C1GLT_BOVIN
ID C1GLT_BOVIN Reviewed; 368 AA.
AC Q0VC84;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1;
DE EC=2.4.1.122 {ECO:0000250|UniProtKB:Q9NS00};
DE AltName: Full=Core 1 O-glycan T-synthase;
DE AltName: Full=Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1;
DE AltName: Full=Core 1 beta1,3-galactosyltransferase 1;
DE Short=C1GalT1;
DE Short=Core 1 beta3-Gal-T1;
GN Name=C1GALT1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Placenta;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Glycosyltransferase that generates the core 1 O-glycan Gal-
CC beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many
CC extended O-glycans in glycoproteins. Plays a central role in many
CC processes, such as angiogenesis, thrombopoiesis and kidney homeostasis
CC development (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-
CC galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-
CC galactosaminyl derivative + H(+) + UDP; Xref=Rhea:RHEA:15621,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:28257, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:66914, ChEBI:CHEBI:133470; EC=2.4.1.122;
CC Evidence={ECO:0000250|UniProtKB:Q9NS00};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC -!- SUBUNIT: Homodimer; disulfide-linked. Interacts with the C1GALT1C1
CC chaperone; required for galactosyltransferase activity (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 31 family. Beta3-Gal-T
CC subfamily. {ECO:0000305}.
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DR EMBL; BC120299; AAI20300.1; -; mRNA.
DR RefSeq; NP_001069628.1; NM_001076160.2.
DR RefSeq; XP_005205216.1; XM_005205159.3.
DR RefSeq; XP_015323642.1; XM_015468156.1.
DR AlphaFoldDB; Q0VC84; -.
DR SMR; Q0VC84; -.
DR STRING; 9913.ENSBTAP00000006571; -.
DR CAZy; GT31; Glycosyltransferase Family 31.
DR PaxDb; Q0VC84; -.
DR PRIDE; Q0VC84; -.
DR Ensembl; ENSBTAT00000006572; ENSBTAP00000006571; ENSBTAG00000004995.
DR Ensembl; ENSBTAT00000068688; ENSBTAP00000065467; ENSBTAG00000004995.
DR GeneID; 539417; -.
DR KEGG; bta:539417; -.
DR CTD; 56913; -.
DR VEuPathDB; HostDB:ENSBTAG00000004995; -.
DR VGNC; VGNC:26615; C1GALT1.
DR eggNOG; KOG2246; Eukaryota.
DR GeneTree; ENSGT00940000155000; -.
DR HOGENOM; CLU_035857_0_0_1; -.
DR InParanoid; Q0VC84; -.
DR OMA; PYGIINT; -.
DR OrthoDB; 1407357at2759; -.
DR TreeFam; TF317293; -.
DR Reactome; R-BTA-913709; O-linked glycosylation of mucins.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000009136; Chromosome 4.
DR Bgee; ENSBTAG00000004995; Expressed in abomasum and 108 other tissues.
DR GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB.
DR GO; GO:0016263; F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0001525; P:angiogenesis; ISS:UniProtKB.
DR GO; GO:0060576; P:intestinal epithelial cell development; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; ISS:UniProtKB.
DR GO; GO:0016267; P:O-glycan processing, core 1; IBA:GO_Central.
DR InterPro; IPR026842; C1GALT1.
DR InterPro; IPR003378; Fringe-like.
DR PANTHER; PTHR23033:SF13; PTHR23033:SF13; 1.
DR Pfam; PF02434; Fringe; 1.
PE 2: Evidence at transcript level;
KW Angiogenesis; Developmental protein; Differentiation; Disulfide bond;
KW Glycosyltransferase; Magnesium; Membrane; Metal-binding; Phosphoprotein;
KW Reference proteome; Signal-anchor; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..368
FT /note="Glycoprotein-N-acetylgalactosamine 3-beta-
FT galactosyltransferase 1"
FT /id="PRO_0000285063"
FT TOPO_DOM 1..6
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 7..29
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..368
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT MOD_RES 235
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9JJ06"
SQ SEQUENCE 368 AA; 43041 MW; DF82C20C98CCF250 CRC64;
MASKSWLNIL TFLCGSAVGF VLCSQLLSIL FEEQKDIQPS ILHNDPHARH SDDNEQNHLE
GQMNFDADAS QHKDENTDIA DKLYQKVKIL CWVMTGPQNL EKKAKHVKAT WAQRCNKVLF
MSSEENKDFP AVGLKTREGR DQLYWKTIKA FQYVHDHYLE DADWFMKADD DTYVILDNLR
WLLSKYNPEE PIYFGRRFKP YVKQGYMSGG AGYVLSKEAL KRFVEAFKTD KCTHSSSIED
LALGRCMEII NVEAGDSRDT TGKETFHPFV PEHHLIKGYL PRTFWYWNYN YYPPVEGPGC
CSDLAVSFHY VDPTTMYELE YLVYHLRPYG YLYRYQPALP EKMLKEVSQI YKNEDTNVNQ
EPLKEKHK
