ID   TRPF_PYRFU              Reviewed;         208 AA.
AC   Q8U092;
DT   01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=N-(5'-phosphoribosyl)anthranilate isomerase {ECO:0000255|HAMAP-Rule:MF_00135};
DE            Short=PRAI {ECO:0000255|HAMAP-Rule:MF_00135};
DE            EC=5.3.1.24 {ECO:0000255|HAMAP-Rule:MF_00135};
GN   Name=trpF {ECO:0000255|HAMAP-Rule:MF_00135}; OrderedLocusNames=PF1707;
OS   Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=186497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX   PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA   Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA   DiRuggiero J., Robb F.T.;
RT   "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT   horikoshii inferred from complete genomic sequences.";
RL   Genetics 152:1299-1305(1999).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-
CC         carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate;
CC         Xref=Rhea:RHEA:21540, ChEBI:CHEBI:18277, ChEBI:CHEBI:58613;
CC         EC=5.3.1.24; Evidence={ECO:0000255|HAMAP-Rule:MF_00135};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 3/5. {ECO:0000255|HAMAP-
CC       Rule:MF_00135}.
CC   -!- SIMILARITY: Belongs to the TrpF family. {ECO:0000255|HAMAP-
CC       Rule:MF_00135}.
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DR   EMBL; AE009950; AAL81831.1; -; Genomic_DNA.
DR   RefSeq; WP_011012853.1; NZ_CP023154.1.
DR   PDB; 4AAJ; X-ray; 1.75 A; A=1-208.
DR   PDBsum; 4AAJ; -.
DR   AlphaFoldDB; Q8U092; -.
DR   SMR; Q8U092; -.
DR   STRING; 186497.PF1707; -.
DR   EnsemblBacteria; AAL81831; AAL81831; PF1707.
DR   GeneID; 41713538; -.
DR   KEGG; pfu:PF1707; -.
DR   PATRIC; fig|186497.12.peg.1775; -.
DR   eggNOG; arCOG01983; Archaea.
DR   HOGENOM; CLU_076364_2_1_2; -.
DR   OMA; HDHRISQ; -.
DR   OrthoDB; 117266at2157; -.
DR   PhylomeDB; Q8U092; -.
DR   BRENDA; 5.3.1.24; 5243.
DR   UniPathway; UPA00035; UER00042.
DR   Proteomes; UP000001013; Chromosome.
DR   GO; GO:0004640; F:phosphoribosylanthranilate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00405; PRAI; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00135; PRAI; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001240; PRAI_dom.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   InterPro; IPR044643; TrpF_fam.
DR   PANTHER; PTHR42894; PTHR42894; 1.
DR   Pfam; PF00697; PRAI; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Isomerase; Reference proteome; Tryptophan biosynthesis.
FT   CHAIN           1..208
FT                   /note="N-(5'-phosphoribosyl)anthranilate isomerase"
FT                   /id="PRO_0000154412"
FT   STRAND          2..5
FT                   /evidence="ECO:0007829|PDB:4AAJ"
FT   HELIX           11..18
FT                   /evidence="ECO:0007829|PDB:4AAJ"
FT   STRAND          22..27
FT                   /evidence="ECO:0007829|PDB:4AAJ"
FT   STRAND          29..32
FT                   /evidence="ECO:0007829|PDB:4AAJ"
FT   HELIX           38..47
FT                   /evidence="ECO:0007829|PDB:4AAJ"
FT   STRAND          52..56
FT                   /evidence="ECO:0007829|PDB:4AAJ"
FT   HELIX           61..71
FT                   /evidence="ECO:0007829|PDB:4AAJ"
FT   STRAND          74..78
FT                   /evidence="ECO:0007829|PDB:4AAJ"
FT   HELIX           84..94
FT                   /evidence="ECO:0007829|PDB:4AAJ"
FT   STRAND          97..103
FT                   /evidence="ECO:0007829|PDB:4AAJ"
FT   HELIX           111..124
FT                   /evidence="ECO:0007829|PDB:4AAJ"
FT   STRAND          128..133
FT                   /evidence="ECO:0007829|PDB:4AAJ"
FT   HELIX           145..153
FT                   /evidence="ECO:0007829|PDB:4AAJ"
FT   STRAND          156..161
FT                   /evidence="ECO:0007829|PDB:4AAJ"
FT   TURN            164..166
FT                   /evidence="ECO:0007829|PDB:4AAJ"
FT   HELIX           167..174
FT                   /evidence="ECO:0007829|PDB:4AAJ"
FT   STRAND          177..182
FT                   /evidence="ECO:0007829|PDB:4AAJ"
FT   HELIX           183..185
FT                   /evidence="ECO:0007829|PDB:4AAJ"
FT   HELIX           193..205
FT                   /evidence="ECO:0007829|PDB:4AAJ"
SQ   SEQUENCE   208 AA;  22994 MW;  2A00EE4E9FDB7495 CRC64;
     MFVKICGIKS LEELEIVEKH ADATGVVVNS NSKRRIPLEK AREIIENSAI PVFLVSTMVG
     FSEWAMAIER TGAQYIQVHS NALPQTIDTL KKEFGVFVMK AFRVPTISKN PEEDANRLLS
     EISRYNADMV LLDTGAGSGK LHDLRVSSLV ARKIPVIVAG GLNAENVEEV IKVVKPYGVD
     VSSGVEKYGI KDPKLVEEFV RRAKNVVW