TRPR_CHLTB
ID TRPR_CHLTB Reviewed; 94 AA.
AC B0BBF0;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Trp operon repressor homolog {ECO:0000255|HAMAP-Rule:MF_00475};
GN Name=trpR {ECO:0000255|HAMAP-Rule:MF_00475}; OrderedLocusNames=CTLon_0416;
OS Chlamydia trachomatis serovar L2b (strain UCH-1/proctitis).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=471473;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UCH-1/proctitis;
RX PubMed=18032721; DOI=10.1101/gr.7020108;
RA Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P.,
RA Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D.,
RA Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N.;
RT "Chlamydia trachomatis: genome sequence analysis of lymphogranuloma
RT venereum isolates.";
RL Genome Res. 18:161-171(2008).
CC -!- FUNCTION: This protein is an aporepressor. When complexed with L-
CC tryptophan it binds the operator region of the trp operon and prevents
CC the initiation of transcription. {ECO:0000255|HAMAP-Rule:MF_00475}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00475}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00475}.
CC -!- SIMILARITY: Belongs to the TrpR family. {ECO:0000255|HAMAP-
CC Rule:MF_00475}.
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DR EMBL; AM884177; CAP06814.1; -; Genomic_DNA.
DR RefSeq; WP_009873611.1; NC_010280.2.
DR AlphaFoldDB; B0BBF0; -.
DR SMR; B0BBF0; -.
DR KEGG; ctl:CTLon_0416; -.
DR HOGENOM; CLU_147939_0_2_0; -.
DR OMA; GQMSQRE; -.
DR Proteomes; UP000000794; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1270.10; -; 1.
DR HAMAP; MF_00475; Trp_repressor; 1.
DR InterPro; IPR000831; Trp_repress.
DR InterPro; IPR013335; Trp_repress_bac.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR InterPro; IPR038116; TrpR-like_sf.
DR PANTHER; PTHR38025; PTHR38025; 1.
DR Pfam; PF01371; Trp_repressor; 1.
DR PIRSF; PIRSF003196; Trp_repressor; 1.
DR SUPFAM; SSF48295; SSF48295; 1.
DR TIGRFAMs; TIGR01321; TrpR; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..94
FT /note="Trp operon repressor homolog"
FT /id="PRO_1000197140"
FT DNA_BIND 58..81
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00475"
SQ SEQUENCE 94 AA; 10875 MW; 151D0D42B12A9D06 CRC64;
MKNQEESGWQ AFLTLCSKMQ KEKFLQDLFS LFLSFGERKD VASRYHIIRA LLEGELTQRE
IAEKYGVSIA QITRGSNALK GSDPQFKEFL QKEI