ID   TRPF_CANGA              Reviewed;         217 AA.
AC   P50857; Q8NJS9;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   31-AUG-2004, sequence version 2.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=N-(5'-phosphoribosyl)anthranilate isomerase;
DE            Short=PRAI;
DE            EC=5.3.1.24;
GN   Name=TRP1; OrderedLocusNames=CAGL0C04092g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=8522176; DOI=10.1016/0378-1119(95)00552-h;
RA   Kitada K., Yamaguchi E., Arisawa M.;
RT   "Cloning of the Candida glabrata TRP1 and HIS3 genes, and construction of
RT   their disruptant strains by sequential integrative transformation.";
RL   Gene 165:203-206(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=12093907; DOI=10.1073/pnas.142101099;
RA   Wong S., Butler G., Wolfe K.H.;
RT   "Gene order evolution and paleopolyploidy in hemiascomycete yeasts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:9272-9277(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-
CC         carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate;
CC         Xref=Rhea:RHEA:21540, ChEBI:CHEBI:18277, ChEBI:CHEBI:58613;
CC         EC=5.3.1.24;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 3/5.
CC   -!- SIMILARITY: Belongs to the TrpF family. {ECO:0000305}.
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DR   EMBL; U31471; AAC49146.1; -; Genomic_DNA.
DR   EMBL; AF520060; AAM74212.1; -; Genomic_DNA.
DR   EMBL; CR380949; CAG58259.1; -; Genomic_DNA.
DR   PIR; JC4380; JC4380.
DR   RefSeq; XP_445353.1; XM_445353.1.
DR   AlphaFoldDB; P50857; -.
DR   SMR; P50857; -.
DR   STRING; 5478.XP_445353.1; -.
DR   EnsemblFungi; CAG58259; CAG58259; CAGL0C04092g.
DR   GeneID; 2886909; -.
DR   KEGG; cgr:CAGL0C04092g; -.
DR   CGD; CAL0127496; TRP1.
DR   VEuPathDB; FungiDB:CAGL0C04092g; -.
DR   eggNOG; KOG4202; Eukaryota.
DR   HOGENOM; CLU_076364_1_0_1; -.
DR   InParanoid; P50857; -.
DR   OMA; FYAKSPR; -.
DR   UniPathway; UPA00035; UER00042.
DR   Proteomes; UP000002428; Chromosome C.
DR   GO; GO:0004640; F:phosphoribosylanthranilate isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IMP:CGD.
DR   CDD; cd00405; PRAI; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00135; PRAI; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001240; PRAI_dom.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   InterPro; IPR044643; TrpF_fam.
DR   PANTHER; PTHR42894; PTHR42894; 1.
DR   Pfam; PF00697; PRAI; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Isomerase;
KW   Reference proteome; Tryptophan biosynthesis.
FT   CHAIN           1..217
FT                   /note="N-(5'-phosphoribosyl)anthranilate isomerase"
FT                   /id="PRO_0000154331"
FT   CONFLICT        147..149
FT                   /note="GEK -> VKE (in Ref. 1; AAC49146)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   217 AA;  23830 MW;  BF4AD8B89AF81184 CRC64;
     MSFDSLLDKN DKLVKVCGIQ TVEAAETALQ AGADLIGIIC VPNRKRTIES AVAREISKLI
     HKSGTTKLVG VFRNQSVEDV HRLSEEYDLD IIQLHGDESW PEYYNVIKKP IIKRVIFPRD
     VDVVTQVCQR KPLVCLPLFD SEAGGTGEKL DWSSISSWAS EQNNVFYILA GGLTAENVME
     AVGLPGVIGV DVSGGVETDG VKDNDKIIKY VQNAKKQ