TRPR_ENTCL
ID TRPR_ENTCL Reviewed; 109 AA.
AC P39440;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Trp operon repressor;
GN Name=trpR;
OS Enterobacter cloacae.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Enterobacter; Enterobacter cloacae complex.
OX NCBI_TaxID=550;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8208606; DOI=10.1093/nar/22.10.1821;
RA Arvidson D.N., Arvidson C.G., Lawson C.L., Miner J., Adams C.,
RA Youderian P.;
RT "The tryptophan repressor sequence is highly conserved among the
RT Enterobacteriaceae.";
RL Nucleic Acids Res. 22:1821-1829(1994).
CC -!- FUNCTION: This protein is an aporepressor. When complexed with L-
CC tryptophan it binds the operator region of the trp operon (5'-
CC ACTAGT-'3') and prevents the initiation of transcription. The complex
CC also regulates trp repressor biosynthesis by binding to its regulatory
CC region.
CC -!- SUBUNIT: Homodimer.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- SIMILARITY: Belongs to the TrpR family. {ECO:0000305}.
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DR EMBL; L26583; AAA20183.1; -; Unassigned_DNA.
DR PIR; S45257; S45257.
DR AlphaFoldDB; P39440; -.
DR SMR; P39440; -.
DR STRING; 1399774.JDWH01000001_gene2465; -.
DR eggNOG; COG2973; Bacteria.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1270.10; -; 1.
DR HAMAP; MF_00475; Trp_repressor; 1.
DR InterPro; IPR000831; Trp_repress.
DR InterPro; IPR013335; Trp_repress_bac.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR InterPro; IPR038116; TrpR-like_sf.
DR PANTHER; PTHR38025; PTHR38025; 1.
DR Pfam; PF01371; Trp_repressor; 1.
DR PIRSF; PIRSF003196; Trp_repressor; 1.
DR SUPFAM; SSF48295; SSF48295; 1.
DR TIGRFAMs; TIGR01321; TrpR; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..109
FT /note="Trp operon repressor"
FT /id="PRO_0000196498"
FT DNA_BIND 68..91
FT /evidence="ECO:0000250"
SQ SEQUENCE 109 AA; 12622 MW; A6806428222D9260 CRC64;
MTQHSPYSSA MAEQRHQEWL RFVELLRQSY DKDLHLPLLQ LMLTPDEREA LGTRVRIIEE
LLRGEMSQRE LKNELGAGIA TITRGSNSLK SAPVELRQWL EQILLGAQR