ID   C1GLT_CHICK             Reviewed;         366 AA.
AC   Q5F3G7;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1;
DE            EC=2.4.1.122 {ECO:0000250|UniProtKB:Q9NS00};
DE   AltName: Full=Core 1 O-glycan T-synthase;
DE   AltName: Full=Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1;
DE   AltName: Full=Core 1 beta1,3-galactosyltransferase 1;
DE            Short=C1GalT1;
DE            Short=Core 1 beta3-Gal-T1;
GN   Name=C1GALT1; ORFNames=RCJMB04_17i7;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Glycosyltransferase that generates the core 1 O-glycan Gal-
CC       beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many
CC       extended O-glycans in glycoproteins. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-
CC         galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-
CC         galactosaminyl derivative + H(+) + UDP; Xref=Rhea:RHEA:15621,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:28257, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:66914, ChEBI:CHEBI:133470; EC=2.4.1.122;
CC         Evidence={ECO:0000250|UniProtKB:Q9NS00};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type II
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 31 family. Beta3-Gal-T
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AJ851683; CAH65317.1; -; mRNA.
DR   RefSeq; NP_001012575.1; NM_001012557.1.
DR   RefSeq; XP_015136885.1; XM_015281399.1.
DR   AlphaFoldDB; Q5F3G7; -.
DR   SMR; Q5F3G7; -.
DR   STRING; 9031.ENSGALP00000015853; -.
DR   CAZy; GT31; Glycosyltransferase Family 31.
DR   PaxDb; Q5F3G7; -.
DR   Ensembl; ENSGALT00000015869; ENSGALP00000015853; ENSGALG00000009752.
DR   GeneID; 420575; -.
DR   KEGG; gga:420575; -.
DR   CTD; 56913; -.
DR   VEuPathDB; HostDB:geneid_420575; -.
DR   eggNOG; KOG2246; Eukaryota.
DR   GeneTree; ENSGT00940000155000; -.
DR   HOGENOM; CLU_035857_0_0_1; -.
DR   InParanoid; Q5F3G7; -.
DR   OrthoDB; 1407357at2759; -.
DR   PhylomeDB; Q5F3G7; -.
DR   TreeFam; TF317293; -.
DR   Reactome; R-GGA-913709; O-linked glycosylation of mucins.
DR   UniPathway; UPA00378; -.
DR   PRO; PR:Q5F3G7; -.
DR   Proteomes; UP000000539; Chromosome 2.
DR   Bgee; ENSGALG00000009752; Expressed in spermatocyte and 14 other tissues.
DR   ExpressionAtlas; Q5F3G7; baseline.
DR   GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB.
DR   GO; GO:0016263; F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0001525; P:angiogenesis; ISS:UniProtKB.
DR   GO; GO:0001822; P:kidney development; ISS:UniProtKB.
DR   GO; GO:0016267; P:O-glycan processing, core 1; IBA:GO_Central.
DR   InterPro; IPR026842; C1GALT1.
DR   InterPro; IPR003378; Fringe-like.
DR   PANTHER; PTHR23033:SF13; PTHR23033:SF13; 1.
DR   Pfam; PF02434; Fringe; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycosyltransferase; Magnesium; Membrane; Metal-binding;
KW   Reference proteome; Signal-anchor; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..366
FT                   /note="Glycoprotein-N-acetylgalactosamine 3-beta-
FT                   galactosyltransferase 1"
FT                   /id="PRO_0000285067"
FT   TOPO_DOM        1..10
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        11..31
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        32..366
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   REGION          341..366
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   366 AA;  42620 MW;  ADA197C8002E4C61 CRC64;
     MASSKSLMNL LTFSFGSAIG FFLCYLLFSM ILEEQVEIQP HILHNDPHGQ HSEDTDNNQL
     QGQMNFNADS GQHRDENRNI ADGLYEKVKI LCWVMTGPQN LEKKARHVKA TWAQRCNKIL
     FMSSEENKDF PTVGLETKEG RDQLYWKTIK AFQYVYDHYF DDADWFMKAD DDTYVILDNL
     RWLLSKYSPE QPIYFGRRFK PYVKQGYMSG GAGYVLSKEA LKRFVTAFKT NKCSHSSSIE
     DLALGKCMEI INVQAGDSRD TSGRETFHPF VPEHLLIRGY LPKTFWYWNY NYYPAVEGPG
     CCSDLAVSFH YVDSMTMYHL EYLVYHLRPY GYSYRYDPDS AKGLEEQNKN EAQEDNPKLK
     QKTSEN