TRPG_CAEEL
ID TRPG_CAEEL Reviewed; 2032 AA.
AC Q93971; P91909;
DT 19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 4.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Transient receptor potential channel;
DE AltName: Full=Abnormal gonad development protein 2;
GN Name=gon-2; ORFNames=T01H8.5/T01H8.3/T01H8.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|EMBL:CAB02303.2};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND MUTANTS.
RX PubMed=11290424; DOI=10.1016/s0378-1119(01)00373-0;
RA West R.J., Sun A.Y., Church D.L., Lambie E.J.;
RT "The C. elegans gon-2 gene encodes a putative TRP cation channel protein
RT required for mitotic cell cycle progression.";
RL Gene 266:103-110(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3] {ECO:0000305}
RP FUNCTION, AND MUTAGENESIS OF GLY-427; SER-603; CYS-656; GLU-955 AND
RP SER-1566.
RC STRAIN=Bristol N2;
RX PubMed=9383054; DOI=10.1093/genetics/147.3.1077;
RA Sun A.Y., Lambie E.J.;
RT "gon-2, a gene required for gonadogenesis in Caenorhabditis elegans.";
RL Genetics 147:1077-1089(1997).
CC -!- FUNCTION: Required for initiation and continuation of postembryonic
CC mitotic cell divisions of gonadal cells Z1 and Z4. Zygotic expression
CC is necessary for hermaphrodite fertility. May be a cation channel.
CC {ECO:0000269|PubMed:11290424, ECO:0000269|PubMed:9383054,
CC ECO:0000303|PubMed:11290424}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Gonads. {ECO:0000269|PubMed:9383054}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically during
CC embryonic development. Zygotic expression starts during early embryonic
CC cleavage. {ECO:0000269|PubMed:9383054}.
CC -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. LTrpC
CC subfamily. {ECO:0000305}.
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DR EMBL; Z80219; CAB02303.2; -; Genomic_DNA.
DR EMBL; Z83117; CAB02303.2; JOINED; Genomic_DNA.
DR PIR; T23707; T23707.
DR RefSeq; NP_492315.4; NM_059914.5.
DR AlphaFoldDB; Q93971; -.
DR SMR; Q93971; -.
DR BioGRID; 38079; 1.
DR IntAct; Q93971; 2.
DR STRING; 6239.T01H8.5a; -.
DR TCDB; 1.A.4.5.10; the transient receptor potential ca(2+) channel (trp-cc) family.
DR iPTMnet; Q93971; -.
DR PaxDb; Q93971; -.
DR EnsemblMetazoa; T01H8.5a.1; T01H8.5a.1; WBGene00001651.
DR GeneID; 172646; -.
DR KEGG; cel:CELE_T01H8.5; -.
DR UCSC; T01H8.5a; c. elegans.
DR CTD; 172646; -.
DR WormBase; T01H8.5a; CE30390; WBGene00001651; gon-2.
DR eggNOG; KOG3614; Eukaryota.
DR GeneTree; ENSGT00940000168570; -.
DR InParanoid; Q93971; -.
DR OMA; EAQADCE; -.
DR OrthoDB; 738147at2759; -.
DR PhylomeDB; Q93971; -.
DR Reactome; R-CEL-3295583; TRP channels.
DR PRO; PR:Q93971; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00001651; Expressed in embryo and 4 other tissues.
DR ExpressionAtlas; Q93971; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISS:WormBase.
DR GO; GO:0005261; F:cation channel activity; IBA:GO_Central.
DR GO; GO:0008324; F:cation transmembrane transporter activity; ISS:WormBase.
DR GO; GO:0098655; P:cation transmembrane transport; IBA:GO_Central.
DR GO; GO:0006812; P:cation transport; ISS:WormBase.
DR GO; GO:0030421; P:defecation; IMP:WormBase.
DR GO; GO:0008406; P:gonad development; IMP:UniProtKB.
DR GO; GO:0000278; P:mitotic cell cycle; IMP:UniProtKB.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
PE 1: Evidence at protein level;
KW Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..2032
FT /note="Transient receptor potential channel"
FT /id="PRO_0000215361"
FT TRANSMEM 1310..1330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1332..1352
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1374..1394
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1439..1459
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1535..1555
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 129..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 831..860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 912..945
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1120..1211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1753..1779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1853..1909
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1935..1982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1999..2032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 837..859
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1120..1148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1155..1170
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1171..1185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1853..1874
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2011..2032
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 427
FT /note="G->R: In allele gon-2(dx22); gonadless phenotype."
FT /evidence="ECO:0000269|PubMed:9383054"
FT MUTAGEN 603
FT /note="S->N: In allele gon-2(dx58); gonadless phenotype."
FT /evidence="ECO:0000269|PubMed:9383054"
FT MUTAGEN 656
FT /note="C->Y: In allele gon-2(q362); gonadless phenotype."
FT /evidence="ECO:0000269|PubMed:9383054"
FT MUTAGEN 955
FT /note="E->K: In allele gon-2(q388); gonadless phenotype."
FT /evidence="ECO:0000269|PubMed:9383054"
FT MUTAGEN 1566
FT /note="S->F: In allele gon-2(dx87); gonadless phenotype."
FT /evidence="ECO:0000269|PubMed:9383054"
SQ SEQUENCE 2032 AA; 229063 MW; 07B559E7E844DB05 CRC64;
MMSDDMLDEN DENFACQDVD EIIIYVPEFA GYREVNIDTA VSVCPTPIQQ ARRESSCRNL
EMRRRFEKLR REKKEEKKLL ADDEKDFDED DDVFEDGEGL QMRTFQPNAS IRDENGSMPS
LLPRTAPIKK TRKHRRRRSG SFTGGVYPRK GHRNRSLLGH AIPPPNVHSA DWRDMLAITD
NKDDKLMKTL GVTRYLQSKG GDQVPPTSTT TGGAGGDGNA VPTTSQAQAQ TFNSGRQTTG
MSSGDRLNED VSATANSAQL VLPTPLFNQM RFTESNMSLN RHNWVRETFT RRECSRFIAS
SRDLHKCGCG RTRDAHRNIP ELTSEFLRQK RSVAALEQQR SISNVNDDIN TQNMYTKRGA
NEKWSLRKHT VSLATNAFGQ VEFQGGPHPY KAQYVRVNFD TEPAYIMSLF EHVWQISPPR
LIITVHGGTS NFDLQPKLAR VFRKGLLKAA STTGAWIITS GCDTGVVKHV AAALEGAQSA
QRNKIVCIGI APWGLLKKRE DFIGQDKTVP YYPSSSKGRF TGLNNRHSYF LLVDNGTVGR
YGAEVILRKR LEMYISQKQK IFGGTRSVPV VCVVLEGGSC TIRSVLDYVT NVPRVPVVVC
DGSGRAADLL AFAHQNVTED GLLPDDIRRQ VLLLVETTFG CSEAAAHRLL HELTVCAQHK
NLLTIFRLGE QGEHDVDHAI LTALLKGQNL SAADQLALAL AWNRVDIARS DVFAMGHEWP
QAALHNAMME ALIHDRVDFV RLLLEQGINM QKFLTISRLD ELYNTDKGPP NTLFYIVRDV
VRVRQGYRFK LPDIGLVIEK LMGNSYQCSY TTSEFRDKYK QRMKRVKHAQ KKAMGVFSSR
PSRTGSGIAS RQSTEGMGGV GGGSSVAGVF GNSFGNQDPP LDPHVNRSAL SGSRALSNHI
LWRSAFRGNF PANPMRPPNL GDSRDCGSEF DEELSLTSAS DGSQTEPDFR YPYSELMIWA
VLTKRQDMAM CMWQHGEEAM AKALVACRLY KSLATEAAED YLEVEICEEL KKYAEEFRIL
SLELLDHCYH VDDAQTLQLL TYELSNWSNE TCLALAVIVN NKHFLAHPCC QILLADLWHG
GLRMRTHSNI KVVLGLICPP FIQMLEFKTR EELLNQPQTA AEHQNDMNYS SSSSSSSSSS
SSSSSSDSSS FEDDDDENNA HNHDQKRTRK TSQGSAQSLN ITSLFHSRRR KAKKNEKCDR
ETDASACEAG NRQIQNGGLT AEYGTFGESN GVSPPPPYMR ANSRSRYNNR SDMSKTSSVI
FGSDPNLSKL QKSNITSTDR PNPMEQFQGT RKIKMRRRFY EFYSAPISTF WSWTISFILF
ITFFTYTLLV KTPPRPTVIE YILIAYVAAF GLEQVRKIIM SDAKPFYEKI RTYVCSFWNC
VTILAIIFYI VGFFMRCFGS VAYGRVILAC DSVLWTMKLL DYMSVHPKLG PYVTMAGKMI
QNMSYIIVML VVTLLSFGLA RQSITYPDET WHWILVRNIF LKPYFMLYGE VYADEIDTCG
DEAWDQHLEN GGPVILGNGT TGLSCVPGYW IPPLLMTFFL LIANILLMSM LIAIFNHIFD
ATDEMSQQIW LFQRYKQVME YESTPFLPPP LTPLYHGVLI LQFVRTRLSC SKSQERNPMF
DFSLKLFLDN DQIEKLHDFE EDCMEDLARQ KLNEKNTSNE QRILRADIRT DQILNRLIDL
QAKESMGRDV INDVESRLAS VEKAQNEILE CVRALLNQNN APTAIGRCFS PSPDPLVETA
NGTPGPLLLK LPGTDPILEE KDHDSGENSN SLPPGRIRRN RTATICGGYV SEERNMMLLS
PKPSDVSGIP QQRLMSVTSM DPLPLPLAKL STMSIRRRHE EYTSITDSIA IRHPERRIRN
NRSNSSEHDE SAVDSEGGGN VTSSPRKRST RDLRMTPSSQ VEESTSRDQI FEIDHPEHEE
DEAQADCELT DVITEEEDEE EDDEEDDSHE RHHIHPRRKS SRQNRQPSHT LETDLSEGEE
VDPLDVLKMK ELPIIHQILN EEEQAGAPHS TPVIASPSSS RADLTSQKCS DV
