TRPF_METTM
ID TRPF_METTM Reviewed; 226 AA.
AC P26941; D9PUE8;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=N-(5'-phosphoribosyl)anthranilate isomerase;
DE Short=PRAI;
DE EC=5.3.1.24;
GN Name=trpF; OrderedLocusNames=MTBMA_c02370;
OS Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM
OS 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium
OS thermoautotrophicum).
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX NCBI_TaxID=79929;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 /
RC Marburg;
RX PubMed=1860817; DOI=10.1128/jb.173.16.5017-5023.1991;
RA Meile L., Stettler R., Banholzer R., Kotik M., Leisinger T.;
RT "Tryptophan gene cluster of Methanobacterium thermoautotrophicum Marburg:
RT molecular cloning and nucleotide sequence of a putative trpEGCFBAD
RT operon.";
RL J. Bacteriol. 173:5017-5023(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 /
RC Marburg;
RX PubMed=20802048; DOI=10.1128/jb.00844-10;
RA Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H.,
RA Gottschalk G., Thauer R.K.;
RT "Complete genome sequence of Methanothermobacter marburgensis, a
RT methanoarchaeon model organism.";
RL J. Bacteriol. 192:5850-5851(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-
CC carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate;
CC Xref=Rhea:RHEA:21540, ChEBI:CHEBI:18277, ChEBI:CHEBI:58613;
CC EC=5.3.1.24;
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 3/5.
CC -!- SIMILARITY: Belongs to the TrpF family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ADL57846.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M65060; AAA73031.1; -; Genomic_DNA.
DR EMBL; CP001710; ADL57846.1; ALT_INIT; Genomic_DNA.
DR AlphaFoldDB; P26941; -.
DR SMR; P26941; -.
DR STRING; 79929.MTBMA_c02370; -.
DR EnsemblBacteria; ADL57846; ADL57846; MTBMA_c02370.
DR KEGG; mmg:MTBMA_c02370; -.
DR PATRIC; fig|79929.8.peg.233; -.
DR HOGENOM; CLU_076364_2_0_2; -.
DR OMA; DCLDFNS; -.
DR UniPathway; UPA00035; UER00042.
DR Proteomes; UP000000345; Chromosome.
DR GO; GO:0004640; F:phosphoribosylanthranilate isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd00405; PRAI; 1.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00135; PRAI; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR001240; PRAI_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR InterPro; IPR044643; TrpF_fam.
DR PANTHER; PTHR42894; PTHR42894; 1.
DR Pfam; PF00697; PRAI; 1.
DR SUPFAM; SSF51366; SSF51366; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Isomerase;
KW Tryptophan biosynthesis.
FT CHAIN 1..226
FT /note="N-(5'-phosphoribosyl)anthranilate isomerase"
FT /id="PRO_0000154408"
SQ SEQUENCE 226 AA; 24383 MW; CDE5A34BF155E034 CRC64;
MKIKICGLTR EEDVVLADSL GADLLGFIHA RRSPRHLELG DVAELSSLIP DEKAVLVTET
SETSRIMEAI DKTGIERIQL HSVSPETAGK IHESLHAEGY SLELTLAVPP LSSHICGHEF
QGISGLILDS ASGGRTGGTG KIIPPSDALE LLALIRGMDP SLRVTLAGGL TLEFVRKNRE
YVSKFDCLDF NSGIETGPGV KDHEMMAELM NYIEGLPTRK GAIEEI