ACATN_RAT
ID ACATN_RAT Reviewed; 550 AA.
AC Q6AYY8; Q9JM68;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Acetyl-coenzyme A transporter 1;
DE Short=AT-1;
DE Short=Acetyl-CoA transporter 1;
DE AltName: Full=Solute carrier family 33 member 1;
GN Name=Slc33a1; Synonyms=Acatn;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=Wistar; TISSUE=Embryonic brain;
RX PubMed=10965123; DOI=10.1159/000015613;
RA Bora R.S., Ichikawa S., Kanamori A., Hirabayashi Y.;
RT "cDNA cloning of putative rat acetyl-CoA transporter and its expression
RT pattern in brain.";
RL Cytogenet. Cell Genet. 89:204-208(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable acetyl-CoA transporter necessary for O-acetylation
CC of gangliosides. Negatively regulates BMP signaling (By similarity).
CC {ECO:0000250|UniProtKB:O00400}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in brain at all developmental stages.
CC Detected in hippocampus, hypothalamus, cerebellum, cortex, olfactory
CC bulb, and the ventral and dorsal anterior olfactory nucleus.
CC {ECO:0000269|PubMed:10965123}.
CC -!- SIMILARITY: Belongs to the SLC33A transporter family. {ECO:0000305}.
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DR EMBL; AB039326; BAA95446.1; -; Genomic_DNA.
DR EMBL; BC078832; AAH78832.1; -; mRNA.
DR RefSeq; NP_071588.2; NM_022252.2.
DR RefSeq; XP_008759280.1; XM_008761058.1.
DR AlphaFoldDB; Q6AYY8; -.
DR STRING; 10116.ENSRNOP00000013392; -.
DR GlyGen; Q6AYY8; 1 site.
DR iPTMnet; Q6AYY8; -.
DR PhosphoSitePlus; Q6AYY8; -.
DR PaxDb; Q6AYY8; -.
DR Ensembl; ENSRNOT00000013392; ENSRNOP00000013392; ENSRNOG00000010023.
DR GeneID; 64018; -.
DR KEGG; rno:64018; -.
DR UCSC; RGD:620653; rat.
DR CTD; 9197; -.
DR RGD; 620653; Slc33a1.
DR VEuPathDB; HostDB:ENSRNOG00000051151; -.
DR eggNOG; KOG3574; Eukaryota.
DR GeneTree; ENSGT00940000154019; -.
DR HOGENOM; CLU_020502_1_0_1; -.
DR InParanoid; Q6AYY8; -.
DR OMA; LWFWGIT; -.
DR OrthoDB; 1300300at2759; -.
DR PhylomeDB; Q6AYY8; -.
DR TreeFam; TF300008; -.
DR Reactome; R-RNO-425397; Transport of vitamins, nucleosides, and related molecules.
DR PRO; PR:Q6AYY8; -.
DR Proteomes; UP000002494; Chromosome 2.
DR Bgee; ENSRNOG00000010023; Expressed in liver and 20 other tissues.
DR Genevisible; Q6AYY8; RN.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008521; F:acetyl-CoA transmembrane transporter activity; NAS:RGD.
DR GO; GO:0015295; F:solute:proton symporter activity; IBA:GO_Central.
DR GO; GO:0030509; P:BMP signaling pathway; ISO:RGD.
DR GO; GO:0007417; P:central nervous system development; NAS:RGD.
DR GO; GO:0060395; P:SMAD protein signal transduction; ISO:RGD.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR024371; AcetylCoA_trans_1-like.
DR InterPro; IPR004752; AmpG_permease/AT-1.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR12778; PTHR12778; 1.
DR Pfam; PF13000; Acatn; 2.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Glycoprotein; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..550
FT /note="Acetyl-coenzyme A transporter 1"
FT /id="PRO_0000076167"
FT TOPO_DOM 1..74
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..113
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 135..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..256
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 278..300
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 322..344
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 345..365
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 366..375
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 397..405
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 406..426
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 427..509
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 510..530
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 531..550
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT MOD_RES 42
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q99J27"
FT CARBOHYD 103
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 245
FT /note="L -> W (in Ref. 1; BAA95446)"
FT /evidence="ECO:0000305"
FT CONFLICT 549
FT /note="T -> N (in Ref. 1; BAA95446)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 550 AA; 61101 MW; 1CAE30DDDD5D1254 CRC64;
MSPTISHKDN SRQRRSGMFG HALDMKSGPL PPGGWDDNHQ DSVGGEGDRE VLLGDVGPGD
FPKAKRSYRA ELSSILLLLF LYVLQGIPLG LAGSIPLILQ SKNVSYTDQA FFSFVFWPFS
LKLLWAPLVD AVYFKNFGRR KSWLVPTQYI LGIFMIYLST QVDRLLGNID GRTPDVVALT
VTFFLFEFLA ATQDIAVDGW ALTMLSRENV GYASTCNSVG QTAGYFLGNV LFLALESADF
CNKYLRFQPQ PRGIVTLSDF LFFWGTVFLI TTTLVALLKK ETREASVVKE ETQGITDTYK
LLFSIIKMPA VLAFCLLILT SKIGFSAADA VTGLKLVEEG VPKEHLALLA VPMVPLQIIL
PLLISKYTAG PQPLNIFYKA MPYRLLLGLE YALLVWWTPK VEHQGGFPIY YYIIVLLSYA
LHQVTLYSMY VSIMAFNAKV SDPLIGGTYM TLLNTVSNLG GNWPSTVALW LVDPLTVKEC
VGASNQNCRT PEAIELCKKL GGSCVTALDG YYVESIVCVL IGFGWWFFLG PKFKKLQDEG
PSSWKCKRTN
