ID   TRPT1_DANRE             Reviewed;         225 AA.
AC   Q5EAR5;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=tRNA 2'-phosphotransferase 1;
DE            EC=2.7.1.160;
GN   Name=trpt1; ORFNames=zgc:113138;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the last step of tRNA splicing, the transfer of the
CC       splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-
CC       ribose 1''-2'' cyclic phosphate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2'-phospho-[ligated tRNA] + NAD(+) = ADP-beta-D-ribose
CC         1'',2''-cyclic phosphate + mature tRNA + nicotinamide;
CC         Xref=Rhea:RHEA:23324, Rhea:RHEA-COMP:11106, Rhea:RHEA-COMP:11107,
CC         ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:76596,
CC         ChEBI:CHEBI:82883, ChEBI:CHEBI:85027; EC=2.7.1.160;
CC   -!- SIMILARITY: Belongs to the KptA/TPT1 family. {ECO:0000305}.
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DR   EMBL; BC090282; AAH90282.2; -; mRNA.
DR   RefSeq; NP_001013309.2; NM_001013291.3.
DR   AlphaFoldDB; Q5EAR5; -.
DR   SMR; Q5EAR5; -.
DR   STRING; 7955.ENSDARP00000054802; -.
DR   PaxDb; Q5EAR5; -.
DR   Ensembl; ENSDART00000054803; ENSDARP00000054802; ENSDARG00000037628.
DR   GeneID; 503604; -.
DR   KEGG; dre:503604; -.
DR   CTD; 83707; -.
DR   ZFIN; ZDB-GENE-050227-16; trpt1.
DR   eggNOG; KOG2278; Eukaryota.
DR   GeneTree; ENSGT00390000002731; -.
DR   InParanoid; Q5EAR5; -.
DR   OMA; YLYHGTV; -.
DR   OrthoDB; 1460780at2759; -.
DR   PhylomeDB; Q5EAR5; -.
DR   TreeFam; TF324127; -.
DR   PRO; PR:Q5EAR5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 14.
DR   Bgee; ENSDARG00000037628; Expressed in testis and 26 other tissues.
DR   ExpressionAtlas; Q5EAR5; baseline.
DR   GO; GO:0000215; F:tRNA 2'-phosphotransferase activity; IBA:GO_Central.
DR   GO; GO:0008033; P:tRNA processing; IBA:GO_Central.
DR   GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; IBA:GO_Central.
DR   Gene3D; 1.10.10.970; -; 1.
DR   Gene3D; 3.20.170.30; -; 1.
DR   InterPro; IPR002745; Ptrans_KptA/Tpt1.
DR   InterPro; IPR042081; RNA_2'-PTrans_C.
DR   InterPro; IPR042080; RNA_2'-PTrans_N.
DR   PANTHER; PTHR12684; PTHR12684; 1.
DR   Pfam; PF01885; PTS_2-RNA; 1.
PE   2: Evidence at transcript level;
KW   NAD; Reference proteome; Transferase; tRNA processing.
FT   CHAIN           1..225
FT                   /note="tRNA 2'-phosphotransferase 1"
FT                   /id="PRO_0000273365"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   225 AA;  25539 MW;  F9C6E7DB923DC554 CRC64;
     MDCETRGRGR RGRGNRNEES RDVRLSKSLS YVLRHGASKM GLQMNSDGFV FVEELLAHQQ
     FRSFSVDDVE RVVASNDKQR FKLCKHPEDD RLQIRANQGH SVQVTDLELR EISQDDQDYP
     REAVHGSYMK HWPSIRSQGL SRMNRTHIHL APGLPGEGRV ISGMRQSCDL AVYIDVTKAM
     SDGIKFFWSE NGVLLTPGDA AGILAPCYFS RAQRLKPLPC DIELH