ID   C1QT1_RAT               Reviewed;         281 AA.
AC   Q5XIG2;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Complement C1q tumor necrosis factor-related protein 1;
DE   Flags: Precursor;
GN   Name=C1qtnf1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR   EMBL; BC083720; AAH83720.1; -; mRNA.
DR   RefSeq; NP_001007676.1; NM_001007675.1.
DR   RefSeq; XP_006247863.1; XM_006247801.3.
DR   RefSeq; XP_006247864.1; XM_006247802.3.
DR   RefSeq; XP_017452836.1; XM_017597347.1.
DR   AlphaFoldDB; Q5XIG2; -.
DR   SMR; Q5XIG2; -.
DR   STRING; 10116.ENSRNOP00000004373; -.
DR   GlyGen; Q5XIG2; 1 site.
DR   PaxDb; Q5XIG2; -.
DR   Ensembl; ENSRNOT00000087404; ENSRNOP00000070390; ENSRNOG00000003259.
DR   GeneID; 303701; -.
DR   KEGG; rno:303701; -.
DR   UCSC; RGD:1359204; rat.
DR   CTD; 114897; -.
DR   RGD; 1359204; C1qtnf1.
DR   eggNOG; ENOG502QT5D; Eukaryota.
DR   GeneTree; ENSGT00940000161333; -.
DR   HOGENOM; CLU_001074_3_0_1; -.
DR   InParanoid; Q5XIG2; -.
DR   PhylomeDB; Q5XIG2; -.
DR   TreeFam; TF329591; -.
DR   PRO; PR:Q5XIG2; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000003259; Expressed in esophagus and 19 other tissues.
DR   ExpressionAtlas; Q5XIG2; baseline and differential.
DR   Genevisible; Q5XIG2; RN.
DR   GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR   GO; GO:0005615; C:extracellular space; ISO:RGD.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISO:RGD.
DR   GO; GO:0005518; F:collagen binding; ISO:RGD.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0010544; P:negative regulation of platelet activation; ISO:RGD.
DR   GO; GO:0090331; P:negative regulation of platelet aggregation; ISO:RGD.
DR   GO; GO:2000860; P:positive regulation of aldosterone secretion; ISO:RGD.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:RGD.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; ISO:RGD.
DR   GO; GO:0051897; P:positive regulation of protein kinase B signaling; ISO:RGD.
DR   GO; GO:0010906; P:regulation of glucose metabolic process; ISO:RGD.
DR   Gene3D; 2.60.120.40; -; 1.
DR   InterPro; IPR001073; C1q_dom.
DR   InterPro; IPR008160; Collagen.
DR   InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR   Pfam; PF00386; C1q; 1.
DR   Pfam; PF01391; Collagen; 1.
DR   PRINTS; PR00007; COMPLEMNTC1Q.
DR   SMART; SM00110; C1Q; 1.
DR   SUPFAM; SSF49842; SSF49842; 1.
DR   PROSITE; PS50871; C1Q; 1.
PE   2: Evidence at transcript level;
KW   Collagen; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..281
FT                   /note="Complement C1q tumor necrosis factor-related protein
FT                   1"
FT                   /id="PRO_0000320082"
FT   DOMAIN          99..140
FT                   /note="Collagen-like"
FT   DOMAIN          141..281
FT                   /note="C1q"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00368"
FT   REGION          36..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          107..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        42..62
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        93
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   281 AA;  32042 MW;  BDCEF78BA9FC1336 CRC64;
     MGSRGQGFML GCCLLLAVTW GPVLSLVPRV QEEQQEWEET EELTSPLDHV TRPEETHKRY
     SPSLREGLPT SRCYRCCDSN PPVYQTIPPP QINITILKGE KGDRGDRGLQ GKYGKIGSTG
     PRGHIGPKGQ KGSMGAPGDH CKSQYAAFSV GRKKALHSND YFQPVVFDTE FVNLYNHFNM
     FTGKFYCYVP GIYFFSLNVH TWNQKETYLH IMKNEEEVVI LYAQVSDRSI MQSQSLMLEL
     REQDEVWVRL FKGERENAIF SDEFDTYITF SGYLVKPASE P