C1QT1_MOUSE
ID C1QT1_MOUSE Reviewed; 281 AA.
AC Q9QXP7; Q80VI9;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Complement C1q tumor necrosis factor-related protein 1;
DE AltName: Full=Putative secreted protein ZSIG37;
DE Flags: Precursor;
GN Name=C1qtnf1; Synonyms=Zsig37;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Adipose tissue;
RX PubMed=15231994; DOI=10.1073/pnas.0403760101;
RA Wong G.W., Wang J., Hug C., Tsao T.S., Lodish H.F.;
RT "A family of Acrp30/adiponectin structural and functional paralogs.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:10302-10307(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Sheppard P., Deisher T., Grant F., Chen L., Haldeman B., McKnight G.,
RA Whitmore T., O'Hara P.;
RT "Mus musculus putative secreted protein.";
RL Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland, and Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; DQ002394; AAY21926.1; -; mRNA.
DR EMBL; AF192499; AAF06664.1; -; mRNA.
DR EMBL; AK005484; BAB24070.1; -; mRNA.
DR EMBL; AK145104; BAE26237.1; -; mRNA.
DR EMBL; AL591075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC049894; AAH49894.1; -; mRNA.
DR CCDS; CCDS25703.1; -.
DR RefSeq; NP_001191058.1; NM_001204129.1.
DR RefSeq; NP_001191059.1; NM_001204130.1.
DR RefSeq; NP_064343.1; NM_019959.3.
DR RefSeq; XP_006533884.1; XM_006533821.3.
DR RefSeq; XP_006533885.1; XM_006533822.3.
DR AlphaFoldDB; Q9QXP7; -.
DR SMR; Q9QXP7; -.
DR IntAct; Q9QXP7; 1.
DR STRING; 10090.ENSMUSP00000017590; -.
DR GlyGen; Q9QXP7; 1 site.
DR PhosphoSitePlus; Q9QXP7; -.
DR MaxQB; Q9QXP7; -.
DR PaxDb; Q9QXP7; -.
DR PeptideAtlas; Q9QXP7; -.
DR PRIDE; Q9QXP7; -.
DR ProteomicsDB; 265260; -.
DR Antibodypedia; 19749; 285 antibodies from 34 providers.
DR DNASU; 56745; -.
DR Ensembl; ENSMUST00000017590; ENSMUSP00000017590; ENSMUSG00000017446.
DR Ensembl; ENSMUST00000106286; ENSMUSP00000101893; ENSMUSG00000017446.
DR GeneID; 56745; -.
DR KEGG; mmu:56745; -.
DR UCSC; uc007mpg.2; mouse.
DR CTD; 114897; -.
DR MGI; MGI:1919254; C1qtnf1.
DR VEuPathDB; HostDB:ENSMUSG00000017446; -.
DR eggNOG; ENOG502QT5D; Eukaryota.
DR GeneTree; ENSGT00940000161333; -.
DR HOGENOM; CLU_001074_3_0_1; -.
DR InParanoid; Q9QXP7; -.
DR OMA; QCFRCCD; -.
DR OrthoDB; 1136568at2759; -.
DR PhylomeDB; Q9QXP7; -.
DR TreeFam; TF329591; -.
DR BioGRID-ORCS; 56745; 2 hits in 72 CRISPR screens.
DR ChiTaRS; C1qtnf1; mouse.
DR PRO; PR:Q9QXP7; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9QXP7; protein.
DR Bgee; ENSMUSG00000017446; Expressed in decidua and 143 other tissues.
DR ExpressionAtlas; Q9QXP7; baseline and differential.
DR Genevisible; Q9QXP7; MM.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; ISO:MGI.
DR GO; GO:0005518; F:collagen binding; ISO:MGI.
DR GO; GO:0042802; F:identical protein binding; IPI:MGI.
DR GO; GO:0010544; P:negative regulation of platelet activation; ISO:MGI.
DR GO; GO:0090331; P:negative regulation of platelet aggregation; ISO:MGI.
DR GO; GO:2000860; P:positive regulation of aldosterone secretion; ISO:MGI.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IDA:MGI.
DR GO; GO:0051897; P:positive regulation of protein kinase B signaling; IDA:MGI.
DR GO; GO:0010906; P:regulation of glucose metabolic process; IDA:MGI.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF01391; Collagen; 1.
DR PRINTS; PR00007; COMPLEMNTC1Q.
DR SMART; SM00110; C1Q; 1.
DR SUPFAM; SSF49842; SSF49842; 1.
DR PROSITE; PS50871; C1Q; 1.
PE 2: Evidence at transcript level;
KW Collagen; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..281
FT /note="Complement C1q tumor necrosis factor-related protein
FT 1"
FT /id="PRO_0000320081"
FT DOMAIN 99..140
FT /note="Collagen-like"
FT DOMAIN 141..281
FT /note="C1q"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00368"
FT REGION 35..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 93
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 9
FT /note="M -> L (in Ref. 3; BAE26237 and 5; AAH49894)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 281 AA; 32009 MW; C9816216DB6419E2 CRC64;
MGSCAQGFML GCCLLLAITW GPILSLVPRV QEEQQEWEET EELPSPLDPV TRPEETREKY
SPRQGEDLPT SRCYRCCDPS TPVYQTIPPP QINITILKGE KGDRGDRGLQ GKYGKIGSTG
PRGHVGPKGQ KGSIGAPGNH CKSQYAAFSV GRKKALHSND YFQPVVFDTE FVNLYKHFNM
FTGKFYCYVP GIYFFSLNVH TWNQKETYLH IMKNEEEVVI LYAQVSDRSI MQSQSLMMEL
REEDEVWVRL FKGERENAIF SDEFDTYITF SGYLVKPASE P
