C1QT3_MOUSE
ID C1QT3_MOUSE Reviewed; 246 AA.
AC Q9ES30;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Complement C1q tumor necrosis factor-related protein 3;
DE AltName: Full=Collagenous repeat-containing sequence 26 kDa protein;
DE Short=CORS26;
DE AltName: Full=Secretory protein CORS26;
DE Flags: Precursor;
GN Name=C1qtnf3; Synonyms=Cors26, Ctrp3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11071891; DOI=10.1074/jbc.m007898200;
RA Maeda T., Abe M., Kurisu K., Jikko A., Furukawa S.;
RT "Molecular cloning and characterization of a novel gene, CORS26, encoding a
RT putative secretory protein and its possible involvement in skeletal
RT development.";
RL J. Biol. Chem. 276:3628-3634(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N, and FVB/N-3; TISSUE=Kidney, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF246265; AAG33704.1; -; mRNA.
DR EMBL; AK029352; BAC26412.1; -; mRNA.
DR EMBL; AK075867; BAC36016.1; -; mRNA.
DR EMBL; AK081704; BAC38301.1; -; mRNA.
DR EMBL; BC055047; AAH55047.1; -; mRNA.
DR EMBL; BC055859; AAH55859.1; -; mRNA.
DR CCDS; CCDS27380.1; -.
DR RefSeq; NP_112150.1; NM_030888.4.
DR AlphaFoldDB; Q9ES30; -.
DR SMR; Q9ES30; -.
DR PhosphoSitePlus; Q9ES30; -.
DR MaxQB; Q9ES30; -.
DR PaxDb; Q9ES30; -.
DR PRIDE; Q9ES30; -.
DR ProteomicsDB; 265399; -.
DR Ensembl; ENSMUST00000022853; ENSMUSP00000022853; ENSMUSG00000058914.
DR GeneID; 81799; -.
DR KEGG; mmu:81799; -.
DR UCSC; uc007vgu.2; mouse.
DR CTD; 114899; -.
DR MGI; MGI:1932136; C1qtnf3.
DR VEuPathDB; HostDB:ENSMUSG00000058914; -.
DR eggNOG; ENOG502QSK2; Eukaryota.
DR GeneTree; ENSGT00940000161378; -.
DR HOGENOM; CLU_001074_0_1_1; -.
DR InParanoid; Q9ES30; -.
DR OMA; GNEVHSN; -.
DR PhylomeDB; Q9ES30; -.
DR BioGRID-ORCS; 81799; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q9ES30; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q9ES30; protein.
DR Bgee; ENSMUSG00000058914; Expressed in humerus cartilage element and 135 other tissues.
DR ExpressionAtlas; Q9ES30; baseline and differential.
DR Genevisible; Q9ES30; MM.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0032991; C:protein-containing complex; IDA:MGI.
DR GO; GO:0042802; F:identical protein binding; IDA:MGI.
DR GO; GO:0035356; P:cellular triglyceride homeostasis; ISO:MGI.
DR GO; GO:0070371; P:ERK1 and ERK2 cascade; IDA:MGI.
DR GO; GO:0042593; P:glucose homeostasis; IDA:MGI.
DR GO; GO:0010629; P:negative regulation of gene expression; ISO:MGI.
DR GO; GO:0045721; P:negative regulation of gluconeogenesis; IDA:MGI.
DR GO; GO:0050728; P:negative regulation of inflammatory response; ISO:MGI.
DR GO; GO:0032715; P:negative regulation of interleukin-6 production; ISO:MGI.
DR GO; GO:0071638; P:negative regulation of monocyte chemotactic protein-1 production; ISO:MGI.
DR GO; GO:1901223; P:negative regulation of NIK/NF-kappaB signaling; ISO:MGI.
DR GO; GO:0070165; P:positive regulation of adiponectin secretion; IDA:UniProtKB.
DR GO; GO:0001819; P:positive regulation of cytokine production; IDA:UniProtKB.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:MGI.
DR GO; GO:0051897; P:positive regulation of protein kinase B signaling; IDA:MGI.
DR GO; GO:0043491; P:protein kinase B signaling; IDA:MGI.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF01391; Collagen; 1.
DR PRINTS; PR00007; COMPLEMNTC1Q.
DR SMART; SM00110; C1Q; 1.
DR SUPFAM; SSF49842; SSF49842; 1.
DR PROSITE; PS50871; C1Q; 1.
PE 2: Evidence at transcript level;
KW Collagen; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..246
FT /note="Complement C1q tumor necrosis factor-related protein
FT 3"
FT /id="PRO_0000003532"
FT DOMAIN 51..113
FT /note="Collagen-like"
FT DOMAIN 113..246
FT /note="C1q"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00368"
FT REGION 53..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..104
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 246 AA; 26828 MW; 42A481B3E9F48F7E CRC64;
MLGRQRIWWH LLPLLFLPFC LCQDEYMESP QAGGLPPDCS KCCHGDYGFR GYQGPPGPPG
PPGIPGNHGN NGNNGATGHE GAKGEKGDKG DLGPRGERGQ HGPKGEKGYP GVPPELQIAF
MASLATHFSN QNSGIIFSSV ETNIGNFFDV MTGRFGAPVS GVYFFTFSMM KHEDVEEVYV
YLMHNGNTVF SMYSYETKGK SDTSSNHAVL KLAKGDEVWL RMGNGALHGD HQRFSTFAGF
LLFETK
