ID   C1GLC_BOVIN             Reviewed;         318 AA.
AC   Q3SX46;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=C1GALT1-specific chaperone 1;
GN   Name=C1GALT1C1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable chaperone required for the generation of 1 O-glycan
CC       Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for
CC       many extended O-glycans in glycoproteins. Probably acts as a specific
CC       molecular chaperone assisting the folding/stability of core 1 beta-3-
CC       galactosyltransferase (C1GALT1) (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associates with core 1 beta-3-galactosyltransferase (C1GALT1),
CC       probably not with the soluble active form. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 31 family. Beta3-Gal-T
CC       subfamily. {ECO:0000305}.
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DR   EMBL; BC104496; AAI04497.1; -; mRNA.
DR   RefSeq; NP_001029747.1; NM_001034575.1.
DR   RefSeq; XP_005227521.1; XM_005227464.3.
DR   RefSeq; XP_015316903.1; XM_015461417.1.
DR   AlphaFoldDB; Q3SX46; -.
DR   SMR; Q3SX46; -.
DR   STRING; 9913.ENSBTAP00000028542; -.
DR   CAZy; GT31; Glycosyltransferase Family 31.
DR   PaxDb; Q3SX46; -.
DR   PRIDE; Q3SX46; -.
DR   Ensembl; ENSBTAT00000028542; ENSBTAP00000028542; ENSBTAG00000021410.
DR   GeneID; 531644; -.
DR   KEGG; bta:531644; -.
DR   CTD; 29071; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021410; -.
DR   eggNOG; KOG2246; Eukaryota.
DR   GeneTree; ENSGT00940000155145; -.
DR   HOGENOM; CLU_874237_0_0_1; -.
DR   InParanoid; Q3SX46; -.
DR   OMA; CIIMVQP; -.
DR   OrthoDB; 1407357at2759; -.
DR   TreeFam; TF317293; -.
DR   Reactome; R-BTA-913709; O-linked glycosylation of mucins.
DR   Proteomes; UP000009136; Chromosome X.
DR   Bgee; ENSBTAG00000021410; Expressed in caput epididymis and 105 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016263; F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity; IBA:GO_Central.
DR   GO; GO:0016267; P:O-glycan processing, core 1; IBA:GO_Central.
DR   InterPro; IPR026731; C1GALT1C1.
DR   PANTHER; PTHR23033:SF2; PTHR23033:SF2; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..318
FT                   /note="C1GALT1-specific chaperone 1"
FT                   /id="PRO_0000285073"
FT   TOPO_DOM        1..6
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        7..26
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        27..318
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   318 AA;  36441 MW;  503202E70EA79C96 CRC64;
     MLSESSSFLK GVMLGSIFCA LITMLGHIRI GHGSRMHHHE HHHLQAPNKE DILKISEDER
     MELSKSFRVY CILLVRPKDV SLWAAVKETW TNHCDKVDFF SSENVKVFES INMETNDMWL
     MMRKAYKYAF DKYRDQYNWF FLARPTTFAI IENLKYFLLK KDPSQPFYLG HTVKSGDLEY
     VSMEGGIVLS IESMKRLNSL LSIPEKCPEQ GGMIWKISED KQLAVCLKYA GVFAENAEDS
     EGKDIFNTKS VGLFIKEAMT NHPNQVVEGC CSDMAVTFNG LTPNQMHVMM YGVYRLRAFG
     HVFNDALVFL PPNGSDND