C1QT5_RAT
ID C1QT5_RAT Reviewed; 243 AA.
AC Q5FVH0;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Complement C1q tumor necrosis factor-related protein 5;
DE Flags: Precursor;
GN Name=C1qtnf5; Synonyms=Ctrp5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Homotrimer (via collagen-like domain). May form higher order
CC oligomers by supercoiling of the trimers. May interact with ERFE (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; BC089992; AAH89992.1; -; mRNA.
DR RefSeq; NP_001012123.1; NM_001012123.1.
DR RefSeq; XP_017451111.1; XM_017595622.1.
DR AlphaFoldDB; Q5FVH0; -.
DR SMR; Q5FVH0; -.
DR IntAct; Q5FVH0; 1.
DR STRING; 10116.ENSRNOP00000010127; -.
DR PhosphoSitePlus; Q5FVH0; -.
DR PaxDb; Q5FVH0; -.
DR PRIDE; Q5FVH0; -.
DR Ensembl; ENSRNOT00000010127; ENSRNOP00000010127; ENSRNOG00000007613.
DR GeneID; 315598; -.
DR KEGG; rno:315598; -.
DR UCSC; RGD:1308802; rat.
DR CTD; 114902; -.
DR RGD; 1308802; C1qtnf5.
DR eggNOG; ENOG502QUEA; Eukaryota.
DR GeneTree; ENSGT00940000161353; -.
DR HOGENOM; CLU_001074_0_2_1; -.
DR InParanoid; Q5FVH0; -.
DR OMA; YWQNSAV; -.
DR OrthoDB; 1258047at2759; -.
DR PhylomeDB; Q5FVH0; -.
DR TreeFam; TF329591; -.
DR PRO; PR:Q5FVH0; -.
DR Proteomes; UP000002494; Chromosome 8.
DR Bgee; ENSRNOG00000007613; Expressed in ovary and 19 other tissues.
DR ExpressionAtlas; Q5FVH0; baseline and differential.
DR Genevisible; Q5FVH0; RN.
DR GO; GO:0016324; C:apical plasma membrane; ISO:RGD.
DR GO; GO:0005923; C:bicellular tight junction; ISO:RGD.
DR GO; GO:0042995; C:cell projection; ISO:RGD.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; ISO:RGD.
DR GO; GO:0005615; C:extracellular space; ISO:RGD.
DR GO; GO:0016328; C:lateral plasma membrane; ISO:RGD.
DR GO; GO:0016020; C:membrane; ISO:RGD.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0032991; C:protein-containing complex; ISO:RGD.
DR GO; GO:0030133; C:transport vesicle; ISO:RGD.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0048839; P:inner ear development; ISO:RGD.
DR GO; GO:0009306; P:protein secretion; ISO:RGD.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF01391; Collagen; 2.
DR PRINTS; PR00007; COMPLEMNTC1Q.
DR SMART; SM00110; C1Q; 1.
DR SUPFAM; SSF49842; SSF49842; 1.
DR PROSITE; PS50871; C1Q; 1.
PE 2: Evidence at transcript level;
KW Collagen; Reference proteome; Secreted; Signal.
FT SIGNAL 1..15
FT /evidence="ECO:0000250"
FT CHAIN 16..243
FT /note="Complement C1q tumor necrosis factor-related protein
FT 5"
FT /id="PRO_0000003537"
FT DOMAIN 30..95
FT /note="Collagen-like"
FT DOMAIN 99..238
FT /note="C1q"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00368"
FT REGION 15..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 243 AA; 25334 MW; 178AB5F39D52B041 CRC64;
MRPLLALLLL GLASGSPPLD DNKIPSLCPG QPGLPGTPGH HGSQGLPGRD GRDGRDGAPG
APGEKGEGGR PGLPGPRGEP GPRGEAGPVG AIGPAGECSV PPRSAFSAKR SESRVPPPAD
TPLPFDRVLL NEQGHYDATT GKFTCQVPGV YYFAVHATVY RASLQFDLVK NGQSIASFFQ
FFGGWPKPAS LSGGAMVRLE PEDQVWVQVG VGDYIGIYAS IKTDSTFSGF LVYSDWHSSP
VFA