ID   TRPF_ZYGBA              Reviewed;         205 AA.
AC   Q9HFW8;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=N-(5'-phosphoribosyl)anthranilate isomerase;
DE            Short=PRAI;
DE            EC=5.3.1.24;
GN   Name=TRP1;
OS   Zygosaccharomyces bailii.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX   NCBI_TaxID=4954;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CBS 685 / NCYC 563 / NRRL Y-12949;
RX   PubMed=11169759;
RX   DOI=10.1002/1097-0061(20010130)18:2<173::aid-yea663>3.0.co;2-f;
RA   Mollapour M., Piper P.W.;
RT   "Targeted gene deletion in Zygosaccharomyces bailii.";
RL   Yeast 18:173-186(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ISA 1307;
RA   Rodrigues F.J., Steensma Y., Corte-Real M.S.;
RT   "Sequence analyses of a Zygosaccharomyces bailii DNA fragment containing
RT   the Thr-tRNA, IPP1 and TRP1 genes.";
RL   Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-
CC         carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate;
CC         Xref=Rhea:RHEA:21540, ChEBI:CHEBI:18277, ChEBI:CHEBI:58613;
CC         EC=5.3.1.24;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 3/5.
CC   -!- SIMILARITY: Belongs to the TrpF family. {ECO:0000305}.
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DR   EMBL; AF279262; AAG17697.1; -; Genomic_DNA.
DR   EMBL; AJ309279; CAC37331.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9HFW8; -.
DR   SMR; Q9HFW8; -.
DR   UniPathway; UPA00035; UER00042.
DR   GO; GO:0004640; F:phosphoribosylanthranilate isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00405; PRAI; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00135; PRAI; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001240; PRAI_dom.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   InterPro; IPR044643; TrpF_fam.
DR   PANTHER; PTHR42894; PTHR42894; 1.
DR   Pfam; PF00697; PRAI; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Isomerase;
KW   Tryptophan biosynthesis.
FT   CHAIN           1..205
FT                   /note="N-(5'-phosphoribosyl)anthranilate isomerase"
FT                   /id="PRO_0000154338"
SQ   SEQUENCE   205 AA;  22316 MW;  DECD9AE9F0DDBC0E CRC64;
     MIAKICGLQS VEAAQQAVDN GADLIGVICV PNRKRTVDPE IARSISKICH GTGTRLVGVF
     RNQPKEEVRQ LAQEYELDVV QLHGDEDWQE YASYVGLPLL KRVVFPRDVS LVSQMDGEVC
     TPLFDSEAGG SGEKLDWQAI GSWFQDSQLT RGYLLAGGLS PDNVVEALRV PGVVGVDVSG
     GVETDGTKDL AKIKQFLELY KVNVN