TRPR_ECOL5
ID TRPR_ECOL5 Reviewed; 108 AA.
AC Q0T8R8;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Trp operon repressor {ECO:0000255|HAMAP-Rule:MF_00475};
GN Name=trpR {ECO:0000255|HAMAP-Rule:MF_00475}; OrderedLocusNames=ECP_4779;
OS Escherichia coli O6:K15:H31 (strain 536 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=362663;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=536 / UPEC;
RX PubMed=16879640; DOI=10.1111/j.1365-2958.2006.05255.x;
RA Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U.,
RA Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.;
RT "Role of pathogenicity island-associated integrases in the genome
RT plasticity of uropathogenic Escherichia coli strain 536.";
RL Mol. Microbiol. 61:584-595(2006).
CC -!- FUNCTION: This protein is an aporepressor. When complexed with L-
CC tryptophan it binds the operator region of the trp operon (5'-
CC ACTAGT-'3') and prevents the initiation of transcription. The complex
CC also regulates trp repressor biosynthesis by binding to its regulatory
CC region. {ECO:0000255|HAMAP-Rule:MF_00475}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00475}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00475}.
CC -!- SIMILARITY: Belongs to the TrpR family. {ECO:0000255|HAMAP-
CC Rule:MF_00475}.
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DR EMBL; CP000247; ABG72661.1; -; Genomic_DNA.
DR RefSeq; WP_000068677.1; NC_008253.1.
DR AlphaFoldDB; Q0T8R8; -.
DR SMR; Q0T8R8; -.
DR STRING; 362663.ECP_4779; -.
DR EnsemblBacteria; ABG72661; ABG72661; ECP_4779.
DR GeneID; 66509929; -.
DR KEGG; ecp:ECP_4779; -.
DR HOGENOM; CLU_147939_0_0_6; -.
DR OMA; GQMSQRE; -.
DR Proteomes; UP000009182; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1270.10; -; 1.
DR HAMAP; MF_00475; Trp_repressor; 1.
DR InterPro; IPR000831; Trp_repress.
DR InterPro; IPR013335; Trp_repress_bac.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR InterPro; IPR038116; TrpR-like_sf.
DR PANTHER; PTHR38025; PTHR38025; 1.
DR Pfam; PF01371; Trp_repressor; 1.
DR PIRSF; PIRSF003196; Trp_repressor; 1.
DR SUPFAM; SSF48295; SSF48295; 1.
DR TIGRFAMs; TIGR01321; TrpR; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..108
FT /note="Trp operon repressor"
FT /id="PRO_1000014039"
FT DNA_BIND 68..91
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00475"
SQ SEQUENCE 108 AA; 12341 MW; FDFF8A60EC4FE60E CRC64;
MAQQSPYSAA MAEQRHQEWL RFVDLLKNAY QNDLHLPLLN LMLTPDEREA LGTRVRIVEE
LLRGEMSQRE LKNELGAGIA TITRGSNSLK AAPVELRQWL EDVLLKSD