TRPR_CHLTR
ID TRPR_CHLTR Reviewed; 94 AA.
AC O84171;
DT 02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=Trp operon repressor homolog;
GN Name=trpR; OrderedLocusNames=CT_169;
OS Chlamydia trachomatis (strain D/UW-3/Cx).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=272561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D/UW-3/Cx;
RX PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.;
RT "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia
RT trachomatis.";
RL Science 282:754-759(1998).
CC -!- FUNCTION: This protein is an aporepressor. When complexed with L-
CC tryptophan it binds the operator region of the trp operon and prevents
CC the initiation of transcription (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TrpR family. {ECO:0000305}.
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DR EMBL; AE001273; AAC67760.1; -; Genomic_DNA.
DR PIR; H71549; H71549.
DR RefSeq; NP_219672.1; NC_000117.1.
DR RefSeq; WP_009871513.1; NC_000117.1.
DR AlphaFoldDB; O84171; -.
DR SMR; O84171; -.
DR STRING; 813.O172_00900; -.
DR EnsemblBacteria; AAC67760; AAC67760; CT_169.
DR GeneID; 884964; -.
DR KEGG; ctr:CT_169; -.
DR PATRIC; fig|272561.5.peg.182; -.
DR HOGENOM; CLU_147939_0_2_0; -.
DR InParanoid; O84171; -.
DR OMA; GQMSQRE; -.
DR Proteomes; UP000000431; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.1270.10; -; 1.
DR HAMAP; MF_00475; Trp_repressor; 1.
DR InterPro; IPR000831; Trp_repress.
DR InterPro; IPR013335; Trp_repress_bac.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR InterPro; IPR038116; TrpR-like_sf.
DR PANTHER; PTHR38025; PTHR38025; 1.
DR Pfam; PF01371; Trp_repressor; 1.
DR PIRSF; PIRSF003196; Trp_repressor; 1.
DR SUPFAM; SSF48295; SSF48295; 1.
DR TIGRFAMs; TIGR01321; TrpR; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..94
FT /note="Trp operon repressor homolog"
FT /id="PRO_0000196508"
FT DNA_BIND 58..81
FT /evidence="ECO:0000250"
SQ SEQUENCE 94 AA; 10932 MW; 151D1956A99D8906 CRC64;
MKNQEESGWQ AFLTLCSKMQ KEKFLQDLFS LFLSFSERKD VASRYHIIRA LLEGELTQRE
IAEKYGVSIA QITRGSNALK GLDPQFKEFL QKEI