C1QT7_HUMAN
ID C1QT7_HUMAN Reviewed; 289 AA.
AC Q9BXJ2; B2RBT3; J3KPW3;
DT 16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Complement C1q tumor necrosis factor-related protein 7;
DE Flags: Precursor;
GN Name=C1QTNF7; Synonyms=CTRP7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Piddington C.S., Sheppard P.O., Bishop P., Lasser G.W.;
RT "Homo sapiens complement-c1q tumor necrosis factor-related protein.";
RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BXJ2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BXJ2-2; Sequence=VSP_046778;
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DR EMBL; AF329839; AAK17963.1; -; mRNA.
DR EMBL; AK314802; BAG37330.1; -; mRNA.
DR EMBL; BX647781; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC007016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC099550; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC022187; AAH22187.1; -; mRNA.
DR EMBL; BC024015; AAH24015.1; -; mRNA.
DR CCDS; CCDS3414.1; -. [Q9BXJ2-1]
DR CCDS; CCDS47025.1; -. [Q9BXJ2-2]
DR RefSeq; NP_001128642.1; NM_001135170.1. [Q9BXJ2-2]
DR RefSeq; NP_001128643.1; NM_001135171.1. [Q9BXJ2-1]
DR RefSeq; NP_114117.1; NM_031911.4. [Q9BXJ2-1]
DR RefSeq; XP_011512074.1; XM_011513772.1. [Q9BXJ2-2]
DR RefSeq; XP_011512075.1; XM_011513773.1. [Q9BXJ2-1]
DR AlphaFoldDB; Q9BXJ2; -.
DR SMR; Q9BXJ2; -.
DR BioGRID; 125394; 144.
DR STRING; 9606.ENSP00000295297; -.
DR iPTMnet; Q9BXJ2; -.
DR PhosphoSitePlus; Q9BXJ2; -.
DR BioMuta; C1QTNF7; -.
DR DMDM; 20177863; -.
DR MassIVE; Q9BXJ2; -.
DR PaxDb; Q9BXJ2; -.
DR PeptideAtlas; Q9BXJ2; -.
DR PRIDE; Q9BXJ2; -.
DR ProteomicsDB; 79434; -. [Q9BXJ2-1]
DR Antibodypedia; 3361; 226 antibodies from 28 providers.
DR DNASU; 114905; -.
DR Ensembl; ENST00000295297.4; ENSP00000295297.4; ENSG00000163145.13. [Q9BXJ2-2]
DR Ensembl; ENST00000429690.5; ENSP00000410722.1; ENSG00000163145.13. [Q9BXJ2-1]
DR Ensembl; ENST00000444304.3; ENSP00000388914.2; ENSG00000163145.13. [Q9BXJ2-1]
DR GeneID; 114905; -.
DR KEGG; hsa:114905; -.
DR MANE-Select; ENST00000444304.3; ENSP00000388914.2; NM_031911.5; NP_114117.1.
DR UCSC; uc003gno.4; human. [Q9BXJ2-1]
DR CTD; 114905; -.
DR DisGeNET; 114905; -.
DR GeneCards; C1QTNF7; -.
DR HGNC; HGNC:14342; C1QTNF7.
DR HPA; ENSG00000163145; Low tissue specificity.
DR neXtProt; NX_Q9BXJ2; -.
DR OpenTargets; ENSG00000163145; -.
DR PharmGKB; PA25634; -.
DR VEuPathDB; HostDB:ENSG00000163145; -.
DR eggNOG; ENOG502R68F; Eukaryota.
DR GeneTree; ENSGT00940000159588; -.
DR HOGENOM; CLU_001074_0_3_1; -.
DR InParanoid; Q9BXJ2; -.
DR OrthoDB; 1258047at2759; -.
DR PhylomeDB; Q9BXJ2; -.
DR PathwayCommons; Q9BXJ2; -.
DR SignaLink; Q9BXJ2; -.
DR BioGRID-ORCS; 114905; 10 hits in 1059 CRISPR screens.
DR GenomeRNAi; 114905; -.
DR Pharos; Q9BXJ2; Tdark.
DR PRO; PR:Q9BXJ2; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q9BXJ2; protein.
DR Bgee; ENSG00000163145; Expressed in calcaneal tendon and 135 other tissues.
DR ExpressionAtlas; Q9BXJ2; baseline and differential.
DR Genevisible; Q9BXJ2; HS.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF01391; Collagen; 2.
DR PRINTS; PR00007; COMPLEMNTC1Q.
DR SMART; SM00110; C1Q; 1.
DR SUPFAM; SSF49842; SSF49842; 1.
DR PROSITE; PS50871; C1Q; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Collagen; Reference proteome; Secreted; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..289
FT /note="Complement C1q tumor necrosis factor-related protein
FT 7"
FT /id="PRO_0000003539"
FT DOMAIN 38..139
FT /note="Collagen-like"
FT DOMAIN 143..279
FT /note="C1q"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00368"
FT REGION 36..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..50
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..79
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1
FT /note="M -> MSRQEPKM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_046778"
SQ SEQUENCE 289 AA; 30683 MW; A61609FF86D26946 CRC64;
MFVLLYVTSF AICASGQPRG NQLKGENYSP RYICSIPGLP GPPGPPGANG SPGPHGRIGL
PGRDGRDGRK GEKGEKGTAG LRGKTGPLGL AGEKGDQGET GKKGPIGPEG EKGEVGPIGP
PGPKGDRGEQ GDPGLPGVCR CGSIVLKSAF SVGITTSYPE ERLPIIFNKV LFNEGEHYNP
ATGKFICAFP GIYYFSYDIT LANKHLAIGL VHNGQYRIKT FDANTGNHDV ASGSTVIYLQ
PEDEVWLEIF FTDQNGLFSD PGWADSLFSG FLLYVDTDYL DSISEDDEL
