TRPF_PYRAE
ID TRPF_PYRAE Reviewed; 208 AA.
AC Q8ZV18;
DT 25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=N-(5'-phosphoribosyl)anthranilate isomerase;
DE Short=PRAI;
DE EC=5.3.1.24;
GN Name=trpF; OrderedLocusNames=PAE2499;
OS Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP
OS 104966 / NBRC 100827 / IM2).
OC Archaea; Crenarchaeota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC Pyrobaculum.
OX NCBI_TaxID=178306;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2;
RX PubMed=11792869; DOI=10.1073/pnas.241636498;
RA Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I.,
RA Miller J.H.;
RT "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum
RT aerophilum.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-
CC carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate;
CC Xref=Rhea:RHEA:21540, ChEBI:CHEBI:18277, ChEBI:CHEBI:58613;
CC EC=5.3.1.24;
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 3/5.
CC -!- SIMILARITY: Belongs to the TrpF family. {ECO:0000305}.
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DR EMBL; AE009441; AAL64238.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8ZV18; -.
DR SMR; Q8ZV18; -.
DR STRING; 178306.PAE2499; -.
DR EnsemblBacteria; AAL64238; AAL64238; PAE2499.
DR KEGG; pai:PAE2499; -.
DR PATRIC; fig|178306.9.peg.1863; -.
DR eggNOG; arCOG01983; Archaea.
DR HOGENOM; CLU_076364_3_0_2; -.
DR InParanoid; Q8ZV18; -.
DR OMA; VKICGVA; -.
DR UniPathway; UPA00035; UER00042.
DR Proteomes; UP000002439; Chromosome.
DR GO; GO:0004640; F:phosphoribosylanthranilate isomerase activity; IBA:GO_Central.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IBA:GO_Central.
DR CDD; cd00405; PRAI; 1.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00135; PRAI; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR001240; PRAI_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR InterPro; IPR044643; TrpF_fam.
DR PANTHER; PTHR42894; PTHR42894; 1.
DR Pfam; PF00697; PRAI; 1.
DR SUPFAM; SSF51366; SSF51366; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Isomerase;
KW Reference proteome; Tryptophan biosynthesis.
FT CHAIN 1..208
FT /note="N-(5'-phosphoribosyl)anthranilate isomerase"
FT /id="PRO_0000154411"
SQ SEQUENCE 208 AA; 22396 MW; 418E1F65158B024C CRC64;
MVLVKICGVV RVEDAVLLDG VADYIGFIVE PTSPRSVKPE ALRSLRDAVI KSRPVLVTAT
IPPKEAVDIA AKNEIPVVQY HSTLAPKDFD YAETRGVTLA PVAVYKPGIE LKQLVEELLK
TPHEYVLVDA DKKSQERYEG GLKIPLTLLA EVAPLGRVAL AGGITPENAQ LIARLNPYMI
DVASGVEASP GVKDMNKVKA LLKAVGRL