ID   TRPF_HALVD              Reviewed;         221 AA.
AC   P52563; D4GT39;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=N-(5'-phosphoribosyl)anthranilate isomerase;
DE            Short=PRAI;
DE            EC=5.3.1.24;
GN   Name=trpF; OrderedLocusNames=HVO_2455;
OS   Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 /
OS   NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Haloferacaceae; Haloferax.
OX   NCBI_TaxID=309800;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DS2 / DSM 5716 / WFD11;
RX   PubMed=1537810; DOI=10.1128/jb.174.5.1694-1697.1992;
RA   Lam W.L., Logan S.M., Doolittle W.F.;
RT   "Genes for tryptophan biosynthesis in the halophilic archaebacterium
RT   Haloferax volcanii: the trpDFEG cluster.";
RL   J. Bacteriol. 174:1694-1697(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM
RC   B-1768 / DS2;
RX   PubMed=20333302; DOI=10.1371/journal.pone.0009605;
RA   Hartman A.L., Norais C., Badger J.H., Delmas S., Haldenby S., Madupu R.,
RA   Robinson J., Khouri H., Ren Q., Lowe T.M., Maupin-Furlow J.,
RA   Pohlschroder M., Daniels C., Pfeiffer F., Allers T., Eisen J.A.;
RT   "The complete genome sequence of Haloferax volcanii DS2, a model
RT   archaeon.";
RL   PLoS ONE 5:E9605-E9605(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-
CC         carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate;
CC         Xref=Rhea:RHEA:21540, ChEBI:CHEBI:18277, ChEBI:CHEBI:58613;
CC         EC=5.3.1.24;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 3/5.
CC   -!- SIMILARITY: Belongs to the TrpF family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M83788; AAA73176.1; -; Genomic_DNA.
DR   EMBL; CP001956; ADE04719.1; -; Genomic_DNA.
DR   RefSeq; WP_004042369.1; NC_013967.1.
DR   AlphaFoldDB; P52563; -.
DR   SMR; P52563; -.
DR   STRING; 309800.C498_07575; -.
DR   EnsemblBacteria; ADE04719; ADE04719; HVO_2455.
DR   GeneID; 8924041; -.
DR   KEGG; hvo:HVO_2455; -.
DR   eggNOG; arCOG01983; Archaea.
DR   HOGENOM; CLU_076364_2_1_2; -.
DR   OMA; FYAKSPR; -.
DR   OrthoDB; 117266at2157; -.
DR   UniPathway; UPA00035; UER00042.
DR   Proteomes; UP000008243; Chromosome.
DR   GO; GO:0004640; F:phosphoribosylanthranilate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00405; PRAI; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00135; PRAI; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001240; PRAI_dom.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   InterPro; IPR044643; TrpF_fam.
DR   PANTHER; PTHR42894; PTHR42894; 1.
DR   Pfam; PF00697; PRAI; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Isomerase;
KW   Reference proteome; Tryptophan biosynthesis.
FT   CHAIN           1..221
FT                   /note="N-(5'-phosphoribosyl)anthranilate isomerase"
FT                   /id="PRO_0000154401"
SQ   SEQUENCE   221 AA;  22634 MW;  396453808C71FBAD CRC64;
     MTRVKVCGVT DETDLAAVDA AGADAVGAIC DVPVDTPREI PRERARELFA AAPPFLTTTL
     VTMPDSVDHA RDLAREVGPD VLQLHGDFAA DDLDSLRATG VGVVPVVDAT DLARARDLAP
     VVDAILVDTP SDSGAGGTGE THDWDASRDL VAAVDAPVIL AGGLTPDNVV EAVRTVEPYG
     VDVASGVEAS GGVKDHDAVR AFVAAAKTAR GAVDDHEEVV A