75;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 2.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=N-(5'-phosphoribosyl)anthranilate isomerase;
DE            Short=PRAI;
DE            EC=5.3.1.24;
GN   Name=TRP1; OrderedLocusNames=CAALFM_C100120CA;
GN   ORFNames=CaO19.13515, CaO19.6096;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=7958943; DOI=10.1016/0378-1119(94)90687-4;
RA   Ostrander D.B., Gorman J.A.;
RT   "Characterization of the Candida albicans TRP1 gene and construction of a
RT   homozygous trp1 mutant by sequential co-transformation.";
RL   Gene 148:179-185(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-
CC         carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate;
CC         Xref=Rhea:RHEA:21540, ChEBI:CHEBI:18277, ChEBI:CHEBI:58613;
CC         EC=5.3.1.24;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 3/5.
CC   -!- SIMILARITY: Belongs to the TrpF family. {ECO:0000305}.
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DR   EMBL; X78466; CAA55217.1; -; Genomic_DNA.
DR   EMBL; CP017623; AOW25714.1; -; Genomic_DNA.
DR   RefSeq; XP_719055.1; XM_713962.1.
DR   AlphaFoldDB; P43073; -.
DR   SMR; P43073; -.
DR   STRING; 237561.P43073; -.
DR   GeneID; 3639321; -.
DR   KEGG; cal:CAALFM_C100120CA; -.
DR   CGD; CAL0000186853; TRP1.
DR   VEuPathDB; FungiDB:C1_00120C_A; -.
DR   eggNOG; KOG4202; Eukaryota.
DR   HOGENOM; CLU_076364_1_0_1; -.
DR   InParanoid; P43073; -.
DR   OMA; FYAKSPR; -.
DR   OrthoDB; 1536911at2759; -.
DR   UniPathway; UPA00035; UER00042.
DR   PRO; PR:P43073; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0004640; F:phosphoribosylanthranilate isomerase activity; IGI:CGD.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IMP:CGD.
DR   CDD; cd00405; PRAI; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00135; PRAI; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001240; PRAI_dom.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   InterPro; IPR044643; TrpF_fam.
DR   PANTHER; PTHR42894; PTHR42894; 1.
DR   Pfam; PF00697; PRAI; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Isomerase;
KW   Reference proteome; Tryptophan biosynthesis.
FT   CHAIN           1..226
FT                   /note="N-(5'-phosphoribosyl)anthranilate isomerase"
FT                   /id="PRO_0000154330"
FT   CONFLICT        160
FT                   /note="G -> S (in Ref. 1; CAA55217)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        206..208
FT                   /note="NGV -> SGA (in Ref. 1; CAA55217)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        216
FT                   /note="K -> Q (in Ref. 1; CAA55217)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        220..226
FT                   /note="KGHAQSS -> QAHSLI (in Ref. 1; CAA55217)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   226 AA;  24768 MW;  384C76FAD3AAB12A CRC64;
     MKVVKICGIK TVEAASVAID NGANLLGCIL VPNRARTIDL EVAKQIARMV KRDRNPPPKF
     AGGTSTQHFE QVAQWIIENG PFLVGVFRNQ PKEEVFRIAR EVGLDFIQLH GSEDKLEFLG
     TEFGLIPRYV VPDELDLLEE QSLSLTQCVS LPLLDSEVGG EGKLLDWTFI EKLPTKAILA
     GGLTPENLPT FDNILGYDVS GGVETNGVKD SLKIIKFIQK GHAQSS