C1QT5_MOUSE
ID C1QT5_MOUSE Reviewed; 243 AA.
AC Q8K479;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Complement C1q tumor necrosis factor-related protein 5;
DE Flags: Precursor;
GN Name=C1qtnf5; Synonyms=Ctrp5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=12140190; DOI=10.1093/hmg/11.16.1879;
RA Kameya S., Hawes N.L., Chang B., Heckenlively J.R., Naggert J.K.,
RA Nishina P.M.;
RT "Mfrp, a gene encoding a frizzled related protein, is mutated in the mouse
RT retinal degeneration 6.";
RL Hum. Mol. Genet. 11:1879-1886(2002).
RN [2]
RP INTERACTION WITH ERFE.
RX PubMed=22351773; DOI=10.1074/jbc.m111.336834;
RA Seldin M.M., Peterson J.M., Byerly M.S., Wei Z., Wong G.W.;
RT "Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic
RT lipid homeostasis.";
RL J. Biol. Chem. 287:11968-11980(2012).
CC -!- SUBUNIT: Homotrimer (via collagen-like domain). May form higher order
CC oligomers by supercoiling of the trimers (By similarity). May interact
CC with ERFE. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; AF469650; AAM89217.1; -; mRNA.
DR CCDS; CCDS52777.1; -.
DR RefSeq; NP_001035721.1; NM_001040631.2.
DR RefSeq; NP_001035722.1; NM_001040632.2.
DR RefSeq; NP_001177242.1; NM_001190313.1.
DR RefSeq; NP_001177248.1; NM_001190319.1.
DR RefSeq; NP_663588.2; NM_145613.4.
DR AlphaFoldDB; Q8K479; -.
DR SMR; Q8K479; -.
DR STRING; 10090.ENSMUSP00000110464; -.
DR PhosphoSitePlus; Q8K479; -.
DR MaxQB; Q8K479; -.
DR PaxDb; Q8K479; -.
DR PRIDE; Q8K479; -.
DR ProteomicsDB; 265461; -.
DR Antibodypedia; 32683; 275 antibodies from 34 providers.
DR DNASU; 235312; -.
DR Ensembl; ENSMUST00000114815; ENSMUSP00000110463; ENSMUSG00000079592.
DR Ensembl; ENSMUST00000114816; ENSMUSP00000110464; ENSMUSG00000079592.
DR Ensembl; ENSMUST00000114818; ENSMUSP00000110466; ENSMUSG00000079592.
DR Ensembl; ENSMUST00000114821; ENSMUSP00000110469; ENSMUSG00000079592.
DR GeneID; 235312; -.
DR KEGG; mmu:235312; -.
DR UCSC; uc009pbs.2; mouse.
DR CTD; 114902; -.
DR MGI; MGI:2385958; C1qtnf5.
DR VEuPathDB; HostDB:ENSMUSG00000079592; -.
DR eggNOG; ENOG502QUEA; Eukaryota.
DR GeneTree; ENSGT00940000161353; -.
DR HOGENOM; CLU_001074_0_2_1; -.
DR InParanoid; Q8K479; -.
DR OMA; YWQNSAV; -.
DR PhylomeDB; Q8K479; -.
DR TreeFam; TF329591; -.
DR BioGRID-ORCS; 235312; 1 hit in 39 CRISPR screens.
DR ChiTaRS; C1qtnf5; mouse.
DR PRO; PR:Q8K479; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8K479; protein.
DR Bgee; ENSMUSG00000079592; Expressed in vasculature of organ and 61 other tissues.
DR ExpressionAtlas; Q8K479; baseline.
DR Genevisible; Q8K479; MM.
DR GO; GO:0016324; C:apical plasma membrane; IDA:MGI.
DR GO; GO:0005923; C:bicellular tight junction; IDA:MGI.
DR GO; GO:0042995; C:cell projection; IDA:MGI.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0016328; C:lateral plasma membrane; IDA:MGI.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0032991; C:protein-containing complex; IDA:MGI.
DR GO; GO:0030133; C:transport vesicle; IDA:MGI.
DR GO; GO:0042802; F:identical protein binding; IDA:MGI.
DR GO; GO:0048839; P:inner ear development; IDA:MGI.
DR GO; GO:0009306; P:protein secretion; IMP:MGI.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF01391; Collagen; 1.
DR PRINTS; PR00007; COMPLEMNTC1Q.
DR SMART; SM00110; C1Q; 1.
DR SUPFAM; SSF49842; SSF49842; 1.
DR PROSITE; PS50871; C1Q; 1.
PE 1: Evidence at protein level;
KW Collagen; Reference proteome; Secreted; Signal.
FT SIGNAL 1..15
FT /evidence="ECO:0000250"
FT CHAIN 16..243
FT /note="Complement C1q tumor necrosis factor-related protein
FT 5"
FT /id="PRO_0000003536"
FT DOMAIN 30..95
FT /note="Collagen-like"
FT DOMAIN 99..238
FT /note="C1q"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00368"
FT REGION 15..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 243 AA; 25437 MW; 9F4D5804349791D9 CRC64;
MRPLLALLLL GLVSGSPPLD DNKIPSLCPG QPGLPGTPGH HGSQGLPGRD GRDGRDGAPG
APGEKGEGGR PGLPGPRGEP GPRGEAGPMG AIGPAGECSV PPRSAFSAKR SESRVPPPAD
TPLPFDRVLL NEQGHYDPTT GKFTCQVPGV YYFAVHATVY RASLQFDLVK NGQSIASFFQ
YFGGWPKPAS LSGGAMVRLE PEDQVWVQVG VGDYIGIYAS IKTDSTFSGF LVYSDWHSSP
VFA
