ID   TRPF_HALSA              Reviewed;         218 AA.
AC   Q9HPG4;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=N-(5'-phosphoribosyl)anthranilate isomerase;
DE            Short=PRAI;
DE            EC=5.3.1.24;
GN   Name=trpF; OrderedLocusNames=VNG_1648G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-
CC         carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate;
CC         Xref=Rhea:RHEA:21540, ChEBI:CHEBI:18277, ChEBI:CHEBI:58613;
CC         EC=5.3.1.24;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 3/5.
CC   -!- SIMILARITY: Belongs to the TrpF family. {ECO:0000305}.
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DR   EMBL; AE004437; AAG19903.1; -; Genomic_DNA.
DR   PIR; C84317; C84317.
DR   RefSeq; WP_010903201.1; NC_002607.1.
DR   AlphaFoldDB; Q9HPG4; -.
DR   SMR; Q9HPG4; -.
DR   STRING; 64091.VNG_1648G; -.
DR   PaxDb; Q9HPG4; -.
DR   EnsemblBacteria; AAG19903; AAG19903; VNG_1648G.
DR   GeneID; 5954433; -.
DR   KEGG; hal:VNG_1648G; -.
DR   PATRIC; fig|64091.14.peg.1256; -.
DR   HOGENOM; CLU_076364_2_1_2; -.
DR   InParanoid; Q9HPG4; -.
DR   OMA; FYAKSPR; -.
DR   OrthoDB; 117266at2157; -.
DR   PhylomeDB; Q9HPG4; -.
DR   UniPathway; UPA00035; UER00042.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0004640; F:phosphoribosylanthranilate isomerase activity; IBA:GO_Central.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IBA:GO_Central.
DR   CDD; cd00405; PRAI; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00135; PRAI; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001240; PRAI_dom.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   InterPro; IPR044643; TrpF_fam.
DR   PANTHER; PTHR42894; PTHR42894; 1.
DR   Pfam; PF00697; PRAI; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Isomerase;
KW   Reference proteome; Tryptophan biosynthesis.
FT   CHAIN           1..218
FT                   /note="N-(5'-phosphoribosyl)anthranilate isomerase"
FT                   /id="PRO_0000154400"
SQ   SEQUENCE   218 AA;  21903 MW;  2F916B7E1E10B7F3 CRC64;
     MTRVKVCGLT TERDHAAAVA AGADAVGIIA DVPVETPREV SVETATALRA ATPPFVTSVL
     VTMPATPEHA VDLVRTVAPD AVQLHGDLPV GDAAYVAANT PCPVIKAVTA GDQSAARYAD
     VVDALLVDSP PTDDAGAGGG TGRTHDWAAT RAFADRVDTP VVLAGGLTPA NVADAVDTVD
     PFAVDVASGV EARPGEKDHA AVSAFVARAT ATPDPTLT