ID   C1L_VARV                Reviewed;          66 AA.
AC   P0DTP9; P33797;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   29-SEP-2021, entry version 10.
DE   RecName: Full=Truncated interferon antagonist C1L;
GN   ORFNames=C1L;
OS   Variola virus.
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=10255;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bangladesh-1975;
RX   PubMed=8264798; DOI=10.1038/366748a0;
RA   Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C.,
RA   Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A.,
RA   Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.;
RT   "Potential virulence determinants in terminal regions of variola smallpox
RT   virus genome.";
RL   Nature 366:748-751(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Congo-1965, Garcia-1966, and Somalia-1977;
RA   Massung R.F., Loparev V.N., Knight J.C., Chizhikov V.E., Parsons J.M.,
RA   Totmenin A.V., Shchelkunov S.N., Esposito J.J.;
RL   Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- MISCELLANEOUS: This protein is homologous to the N-terminus of
CC       poxviridae interferon antagonist K1L. Presumably a premature stop codon
CC       mutated the gene in variola.
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DR   EMBL; L22579; AAA60769.1; -; Genomic_DNA.
DR   EMBL; U18337; AAA69326.1; -; Genomic_DNA.
DR   EMBL; U18338; AAA69367.1; -; Genomic_DNA.
DR   EMBL; U18340; AAA69432.1; -; Genomic_DNA.
DR   PIR; C72153; C72153.
DR   PIR; T28459; T28459.
DR   RefSeq; NP_042065.1; NC_001611.1.
DR   SMR; P0DTP9; -.
DR   GeneID; 1486576; -.
DR   KEGG; vg:1486576; -.
DR   Proteomes; UP000119805; Genome.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   4: Predicted;
KW   ANK repeat.
FT   CHAIN           1..66
FT                   /note="Truncated interferon antagonist C1L"
FT                   /id="PRO_0000448099"
FT   REPEAT          29..58
FT                   /note="ANK"
SQ   SEQUENCE   66 AA;  7465 MW;  EDCDB1CF8529732B CRC64;
     MDLSRINTRK SKQLKSFLSS KDTFKADVHG HSALYYAIAD NNMRLVCTLL NAGALKNLLE
     NEFPLH