TRPR_ECOK1
ID TRPR_ECOK1 Reviewed; 108 AA.
AC A1AJW2;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Trp operon repressor {ECO:0000255|HAMAP-Rule:MF_00475};
GN Name=trpR {ECO:0000255|HAMAP-Rule:MF_00475}; OrderedLocusNames=Ecok1_44580;
GN ORFNames=APECO1_1986;
OS Escherichia coli O1:K1 / APEC.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=405955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17293413; DOI=10.1128/jb.01726-06;
RA Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J.,
RA Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.;
RT "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7
RT shares strong similarities with human extraintestinal pathogenic E. coli
RT genomes.";
RL J. Bacteriol. 189:3228-3236(2007).
CC -!- FUNCTION: This protein is an aporepressor. When complexed with L-
CC tryptophan it binds the operator region of the trp operon (5'-
CC ACTAGT-'3') and prevents the initiation of transcription. The complex
CC also regulates trp repressor biosynthesis by binding to its regulatory
CC region. {ECO:0000255|HAMAP-Rule:MF_00475}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00475}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00475}.
CC -!- SIMILARITY: Belongs to the TrpR family. {ECO:0000255|HAMAP-
CC Rule:MF_00475}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000468; ABJ03952.1; -; Genomic_DNA.
DR RefSeq; WP_000068677.1; NC_008563.1.
DR AlphaFoldDB; A1AJW2; -.
DR BMRB; A1AJW2; -.
DR SMR; A1AJW2; -.
DR EnsemblBacteria; ABJ03952; ABJ03952; APECO1_1986.
DR GeneID; 66509929; -.
DR KEGG; ecv:APECO1_1986; -.
DR HOGENOM; CLU_147939_0_0_6; -.
DR OMA; GQMSQRE; -.
DR Proteomes; UP000008216; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1270.10; -; 1.
DR HAMAP; MF_00475; Trp_repressor; 1.
DR InterPro; IPR000831; Trp_repress.
DR InterPro; IPR013335; Trp_repress_bac.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR InterPro; IPR038116; TrpR-like_sf.
DR PANTHER; PTHR38025; PTHR38025; 1.
DR Pfam; PF01371; Trp_repressor; 1.
DR PIRSF; PIRSF003196; Trp_repressor; 1.
DR SUPFAM; SSF48295; SSF48295; 1.
DR TIGRFAMs; TIGR01321; TrpR; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..108
FT /note="Trp operon repressor"
FT /id="PRO_1000014038"
FT DNA_BIND 68..91
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00475"
SQ SEQUENCE 108 AA; 12341 MW; FDFF8A60EC4FE60E CRC64;
MAQQSPYSAA MAEQRHQEWL RFVDLLKNAY QNDLHLPLLN LMLTPDEREA LGTRVRIVEE
LLRGEMSQRE LKNELGAGIA TITRGSNSLK AAPVELRQWL EDVLLKSD