C1QRF_HUMAN
ID C1QRF_HUMAN Reviewed; 258 AA.
AC O75973;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=C1q-related factor;
DE AltName: Full=C1q and tumor necrosis factor-related protein 14;
DE Short=C1q/TNF-related protein 14;
DE AltName: Full=Complement component 1 Q subcomponent-like 1;
DE Flags: Precursor;
GN Name=C1QL1; Synonyms=C1QRF, CRF, CTRP14;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9878755; DOI=10.1016/s0169-328x(98)00278-2;
RA Berube N.G., Swanson X.H., Bertram M.J., Kittle J.D., Didenko V.,
RA Baskin D.S., Smith J.R., Pereira-Smith O.M.;
RT "Cloning and characterization of CRF, a novel C1q-related factor, expressed
RT in areas of the brain involved in motor function.";
RL Brain Res. Mol. Brain Res. 63:233-240(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG SeattleSNPs variation discovery resource;
RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May regulate the number of excitatory synapses that are
CC formed on hippocampus neurons. Has no effect on inhibitory synapses (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with ADGRB3. Forms heterooligomers with C1QL4, when
CC proteins are coexpressed; this interaction does not occur after
CC secretion. {ECO:0000250|UniProtKB:O88992}.
CC -!- INTERACTION:
CC O75973; P60827: C1QTNF8; NbExp=2; IntAct=EBI-10826419, EBI-10826404;
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed in brainstem.
CC -!- WEB RESOURCE: Name=SeattleSNPs;
CC URL="http://pga.gs.washington.edu/data/crf/";
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DR EMBL; AF095154; AAC64186.1; -; mRNA.
DR EMBL; AF410771; AAK95248.1; -; Genomic_DNA.
DR EMBL; BC008798; AAH08798.1; -; mRNA.
DR CCDS; CCDS11492.1; -.
DR RefSeq; NP_006679.1; NM_006688.4.
DR AlphaFoldDB; O75973; -.
DR SMR; O75973; -.
DR BioGRID; 116090; 39.
DR IntAct; O75973; 23.
DR STRING; 9606.ENSP00000253407; -.
DR iPTMnet; O75973; -.
DR PhosphoSitePlus; O75973; -.
DR BioMuta; C1QL1; -.
DR MassIVE; O75973; -.
DR MaxQB; O75973; -.
DR PaxDb; O75973; -.
DR PeptideAtlas; O75973; -.
DR PRIDE; O75973; -.
DR ProteomicsDB; 50335; -.
DR Antibodypedia; 29941; 66 antibodies from 16 providers.
DR DNASU; 10882; -.
DR Ensembl; ENST00000253407.4; ENSP00000253407.2; ENSG00000131094.4.
DR GeneID; 10882; -.
DR KEGG; hsa:10882; -.
DR MANE-Select; ENST00000253407.4; ENSP00000253407.2; NM_006688.5; NP_006679.1.
DR UCSC; uc002ihv.4; human.
DR CTD; 10882; -.
DR DisGeNET; 10882; -.
DR GeneCards; C1QL1; -.
DR HGNC; HGNC:24182; C1QL1.
DR HPA; ENSG00000131094; Tissue enriched (brain).
DR MIM; 611586; gene.
DR neXtProt; NX_O75973; -.
DR OpenTargets; ENSG00000131094; -.
DR PharmGKB; PA134951551; -.
DR VEuPathDB; HostDB:ENSG00000131094; -.
DR eggNOG; ENOG502QSKV; Eukaryota.
DR GeneTree; ENSGT00940000162478; -.
DR HOGENOM; CLU_001074_3_1_1; -.
DR InParanoid; O75973; -.
DR OMA; FTCAIPG; -.
DR OrthoDB; 1320954at2759; -.
DR PhylomeDB; O75973; -.
DR TreeFam; TF329591; -.
DR PathwayCommons; O75973; -.
DR SignaLink; O75973; -.
DR BioGRID-ORCS; 10882; 7 hits in 1066 CRISPR screens.
DR GeneWiki; C1QL1; -.
DR GenomeRNAi; 10882; -.
DR Pharos; O75973; Tdark.
DR PRO; PR:O75973; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; O75973; protein.
DR Bgee; ENSG00000131094; Expressed in amygdala and 132 other tissues.
DR Genevisible; O75973; HS.
DR GO; GO:0044301; C:climbing fiber; IEA:Ensembl.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0098793; C:presynapse; IEA:Ensembl.
DR GO; GO:0043083; C:synaptic cleft; IEA:Ensembl.
DR GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
DR GO; GO:0007626; P:locomotory behavior; NAS:UniProtKB.
DR GO; GO:0099558; P:maintenance of synapse structure; IEA:Ensembl.
DR GO; GO:0061743; P:motor learning; IEA:Ensembl.
DR GO; GO:0016322; P:neuron remodeling; IEA:Ensembl.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF01391; Collagen; 1.
DR PRINTS; PR00007; COMPLEMNTC1Q.
DR SMART; SM00110; C1Q; 1.
DR SUPFAM; SSF49842; SSF49842; 1.
DR PROSITE; PS50871; C1Q; 1.
PE 1: Evidence at protein level;
KW Collagen; Reference proteome; Secreted; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..258
FT /note="C1q-related factor"
FT /id="PRO_0000003527"
FT DOMAIN 67..115
FT /note="Collagen-like"
FT DOMAIN 125..258
FT /note="C1q"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00368"
FT REGION 39..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..109
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 258 AA; 26453 MW; 52C51CDF59CAE2BF CRC64;
MLLVLVVLIP VLVSSGGPEG HYEMLGTCRM VCDPYPARGP GAGARTDGGD ALSEQSGAPP
PSTLVQGPQG KPGRTGKPGP PGPPGDPGPP GPVGPPGEKG EPGKPGPPGL PGAGGSGAIS
TATYTTVPRV AFYAGLKNPH EGYEVLKFDD VVTNLGNNYD AASGKFTCNI PGTYFFTYHV
LMRGGDGTSM WADLCKNGQV RASAIAQDAD QNYDYASNSV ILHLDAGDEV FIKLDGGKAH
GGNSNKYSTF SGFIIYSD
