C1QL2_HUMAN
ID C1QL2_HUMAN Reviewed; 287 AA.
AC Q7Z5L3;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Complement C1q-like protein 2;
DE AltName: Full=C1q and tumor necrosis factor-related protein 10;
DE Short=C1q/TNF-related protein 10;
DE Flags: Precursor;
GN Name=C1QL2; Synonyms=CTRP10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Ding P., Han W., Wang Y., Rui M., Song Q., Zhang Y., Ma D.;
RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
CC -!- FUNCTION: May regulate the number of excitatory synapses that are
CC formed on hippocampus neurons. Has no effect on inhibitory synapses (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Forms homotrimers which can further assemble to form higher-
CC order oligomeric complexes. Interacts with ADGRB3. May interact with
CC ERFE. Forms heterooligomers with C1QL3 and C1QL4, when proteins are
CC coexpressed; this interaction does not occur after secretion.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
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DR EMBL; AF525315; AAP80787.1; -; mRNA.
DR EMBL; AC016673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS42737.1; -.
DR RefSeq; NP_872334.2; NM_182528.3.
DR AlphaFoldDB; Q7Z5L3; -.
DR SMR; Q7Z5L3; -.
DR BioGRID; 127912; 1.
DR STRING; 9606.ENSP00000272520; -.
DR TCDB; 8.A.94.1.6; the adiponectin (adiponectin) family.
DR BioMuta; C1QL2; -.
DR DMDM; 296434414; -.
DR MassIVE; Q7Z5L3; -.
DR PaxDb; Q7Z5L3; -.
DR PeptideAtlas; Q7Z5L3; -.
DR PRIDE; Q7Z5L3; -.
DR ProteomicsDB; 69319; -.
DR Antibodypedia; 58204; 105 antibodies from 21 providers.
DR DNASU; 165257; -.
DR Ensembl; ENST00000272520.4; ENSP00000272520.3; ENSG00000144119.4.
DR GeneID; 165257; -.
DR KEGG; hsa:165257; -.
DR MANE-Select; ENST00000272520.4; ENSP00000272520.3; NM_182528.4; NP_872334.2.
DR UCSC; uc002tlo.3; human.
DR CTD; 165257; -.
DR DisGeNET; 165257; -.
DR GeneCards; C1QL2; -.
DR HGNC; HGNC:24181; C1QL2.
DR HPA; ENSG00000144119; Tissue enriched (brain).
DR MIM; 614330; gene.
DR neXtProt; NX_Q7Z5L3; -.
DR OpenTargets; ENSG00000144119; -.
DR PharmGKB; PA134915960; -.
DR VEuPathDB; HostDB:ENSG00000144119; -.
DR eggNOG; ENOG502QUZ7; Eukaryota.
DR GeneTree; ENSGT00940000156913; -.
DR HOGENOM; CLU_001074_3_1_1; -.
DR InParanoid; Q7Z5L3; -.
DR OMA; TGAHYEM; -.
DR OrthoDB; 1320954at2759; -.
DR PhylomeDB; Q7Z5L3; -.
DR TreeFam; TF329591; -.
DR PathwayCommons; Q7Z5L3; -.
DR SignaLink; Q7Z5L3; -.
DR BioGRID-ORCS; 165257; 11 hits in 1060 CRISPR screens.
DR GenomeRNAi; 165257; -.
DR Pharos; Q7Z5L3; Tdark.
DR PRO; PR:Q7Z5L3; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q7Z5L3; protein.
DR Bgee; ENSG00000144119; Expressed in temporal lobe and 39 other tissues.
DR ExpressionAtlas; Q7Z5L3; baseline and differential.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF01391; Collagen; 1.
DR PRINTS; PR00007; COMPLEMNTC1Q.
DR SMART; SM00110; C1Q; 1.
DR SUPFAM; SSF49842; SSF49842; 1.
DR PROSITE; PS50871; C1Q; 1.
PE 2: Evidence at transcript level;
KW Collagen; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..287
FT /note="Complement C1q-like protein 2"
FT /id="PRO_0000274335"
FT DOMAIN 76..118
FT /note="Collagen-like"
FT DOMAIN 154..287
FT /note="C1q"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00368"
FT REGION 42..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..105
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 33..34
FT /note="CD -> WE (in Ref. 1; AAP80787)"
FT /evidence="ECO:0000305"
FT CONFLICT 50..51
FT /note="QP -> HN (in Ref. 1; AAP80787)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 287 AA; 29468 MW; F9F08EBF68F3C460 CRC64;
MALGLLIAVP LLLQAAPRGA AHYEMMGTCR MICDPYTAAP GGEPPGAKAQ PPGPSTAALE
VMQDLSANPP PPFIQGPKGD PGRPGKPGPR GPPGEPGPPG PRGPPGEKGD SGRPGLPGLQ
LTAGTASGVG VVGGGAGVGG DSEGEVTSAL SATFSGPKIA FYVGLKSPHE GYEVLKFDDV
VTNLGNHYDP TTGKFSCQVR GIYFFTYHIL MRGGDGTSMW ADLCKNGQVR ASAIAQDADQ
NYDYASNSVV LHLDSGDEVY VKLDGGKAHG GNNNKYSTFS GFLLYPD
