ID   TRPF_METAR              Reviewed;         213 AA.
AC   Q0W628;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=N-(5'-phosphoribosyl)anthranilate isomerase {ECO:0000255|HAMAP-Rule:MF_00135};
DE            Short=PRAI {ECO:0000255|HAMAP-Rule:MF_00135};
DE            EC=5.3.1.24 {ECO:0000255|HAMAP-Rule:MF_00135};
GN   Name=trpF {ECO:0000255|HAMAP-Rule:MF_00135}; OrderedLocusNames=UNCMA_20230;
GN   ORFNames=RCIX795;
OS   Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanocellales; Methanocellaceae; Methanocella.
OX   NCBI_TaxID=351160;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22066 / NBRC 105507 / MRE50;
RX   PubMed=16857943; DOI=10.1126/science.1127062;
RA   Erkel C., Kube M., Reinhardt R., Liesack W.;
RT   "Genome of rice cluster I archaea -- the key methane producers in the rice
RT   rhizosphere.";
RL   Science 313:370-372(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-
CC         carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate;
CC         Xref=Rhea:RHEA:21540, ChEBI:CHEBI:18277, ChEBI:CHEBI:58613;
CC         EC=5.3.1.24; Evidence={ECO:0000255|HAMAP-Rule:MF_00135};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 3/5. {ECO:0000255|HAMAP-
CC       Rule:MF_00135}.
CC   -!- SIMILARITY: Belongs to the TrpF family. {ECO:0000255|HAMAP-
CC       Rule:MF_00135}.
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DR   EMBL; AM114193; CAJ36165.1; -; Genomic_DNA.
DR   RefSeq; WP_012036346.1; NC_009464.1.
DR   AlphaFoldDB; Q0W628; -.
DR   SMR; Q0W628; -.
DR   STRING; 351160.RCIX795; -.
DR   EnsemblBacteria; CAJ36165; CAJ36165; RCIX795.
DR   GeneID; 5145424; -.
DR   KEGG; rci:RCIX795; -.
DR   PATRIC; fig|351160.9.peg.2076; -.
DR   eggNOG; arCOG01983; Archaea.
DR   OMA; FYAKSPR; -.
DR   OrthoDB; 117266at2157; -.
DR   UniPathway; UPA00035; UER00042.
DR   Proteomes; UP000000663; Chromosome.
DR   GO; GO:0004640; F:phosphoribosylanthranilate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00405; PRAI; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00135; PRAI; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001240; PRAI_dom.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   InterPro; IPR044643; TrpF_fam.
DR   PANTHER; PTHR42894; PTHR42894; 1.
DR   Pfam; PF00697; PRAI; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Isomerase;
KW   Reference proteome; Tryptophan biosynthesis.
FT   CHAIN           1..213
FT                   /note="N-(5'-phosphoribosyl)anthranilate isomerase"
FT                   /id="PRO_1000018647"
SQ   SEQUENCE   213 AA;  22774 MW;  E35D1BD9081733F2 CRC64;
     MTRVKICGTT TPEDALACAV SGADAIGMLV DVRISPRCIT ADQARLITSV LPPFVASVIV
     MQPSTPGEVV DAVRKIRPTA VQLHGSEPPD FLKHIKLQVP GVRLIKTIHV GEGGEIEKAR
     QYEGVADAIL LDTASARGGG MGITHDWNVS REIIGSVRLP VILAGGLSPK NVAEAIEAAR
     PYAVDVCSGV EAEKRKKDLR LVREFIEQVR VTK