TRPG_DROME
ID TRPG_DROME Reviewed; 1128 AA.
AC Q9VJJ7; A4V0S8; Q9N6L1;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 174.
DE RecName: Full=Transient receptor potential-gamma protein;
DE Short=TRPgamma;
DE AltName: Full=Transient receptor potential cation channel gamma;
GN Name=Trpgamma; ORFNames=CG5996;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TRP AND TRPL, AND
RP TISSUE SPECIFICITY.
RC TISSUE=Head;
RX PubMed=10896160; DOI=10.1016/s0896-6273(00)81201-5;
RA Xu X.-Z.S., Chien F., Butler A., Salkoff L., Montell C.;
RT "TRPgamma, a Drosophila TRP-related subunit, forms a regulated cation
RT channel with TRPL.";
RL Neuron 26:647-657(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- FUNCTION: A light-sensitive calcium channel that is required for
CC inositide-mediated Ca(2+) entry in the retina during phospholipase C
CC (PLC)-mediated phototransduction (By similarity). Forms a regulated
CC cation channel when heteromultimerized with trpl. {ECO:0000250,
CC ECO:0000269|PubMed:10896160}.
CC -!- SUBUNIT: Interacts preferentially with trpl and interacts to a lower
CC extent with trp. {ECO:0000269|PubMed:10896160}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in the rhabdomeres of
CC photoreceptor cells. {ECO:0000269|PubMed:10896160}.
CC -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. STrpC
CC subfamily. {ECO:0000305}.
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DR EMBL; AJ277967; CAB96204.1; -; mRNA.
DR EMBL; AJ277968; CAB96205.1; -; mRNA.
DR EMBL; AE014134; AAF53548.2; -; Genomic_DNA.
DR EMBL; AE014134; AAN10950.1; -; Genomic_DNA.
DR RefSeq; NP_609802.1; NM_135958.5.
DR RefSeq; NP_723983.1; NM_165169.5.
DR AlphaFoldDB; Q9VJJ7; -.
DR SMR; Q9VJJ7; -.
DR BioGRID; 60999; 1.
DR IntAct; Q9VJJ7; 2.
DR STRING; 7227.FBpp0080498; -.
DR TCDB; 1.A.4.1.15; the transient receptor potential ca(2+) channel (trp-cc) family.
DR PaxDb; Q9VJJ7; -.
DR PRIDE; Q9VJJ7; -.
DR EnsemblMetazoa; FBtr0080945; FBpp0080498; FBgn0032593.
DR EnsemblMetazoa; FBtr0080946; FBpp0080499; FBgn0032593.
DR GeneID; 34991; -.
DR KEGG; dme:Dmel_CG5996; -.
DR UCSC; CG5996-RA; d. melanogaster.
DR CTD; 34991; -.
DR FlyBase; FBgn0032593; Trpgamma.
DR VEuPathDB; VectorBase:FBgn0032593; -.
DR eggNOG; KOG3609; Eukaryota.
DR GeneTree; ENSGT01050000244985; -.
DR HOGENOM; CLU_005716_3_1_1; -.
DR InParanoid; Q9VJJ7; -.
DR OMA; QSPDEKC; -.
DR PhylomeDB; Q9VJJ7; -.
DR Reactome; R-DME-3295583; TRP channels.
DR Reactome; R-DME-5578775; Ion homeostasis.
DR Reactome; R-DME-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
DR BioGRID-ORCS; 34991; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 34991; -.
DR PRO; PR:Q9VJJ7; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0032593; Expressed in crop (Drosophila) and 2 other tissues.
DR ExpressionAtlas; Q9VJJ7; baseline and differential.
DR Genevisible; Q9VJJ7; DM.
DR GO; GO:0034703; C:cation channel complex; IPI:FlyBase.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043025; C:neuronal cell body; IDA:FlyBase.
DR GO; GO:1990635; C:proximal dendrite; IDA:FlyBase.
DR GO; GO:0016028; C:rhabdomere; IDA:UniProtKB.
DR GO; GO:0005262; F:calcium channel activity; ISS:UniProtKB.
DR GO; GO:0005261; F:cation channel activity; IDA:FlyBase.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IBA:GO_Central.
DR GO; GO:0008381; F:mechanosensitive ion channel activity; IDA:FlyBase.
DR GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR GO; GO:0007628; P:adult walking behavior; IMP:FlyBase.
DR GO; GO:0070588; P:calcium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006816; P:calcium ion transport; ISS:UniProtKB.
DR GO; GO:0006812; P:cation transport; IDA:FlyBase.
DR GO; GO:0050908; P:detection of light stimulus involved in visual perception; ISS:UniProtKB.
DR GO; GO:0006828; P:manganese ion transport; IBA:GO_Central.
DR GO; GO:0050884; P:neuromuscular process controlling posture; IMP:FlyBase.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR GO; GO:0009416; P:response to light stimulus; ISS:UniProtKB.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR002153; TRPC_channel.
DR PANTHER; PTHR10117; PTHR10117; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 1: Evidence at protein level;
KW ANK repeat; Calcium; Calcium channel; Calcium transport; Ion channel;
KW Ion transport; Membrane; Reference proteome; Repeat; Sensory transduction;
KW Transmembrane; Transmembrane helix; Transport; Vision.
FT CHAIN 1..1128
FT /note="Transient receptor potential-gamma protein"
FT /id="PRO_0000215358"
FT TOPO_DOM 1..325
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 347..403
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 404..424
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 425..444
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 445..465
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 466..492
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 493..513
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 514..535
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 536..556
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 557..629
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 630..650
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 651..1128
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 57..86
FT /note="ANK 1"
FT REPEAT 131..160
FT /note="ANK 2"
FT REGION 865..898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1064..1111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1089..1111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 195
FT /note="S -> G (in Ref. 1; CAB96204/CAB96205)"
FT /evidence="ECO:0000305"
FT CONFLICT 222
FT /note="F -> L (in Ref. 1; CAB96204/CAB96205)"
FT /evidence="ECO:0000305"
FT CONFLICT 1053
FT /note="D -> N (in Ref. 1; CAB96204/CAB96205)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1128 AA; 127109 MW; A0B519C7DFBE5983 CRC64;
MMEEENTIRP HQEIRQLTLE EKKFLLAVER GDMAGTRRML QKAQDTEYIN VNCVDPLGRT
ALLMAIDNEN LEMVELLINY NVDTKDALLH SISEEFVEAV EVLLDHENVT FHSEGNHSWE
SASEDTSTFT PDITPLILAA HRDNYEIIKI LLDRGAVLPM PHDVRCGCDE CVQSRQEDSL
RHSRSRINAY RALASPSLIA LSSKDPILTA FELSWELRRL SFLEHEFKNE YQELRKQCQD
FATALLDHTR TSHELEILLN HDPTGPVYEH GERMHLNRLK LAIKLRQKKF VAHSNVQQLL
ASIWYEGLPG FRRKNMALQA VDIIRIGIMF PIFSLAYILA PYSSIGQTMR KPFIKFICHS
ASYFTFLFLL MLASQRIETF IGGWFFADSS GMLNTMEELP TKRGAKPTFI EWLILAWVSG
LIWSEVKQLW DVGLQEYLND MWNVIDFVTN SLYVATVALR VVSFFQVQKE MIYNSHATDL
PRERWDAWDP MLISEGLFSA ANIFSSLKLV YIFSVNPHLG PLQVSLSRMV MDIMKFFFLY
VLVLFAFGSG LNQLLWYYAD LEKKRCPEVS PMSALLNMNG TNDPNACIVW RRFSNLFETT
QTLFWAVFGL IDLDSFELDG IKIFTRFWGM LMFGTYSVIN IVVLLNLLIA MMNHSYQLIS
ERADVEWKFA RSKLWISYFE EGGTCPPPFN IIPTPKSIWY AIKWMRRVFC SGSSAARREH
LKTIRRKAQQ ASDRDFKYQQ IMRNLVRRYV TVEQRKAESQ GVTEDDVNEI KQDISAFRCE
LVEILKNSGM DTNVTAGQGG GGGGKKNRQK ERRLMKGFNI APPGSTGSLA PVAEFSTSLD
NYDNQHEILS STLSTLFTPN FMHKRQQSQA GSGGGGSESP TTPTAPQGTQ GAAMTASSQV
TKYNKSALKP YNKRIAGHKK RWGTLIEAAK VGNVSKMLGR SKSEDSVCNS SHTSTPVHGQ
MRVTYAQNSP QQEYGYHGET SSTTISTPTP TISVVSNSPA AHAGVGSHFF HTTSGLTAIA
ALKRKRKKFS SSKNICPVTE SVAAANAAEI LNDKTLKRVS SYPAAEAGVQ HNPAQLVKPR
RHEQTQSQHD SVETNSTFTL SIDPSNTSVN SREPLISTSC VSTTGAIG
