TRPF_METTH
ID TRPF_METTH Reviewed; 241 AA.
AC O27695;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=N-(5'-phosphoribosyl)anthranilate isomerase;
DE Short=PRAI;
DE EC=5.3.1.24;
GN Name=trpF; OrderedLocusNames=MTH_1658;
OS Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX NCBI_TaxID=187420;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA Reeve J.N.;
RT "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT functional analysis and comparative genomics.";
RL J. Bacteriol. 179:7135-7155(1997).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-
CC carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate;
CC Xref=Rhea:RHEA:21540, ChEBI:CHEBI:18277, ChEBI:CHEBI:58613;
CC EC=5.3.1.24;
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 3/5.
CC -!- SIMILARITY: Belongs to the TrpF family. {ECO:0000305}.
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DR EMBL; AE000666; AAB86130.1; -; Genomic_DNA.
DR PIR; F69088; F69088.
DR RefSeq; WP_010877266.1; NC_000916.1.
DR AlphaFoldDB; O27695; -.
DR SMR; O27695; -.
DR STRING; 187420.MTH_1658; -.
DR EnsemblBacteria; AAB86130; AAB86130; MTH_1658.
DR GeneID; 1470743; -.
DR KEGG; mth:MTH_1658; -.
DR PATRIC; fig|187420.15.peg.1620; -.
DR HOGENOM; CLU_076364_2_0_2; -.
DR OMA; DCLDFNS; -.
DR UniPathway; UPA00035; UER00042.
DR Proteomes; UP000005223; Chromosome.
DR GO; GO:0004640; F:phosphoribosylanthranilate isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd00405; PRAI; 1.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00135; PRAI; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR001240; PRAI_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR InterPro; IPR044643; TrpF_fam.
DR PANTHER; PTHR42894; PTHR42894; 1.
DR Pfam; PF00697; PRAI; 1.
DR SUPFAM; SSF51366; SSF51366; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Isomerase;
KW Reference proteome; Tryptophan biosynthesis.
FT CHAIN 1..241
FT /note="N-(5'-phosphoribosyl)anthranilate isomerase"
FT /id="PRO_0000154407"
SQ SEQUENCE 241 AA; 25926 MW; 3CB027196E8729DD CRC64;
MNSSHESLAD VLVKICGIKR PEDAILADKL GADLLGLIHV ERSPRHLTGR ELEDILSLIP
PEKAVIVLEP SDPVEVAEVI ERTGVERVQL HSISCEDARG IKRVLTENGF NPGITVAVPP
EPGSLDVLDH IPCSCVMLDS SSGGRTGGTG RMIPPELALG MLRLIRSHES APEVALAGGL
GPSTVRLNPE YLLEFDCLDF NSGIEAAPGI KDHAMMFELM EYMGRTGGLQ KPSRLQRGEL
S