C1QT6_MOUSE
ID C1QT6_MOUSE Reviewed; 264 AA.
AC Q6IR41; Q8BKR0;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Complement C1q tumor necrosis factor-related protein 6;
DE Flags: Precursor;
GN Name=C1qtnf6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Adipose tissue;
RX PubMed=15231994; DOI=10.1073/pnas.0403760101;
RA Wong G.W., Wang J., Hug C., Tsao T.S., Lodish H.F.;
RT "A family of Acrp30/adiponectin structural and functional paralogs.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:10302-10307(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DQ002399; AAY21931.1; -; mRNA.
DR EMBL; AK051058; BAC34512.1; -; mRNA.
DR EMBL; AK154407; BAE32564.1; -; mRNA.
DR EMBL; AL590144; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC071187; AAH71187.1; -; mRNA.
DR CCDS; CCDS37134.1; -.
DR RefSeq; NP_082607.3; NM_028331.5.
DR AlphaFoldDB; Q6IR41; -.
DR SMR; Q6IR41; -.
DR STRING; 10090.ENSMUSP00000023075; -.
DR GlyGen; Q6IR41; 1 site.
DR PhosphoSitePlus; Q6IR41; -.
DR MaxQB; Q6IR41; -.
DR PaxDb; Q6IR41; -.
DR PRIDE; Q6IR41; -.
DR ProteomicsDB; 273805; -.
DR Antibodypedia; 1088; 284 antibodies from 30 providers.
DR DNASU; 72709; -.
DR Ensembl; ENSMUST00000023075; ENSMUSP00000023075; ENSMUSG00000022440.
DR GeneID; 72709; -.
DR KEGG; mmu:72709; -.
DR UCSC; uc007wpn.2; mouse.
DR CTD; 114904; -.
DR MGI; MGI:1919959; C1qtnf6.
DR VEuPathDB; HostDB:ENSMUSG00000022440; -.
DR eggNOG; ENOG502QT5D; Eukaryota.
DR GeneTree; ENSGT00940000160396; -.
DR HOGENOM; CLU_001074_3_0_1; -.
DR InParanoid; Q6IR41; -.
DR OMA; TKGAKGQ; -.
DR OrthoDB; 1136568at2759; -.
DR PhylomeDB; Q6IR41; -.
DR TreeFam; TF329591; -.
DR BioGRID-ORCS; 72709; 2 hits in 74 CRISPR screens.
DR ChiTaRS; C1qtnf6; mouse.
DR PRO; PR:Q6IR41; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q6IR41; protein.
DR Bgee; ENSMUSG00000022440; Expressed in humerus cartilage element and 129 other tissues.
DR ExpressionAtlas; Q6IR41; baseline and differential.
DR Genevisible; Q6IR41; MM.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0032991; C:protein-containing complex; IDA:MGI.
DR GO; GO:0042802; F:identical protein binding; IDA:MGI.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF01391; Collagen; 1.
DR PRINTS; PR00007; COMPLEMNTC1Q.
DR SMART; SM00110; C1Q; 1.
DR SUPFAM; SSF49842; SSF49842; 1.
DR PROSITE; PS50871; C1Q; 1.
PE 2: Evidence at transcript level;
KW Collagen; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..264
FT /note="Complement C1q tumor necrosis factor-related protein
FT 6"
FT /id="PRO_0000320084"
FT DOMAIN 83..124
FT /note="Collagen-like"
FT DOMAIN 125..264
FT /note="C1q"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00368"
FT REGION 81..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 77
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 106
FT /note="R -> H (in Ref. 2; BAC34512)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 264 AA; 29081 MW; 89C61B07C65A2CD8 CRC64;
MRVIMGIASL GFLWAVFLLP LVFGVPTEET TFGESVASHL PKGCRRCCDP EDLMSSDDTV
QAPVSPYVLP EVRPYINITI LKGDKGDRGP TGTPGKPGKN GTRGDRGSQG VKGDKGQAGS
PGSSCQTHYS AFSVGRKTGL HSSENFLSLL FDRVFVNTDG HFDMATGSFV APLRGLYFFS
LNVHSWNYKE TYVHIVHNEQ AVVILYAQPS ERSIMQSQSV MLPLVPGDRV WVRLFKRERE
NGIYSDDVDT YITFSGHLIK AEDN
