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TRPR_CHLTR
ID   TRPR_CHLTR              Reviewed;          94 AA.
AC   O84171;
DT   02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=Trp operon repressor homolog;
GN   Name=trpR; OrderedLocusNames=CT_169;
OS   Chlamydia trachomatis (strain D/UW-3/Cx).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=272561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D/UW-3/Cx;
RX   PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA   Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA   Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.;
RT   "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia
RT   trachomatis.";
RL   Science 282:754-759(1998).
CC   -!- FUNCTION: This protein is an aporepressor. When complexed with L-
CC       tryptophan it binds the operator region of the trp operon and prevents
CC       the initiation of transcription (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TrpR family. {ECO:0000305}.
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DR   EMBL; AE001273; AAC67760.1; -; Genomic_DNA.
DR   PIR; H71549; H71549.
DR   RefSeq; NP_219672.1; NC_000117.1.
DR   RefSeq; WP_009871513.1; NC_000117.1.
DR   AlphaFoldDB; O84171; -.
DR   SMR; O84171; -.
DR   STRING; 813.O172_00900; -.
DR   EnsemblBacteria; AAC67760; AAC67760; CT_169.
DR   GeneID; 884964; -.
DR   KEGG; ctr:CT_169; -.
DR   PATRIC; fig|272561.5.peg.182; -.
DR   HOGENOM; CLU_147939_0_2_0; -.
DR   InParanoid; O84171; -.
DR   OMA; GQMSQRE; -.
DR   Proteomes; UP000000431; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.1270.10; -; 1.
DR   HAMAP; MF_00475; Trp_repressor; 1.
DR   InterPro; IPR000831; Trp_repress.
DR   InterPro; IPR013335; Trp_repress_bac.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   InterPro; IPR038116; TrpR-like_sf.
DR   PANTHER; PTHR38025; PTHR38025; 1.
DR   Pfam; PF01371; Trp_repressor; 1.
DR   PIRSF; PIRSF003196; Trp_repressor; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   TIGRFAMs; TIGR01321; TrpR; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..94
FT                   /note="Trp operon repressor homolog"
FT                   /id="PRO_0000196508"
FT   DNA_BIND        58..81
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   94 AA;  10932 MW;  151D1956A99D8906 CRC64;
     MKNQEESGWQ AFLTLCSKMQ KEKFLQDLFS LFLSFSERKD VASRYHIIRA LLEGELTQRE
     IAEKYGVSIA QITRGSNALK GLDPQFKEFL QKEI
 
 
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