ID   TRSF_DROVI              Reviewed;         199 AA.
AC   Q24761;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Female-specific protein transformer;
GN   Name=tra;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=1592233; DOI=10.1093/genetics/131.1.113;
RA   O'Neil M.T., Belote J.M.;
RT   "Interspecific comparison of the transformer gene of Drosophila reveals an
RT   unusually high degree of evolutionary divergence.";
RL   Genetics 131:113-128(1992).
CC   -!- FUNCTION: Member of the regulatory pathway controlling female somatic
CC       sexual differentiation, regulated by Sxl. Activates dsx female-specific
CC       splicing by promoting the formation of a splicing enhancer complex
CC       which consists of tra, tra2 and sr proteins.
CC       {ECO:0000269|PubMed:1592233}.
CC   -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250}. Note=Speckled
CC       subnuclear compartment. {ECO:0000250}.
CC   -!- DOMAIN: RS domain directs localization of proteins to the speckled
CC       subnuclear compartment and the purpose of this localization is to allow
CC       colocalization and co-concentration of components of the splicing and
CC       splicing regulatory machinery to permit relatively high rates and/or
CC       efficiencies of reaction and interaction. {ECO:0000250}.
CC   -!- MISCELLANEOUS: The sexual regulation of tra occurs through a mechanism
CC       of sex-specific alternative RNA splicing. The non-sex-specific RNA
CC       expressed in males is not translated.
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DR   EMBL; X66528; CAA47141.1; -; Genomic_DNA.
DR   PIR; S26047; S26047.
DR   AlphaFoldDB; Q24761; -.
DR   eggNOG; ENOG502TAUK; Eukaryota.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0046660; P:female sex differentiation; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR   InterPro; IPR010519; Tra.
DR   Pfam; PF06495; Transformer; 1.
PE   3: Inferred from homology;
KW   Differentiation; Nucleus; Sexual differentiation.
FT   CHAIN           1..199
FT                   /note="Female-specific protein transformer"
FT                   /id="PRO_0000065647"
FT   REGION          1..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          178..199
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..41
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..117
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   199 AA;  23809 MW;  23655867BB539733 CRC64;
     MDADSSSRSP RDTRRRSRQR EKMPYFADEV RERDRVRNLP KLKTTQKRTP TPPRERRSRH
     ERPRSRSRTH SPEQSRCQRR LSRSYVRHRS GSRQKTYSSS CSRRRRSRSR SRSRGRSRTP
     RIITVPVPVP AAEYSYAYGW PPPRPHFNPM YGALPFGMQP RPLNPYFGAY ARPPPFRYRA
     GPFRPHPRYS YRNDRQAPN