ID   TRPR_SALTY              Reviewed;         108 AA.
AC   P37444;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   31-JAN-2002, sequence version 2.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Trp operon repressor;
GN   Name=trpR; OrderedLocusNames=STM4583;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: This protein is an aporepressor. When complexed with L-
CC       tryptophan it binds the operator region of the trp operon (5'-
CC       ACTAGT-'3') and prevents the initiation of transcription. The complex
CC       also regulates trp repressor biosynthesis by binding to its regulatory
CC       region (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TrpR family. {ECO:0000305}.
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DR   EMBL; AE006468; AAL23398.1; -; Genomic_DNA.
DR   RefSeq; NP_463439.1; NC_003197.2.
DR   RefSeq; WP_000192003.1; NC_003197.2.
DR   AlphaFoldDB; P37444; -.
DR   SMR; P37444; -.
DR   STRING; 99287.STM4583; -.
DR   PaxDb; P37444; -.
DR   EnsemblBacteria; AAL23398; AAL23398; STM4583.
DR   GeneID; 1256109; -.
DR   KEGG; stm:STM4583; -.
DR   PATRIC; fig|99287.12.peg.4826; -.
DR   HOGENOM; CLU_147939_0_0_6; -.
DR   OMA; GQMSQRE; -.
DR   PhylomeDB; P37444; -.
DR   BioCyc; SENT99287:STM4583-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.1270.10; -; 1.
DR   HAMAP; MF_00475; Trp_repressor; 1.
DR   InterPro; IPR000831; Trp_repress.
DR   InterPro; IPR013335; Trp_repress_bac.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   InterPro; IPR038116; TrpR-like_sf.
DR   PANTHER; PTHR38025; PTHR38025; 1.
DR   Pfam; PF01371; Trp_repressor; 1.
DR   PIRSF; PIRSF003196; Trp_repressor; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   TIGRFAMs; TIGR01321; TrpR; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..108
FT                   /note="Trp operon repressor"
FT                   /id="PRO_0000196503"
FT   DNA_BIND        68..91
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   108 AA;  12391 MW;  A33FA182D498219D CRC64;
     MTQHSPYSSA IAEQRNQEWL RFVELLRQAY AEDLHLPLLQ LMLTPDEREA LGTRVRIIEE
     LLRGEMSQRE LKTELGAGIA TITRGSNSLK SAPVELRHWL ENVLLKNA