ID   TRPR_KLEAE              Reviewed;         108 AA.
AC   P39439;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Trp operon repressor;
GN   Name=trpR;
OS   Klebsiella aerogenes (Enterobacter aerogenes).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=548;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8208606; DOI=10.1093/nar/22.10.1821;
RA   Arvidson D.N., Arvidson C.G., Lawson C.L., Miner J., Adams C.,
RA   Youderian P.;
RT   "The tryptophan repressor sequence is highly conserved among the
RT   Enterobacteriaceae.";
RL   Nucleic Acids Res. 22:1821-1829(1994).
CC   -!- FUNCTION: This protein is an aporepressor. When complexed with L-
CC       tryptophan it binds the operator region of the trp operon (5'-
CC       ACTAGT-'3') and prevents the initiation of transcription. The complex
CC       also regulates trp repressor biosynthesis by binding to its regulatory
CC       region.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the TrpR family. {ECO:0000305}.
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DR   EMBL; L26582; AAC36892.1; -; Unassigned_DNA.
DR   PIR; S45254; S45254.
DR   RefSeq; WP_015368371.1; NZ_WPHE01000007.1.
DR   AlphaFoldDB; P39439; -.
DR   SMR; P39439; -.
DR   STRING; 548.EAG7_03372; -.
DR   OMA; GQMSQRE; -.
DR   OrthoDB; 1926997at2; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.1270.10; -; 1.
DR   HAMAP; MF_00475; Trp_repressor; 1.
DR   InterPro; IPR000831; Trp_repress.
DR   InterPro; IPR013335; Trp_repress_bac.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   InterPro; IPR038116; TrpR-like_sf.
DR   PANTHER; PTHR38025; PTHR38025; 1.
DR   Pfam; PF01371; Trp_repressor; 1.
DR   PIRSF; PIRSF003196; Trp_repressor; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   TIGRFAMs; TIGR01321; TrpR; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..108
FT                   /note="Trp operon repressor"
FT                   /id="PRO_0000196497"
FT   DNA_BIND        68..91
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   108 AA;  12353 MW;  3611AFD3820250E2 CRC64;
     MTQQSPYSAA VAEQRHQEWL RFVALLQQAY AEDLHLPLLQ LMLTPDEREA LGTRVRIIEE
     LLRGEMSQRE LKNELGAGIA TITRGSNSLK SAPVELRQWL EQTLLNDK