ID   TRPP_BACSU              Reviewed;         172 AA.
AC   O07515;
DT   31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 2.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Probable tryptophan transport protein;
GN   Name=trpP; OrderedLocusNames=BSU10010;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9579061; DOI=10.1099/00221287-144-4-859;
RA   Noback M.A., Holsappel S., Kiewiet R., Terpstra P., Wambutt R., Wedler H.,
RA   Venema G., Bron S.;
RT   "The 172 kb prkA-addAB region from 83 degrees to 97 degrees of the Bacillus
RT   subtilis chromosome contains several dysfunctional genes, the glyB marker,
RT   many genes encoding transporter proteins, and the ubiquitous hit gene.";
RL   Microbiology 144:859-875(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   SEQUENCE REVISION TO 31 AND 130-132.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
RN   [4]
RP   PUTATIVE FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=10735881; DOI=10.1128/jb.182.8.2329-2331.2000;
RA   Sarsero J.P., Merino E., Yanofsky C.;
RT   "A Bacillus subtilis gene of previously unknown function, yhaG, is
RT   translationally regulated by tryptophan-activated TRAP and appears to be
RT   involved in tryptophan transport.";
RL   J. Bacteriol. 182:2329-2331(2000).
CC   -!- FUNCTION: Probably involved in tryptophan uptake.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Its translation is regulated by tryptophan-activated RNA-
CC       binding regulatory protein (TRAP). {ECO:0000269|PubMed:10735881}.
CC   -!- DISRUPTION PHENOTYPE: Cells lacking this gene grow on 40-fold higher
CC       concentrations of the tryptophan analog 5-fluorotryptophan than the
CC       level that inhibits the wild-type strain.
CC       {ECO:0000269|PubMed:10735881}.
CC   -!- SIMILARITY: Belongs to the vitamin uptake transporter (VUT/ECF) (TC
CC       2.A.88) family. TrpP subfamily. {ECO:0000305}.
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DR   EMBL; Y14077; CAA74412.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12841.2; -; Genomic_DNA.
DR   PIR; A69818; A69818.
DR   RefSeq; NP_388882.2; NC_000964.3.
DR   RefSeq; WP_003233236.1; NZ_JNCM01000035.1.
DR   AlphaFoldDB; O07515; -.
DR   SMR; O07515; -.
DR   STRING; 224308.BSU10010; -.
DR   TCDB; 2.A.88.4.1; the vitamin uptake transporter (vut) family.
DR   PaxDb; O07515; -.
DR   PRIDE; O07515; -.
DR   EnsemblBacteria; CAB12841; CAB12841; BSU_10010.
DR   GeneID; 936290; -.
DR   KEGG; bsu:BSU10010; -.
DR   PATRIC; fig|224308.179.peg.1077; -.
DR   eggNOG; ENOG5032SBU; Bacteria.
DR   InParanoid; O07515; -.
DR   OMA; DMMLTMM; -.
DR   PhylomeDB; O07515; -.
DR   BioCyc; BSUB:BSU10010-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR031360; TrpP.
DR   Pfam; PF17099; TrpP; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid transport; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..172
FT                   /note="Probable tryptophan transport protein"
FT                   /id="PRO_0000109850"
FT   TRANSMEM        7..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        31
FT                   /note="K -> Q (in Ref. 1; CAA74412)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        130..132
FT                   /note="GGF -> AVI (in Ref. 1; CAA74412)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   172 AA;  18250 MW;  76F063702CA808CC CRC64;
     MKTKELVIMA LFAAIGAALH SIIPPFLGGM KPDMMLIMMF MGILLFPRVQ NVLVIGIVTG
     IISALTTAFP AGQIPNIIDK PVSAFLFFSL FLLFRKSRKT GAAAVLTVIG TILSGIVFLS
     SALLIVGLPG GFAALFAAVV LPAAVLNTIS MIIIYPIVQT ILRRSSFMEA AK