ID   TRPF_LACCA              Reviewed;         199 AA.
AC   P17218;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=N-(5'-phosphoribosyl)anthranilate isomerase;
DE            Short=PRAI;
DE            EC=5.3.1.24;
GN   Name=trpF;
OS   Lactobacillus casei.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lacticaseibacillus.
OX   NCBI_TaxID=1582;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2113923; DOI=10.1093/oxfordjournals.jbchem.a123034;
RA   Natori Y., Kano Y., Imamoto F.;
RT   "Nucleotide sequences and genomic constitution of five tryptophan genes of
RT   Lactobacillus casei.";
RL   J. Biochem. 107:248-255(1990).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-
CC         carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate;
CC         Xref=Rhea:RHEA:21540, ChEBI:CHEBI:18277, ChEBI:CHEBI:58613;
CC         EC=5.3.1.24;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 3/5.
CC   -!- SIMILARITY: Belongs to the TrpF family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D00496; BAA00385.1; -; Genomic_DNA.
DR   PIR; S42345; JS0342.
DR   RefSeq; WP_003562637.1; NZ_JDWK01000136.1.
DR   AlphaFoldDB; P17218; -.
DR   SMR; P17218; -.
DR   STRING; 543734.LCABL_00740; -.
DR   PATRIC; fig|1582.48.peg.474; -.
DR   eggNOG; COG0135; Bacteria.
DR   UniPathway; UPA00035; UER00042.
DR   GO; GO:0004640; F:phosphoribosylanthranilate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00405; PRAI; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00135; PRAI; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001240; PRAI_dom.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   InterPro; IPR044643; TrpF_fam.
DR   PANTHER; PTHR42894; PTHR42894; 1.
DR   Pfam; PF00697; PRAI; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Isomerase;
KW   Tryptophan biosynthesis.
FT   CHAIN           1..199
FT                   /note="N-(5'-phosphoribosyl)anthranilate isomerase"
FT                   /id="PRO_0000154358"
SQ   SEQUENCE   199 AA;  21404 MW;  5B53A405E10B41A4 CRC64;
     MVLVKICGLM HSEDILAVNT AGADFAGFVF APGRHQVSLE QALALNQLLH SKIKTVGVFV
     NEPVAEILAI YQAGAIDVAQ LHGKSTPAEI TQLQQAGLKV IQVFERQAID LTSMADYLMV
     DSGKGSGQLL NLKAIPHISR PLILAGGLTP LNVRQAVQLV QPTMVDVSSG VETNGHKDAD
     KITQFIQQAK EDIIYEDIK