ID   TRPI_PSESY              Reviewed;         298 AA.
AC   P34818;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=HTH-type transcriptional regulator TrpI;
DE   AltName: Full=TrpBA operon transcriptional activator;
GN   Name=trpI;
OS   Pseudomonas syringae pv. syringae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas; Pseudomonas syringae.
OX   NCBI_TaxID=321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=8423001; DOI=10.1016/0378-1119(93)90534-a;
RA   Auerbach S., Gao J., Gussin G.N.;
RT   "Nucleotide sequences of the trpI, trpB, and trpA genes of Pseudomonas
RT   syringae: positive control unique to fluorescent pseudomonads.";
RL   Gene 123:25-32(1993).
CC   -!- FUNCTION: Activates the expression of the trpBA genes, which encode the
CC       two tryptophan synthase subunits, and represses initiation at its own
CC       promoter. {ECO:0000269|PubMed:8423001}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; M95710; AAA26015.1; -; Genomic_DNA.
DR   PIR; JQ2125; JQ2125.
DR   AlphaFoldDB; P34818; -.
DR   SMR; P34818; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd08482; PBP2_TrpI; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR037418; TrpI_PBP2.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   DNA-binding; Repressor; Transcription; Transcription regulation;
KW   Tryptophan biosynthesis.
FT   CHAIN           1..298
FT                   /note="HTH-type transcriptional regulator TrpI"
FT                   /id="PRO_0000105765"
FT   DOMAIN          6..63
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        23..42
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   298 AA;  32416 MW;  52D65FC34C15996B CRC64;
     MSRDLPPLNA LRAFEATARL NSVSQAAEQL HVTHGAVSRQ LKVLEEHLGI SLFVKDGRGL
     KLTDAGARLR DASAEAFERL RDVCAELTQS SADAPFVLGC SGSLLARWLI PRLGRLNADL
     PDLRLHLSAG DGDLDPRRPG LDALLVFAEP PWPADMQVYE LTSERIGPVM SPRFAGYERL
     SHAPAAALCG EALLHTTSRP QAWPSWAQQH GIEPGALKHG QGFEHLYYLL EAAVAGLGVA
     IAPEPLVAED LRAGRLVAPW GFSETPAHLA LWLPNARRDG RAGQLAQWLK AELLRQPY