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TRPF_PYRAE
ID   TRPF_PYRAE              Reviewed;         208 AA.
AC   Q8ZV18;
DT   25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=N-(5'-phosphoribosyl)anthranilate isomerase;
DE            Short=PRAI;
DE            EC=5.3.1.24;
GN   Name=trpF; OrderedLocusNames=PAE2499;
OS   Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP
OS   104966 / NBRC 100827 / IM2).
OC   Archaea; Crenarchaeota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC   Pyrobaculum.
OX   NCBI_TaxID=178306;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2;
RX   PubMed=11792869; DOI=10.1073/pnas.241636498;
RA   Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I.,
RA   Miller J.H.;
RT   "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum
RT   aerophilum.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-
CC         carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate;
CC         Xref=Rhea:RHEA:21540, ChEBI:CHEBI:18277, ChEBI:CHEBI:58613;
CC         EC=5.3.1.24;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 3/5.
CC   -!- SIMILARITY: Belongs to the TrpF family. {ECO:0000305}.
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DR   EMBL; AE009441; AAL64238.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8ZV18; -.
DR   SMR; Q8ZV18; -.
DR   STRING; 178306.PAE2499; -.
DR   EnsemblBacteria; AAL64238; AAL64238; PAE2499.
DR   KEGG; pai:PAE2499; -.
DR   PATRIC; fig|178306.9.peg.1863; -.
DR   eggNOG; arCOG01983; Archaea.
DR   HOGENOM; CLU_076364_3_0_2; -.
DR   InParanoid; Q8ZV18; -.
DR   OMA; VKICGVA; -.
DR   UniPathway; UPA00035; UER00042.
DR   Proteomes; UP000002439; Chromosome.
DR   GO; GO:0004640; F:phosphoribosylanthranilate isomerase activity; IBA:GO_Central.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IBA:GO_Central.
DR   CDD; cd00405; PRAI; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00135; PRAI; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001240; PRAI_dom.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   InterPro; IPR044643; TrpF_fam.
DR   PANTHER; PTHR42894; PTHR42894; 1.
DR   Pfam; PF00697; PRAI; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Isomerase;
KW   Reference proteome; Tryptophan biosynthesis.
FT   CHAIN           1..208
FT                   /note="N-(5'-phosphoribosyl)anthranilate isomerase"
FT                   /id="PRO_0000154411"
SQ   SEQUENCE   208 AA;  22396 MW;  418E1F65158B024C CRC64;
     MVLVKICGVV RVEDAVLLDG VADYIGFIVE PTSPRSVKPE ALRSLRDAVI KSRPVLVTAT
     IPPKEAVDIA AKNEIPVVQY HSTLAPKDFD YAETRGVTLA PVAVYKPGIE LKQLVEELLK
     TPHEYVLVDA DKKSQERYEG GLKIPLTLLA EVAPLGRVAL AGGITPENAQ LIARLNPYMI
     DVASGVEASP GVKDMNKVKA LLKAVGRL
 
 
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