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TRPF_SACS2
ID   TRPF_SACS2              Reviewed;         204 AA.
AC   P50386;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=N-(5'-phosphoribosyl)anthranilate isomerase;
DE            Short=PRAI;
DE            EC=5.3.1.24;
GN   Name=trpF; OrderedLocusNames=SSO0892;
OS   Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
OS   (Sulfolobus solfataricus).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Saccharolobus.
OX   NCBI_TaxID=273057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 5833 / MT-4;
RA   Tutino M.L., Cubellis M., Sannia G., Marino G.;
RT   "The tryptophan operon in Sulfolobus solfataricus.";
RL   Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX   PubMed=11427726; DOI=10.1073/pnas.141222098;
RA   She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J.,
RA   Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G.,
RA   Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J.,
RA   Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C.,
RA   Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA   Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT   "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-
CC         carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate;
CC         Xref=Rhea:RHEA:21540, ChEBI:CHEBI:18277, ChEBI:CHEBI:58613;
CC         EC=5.3.1.24;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 3/5.
CC   -!- SIMILARITY: Belongs to the TrpF family. {ECO:0000305}.
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DR   EMBL; Z50014; CAA90310.1; -; Genomic_DNA.
DR   EMBL; AE006641; AAK41174.1; -; Genomic_DNA.
DR   PIR; G90239; G90239.
DR   RefSeq; WP_009992306.1; NC_002754.1.
DR   AlphaFoldDB; P50386; -.
DR   SMR; P50386; -.
DR   STRING; 273057.SSO0892; -.
DR   EnsemblBacteria; AAK41174; AAK41174; SSO0892.
DR   GeneID; 44129822; -.
DR   KEGG; sso:SSO0892; -.
DR   PATRIC; fig|273057.12.peg.895; -.
DR   eggNOG; arCOG01983; Archaea.
DR   HOGENOM; CLU_076364_3_0_2; -.
DR   InParanoid; P50386; -.
DR   OMA; SIMASEM; -.
DR   PhylomeDB; P50386; -.
DR   UniPathway; UPA00035; UER00042.
DR   Proteomes; UP000001974; Chromosome.
DR   GO; GO:0004640; F:phosphoribosylanthranilate isomerase activity; IBA:GO_Central.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IBA:GO_Central.
DR   CDD; cd00405; PRAI; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00135; PRAI; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001240; PRAI_dom.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   InterPro; IPR044643; TrpF_fam.
DR   PANTHER; PTHR42894; PTHR42894; 1.
DR   Pfam; PF00697; PRAI; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Isomerase;
KW   Reference proteome; Tryptophan biosynthesis.
FT   CHAIN           1..204
FT                   /note="N-(5'-phosphoribosyl)anthranilate isomerase"
FT                   /id="PRO_0000154415"
SQ   SEQUENCE   204 AA;  23342 MW;  0697F1FF5D2213BD CRC64;
     MVKLKICGNA TLSDIIEFSK LDVDYLGIIT DVVSQRFVKS EFLTFVKRYV EKPIVNVKVN
     VQISEIEREL LVSDYFQIHR VLDDSELELL KSYDFRKRII LYVPASFEYK KYLERAIDTV
     DMVLVDSVKK GVGVDYNVVS SFLKDYPYLG VGGKISIDNI SNFIDLNPAW LDISSSIEIY
     PGKKDINMVK KIVEVVKYGS SSNK
 
 
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