C1QT7_MOUSE
ID C1QT7_MOUSE Reviewed; 289 AA.
AC Q8BVD7; Q8CHX9;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Complement C1q tumor necrosis factor-related protein 7;
DE Flags: Precursor;
GN Name=C1qtnf7; Synonyms=Ctrp7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; AK078818; BAC37409.1; -; mRNA.
DR EMBL; BC038308; AAH38308.1; -; mRNA.
DR CCDS; CCDS19262.1; -.
DR RefSeq; NP_001128644.1; NM_001135172.1.
DR RefSeq; NP_780634.2; NM_175425.4.
DR RefSeq; XP_006503728.1; XM_006503665.3.
DR AlphaFoldDB; Q8BVD7; -.
DR SMR; Q8BVD7; -.
DR STRING; 10090.ENSMUSP00000113520; -.
DR iPTMnet; Q8BVD7; -.
DR PhosphoSitePlus; Q8BVD7; -.
DR MaxQB; Q8BVD7; -.
DR PaxDb; Q8BVD7; -.
DR PRIDE; Q8BVD7; -.
DR ProteomicsDB; 281708; -.
DR Antibodypedia; 3361; 226 antibodies from 28 providers.
DR DNASU; 109323; -.
DR Ensembl; ENSMUST00000121872; ENSMUSP00000113520; ENSMUSG00000061535.
DR GeneID; 109323; -.
DR KEGG; mmu:109323; -.
DR UCSC; uc008xho.2; mouse.
DR CTD; 114905; -.
DR MGI; MGI:1925911; C1qtnf7.
DR VEuPathDB; HostDB:ENSMUSG00000061535; -.
DR eggNOG; ENOG502R68F; Eukaryota.
DR GeneTree; ENSGT00940000159588; -.
DR HOGENOM; CLU_001074_0_3_1; -.
DR InParanoid; Q8BVD7; -.
DR OrthoDB; 1258047at2759; -.
DR PhylomeDB; Q8BVD7; -.
DR TreeFam; TF329591; -.
DR BioGRID-ORCS; 109323; 4 hits in 72 CRISPR screens.
DR ChiTaRS; C1qtnf7; mouse.
DR PRO; PR:Q8BVD7; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q8BVD7; protein.
DR Bgee; ENSMUSG00000061535; Expressed in indifferent gonad and 120 other tissues.
DR ExpressionAtlas; Q8BVD7; baseline and differential.
DR Genevisible; Q8BVD7; MM.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0042802; F:identical protein binding; IPI:MGI.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF01391; Collagen; 2.
DR PRINTS; PR00007; COMPLEMNTC1Q.
DR SMART; SM00110; C1Q; 1.
DR SUPFAM; SSF49842; SSF49842; 1.
DR PROSITE; PS50871; C1Q; 1.
PE 2: Evidence at transcript level;
KW Collagen; Reference proteome; Secreted; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..289
FT /note="Complement C1q tumor necrosis factor-related protein
FT 7"
FT /id="PRO_0000003540"
FT DOMAIN 38..139
FT /note="Collagen-like"
FT DOMAIN 143..279
FT /note="C1q"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00368"
FT REGION 36..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..50
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..79
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 20
FT /note="A -> P (in Ref. 1; BAC37409)"
FT /evidence="ECO:0000305"
FT CONFLICT 193
FT /note="Y -> C (in Ref. 1; BAC37409)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 289 AA; 30517 MW; 45ED4E3C88E92CCB CRC64;
MIVLLYVTSL AICASGQPRA NQAKGESYSP RYICSIPGLP GPPGPPGANG SPGPHGRIGL
PGRDGRDGRK GEKGEKGTAG LKGKTGPLGL AGEKGDQGET GKKGPIGPEG EKGEVGPAGP
PGPKGDRGDQ GDPGLPGVCR CGSIVLKSAF SVGITTSYPE ERLPIIFNKV LFNEGEHYNP
ATGKFICAFP GIYYFSYDIT LANKHLAIGL VHNGQYRIRT FDANTGNHDV ASGSTVIYLQ
PEDEVWLEIF FNDQNGLFSD PGWADSLFSG FLLYVDTDYL DSISEDDEL
