C1RL_MOUSE
ID C1RL_MOUSE Reviewed; 482 AA.
AC Q3UZ09; Q3V019; Q7TT43; Q7TT44;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Complement C1r subcomponent-like protein;
DE Short=C1r-LP;
DE Short=C1r-like protein;
DE EC=3.4.21.-;
DE Flags: Precursor;
GN Name=C1rl; Synonyms=C1rlp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Ovary, Thymus, and Uterus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 27-482, AND NUCLEOTIDE SEQUENCE [GENOMIC DNA]
RP OF 168-482.
RC STRAIN=129/SvJ, and BALB/cJ; TISSUE=Liver;
RX PubMed=12686506; DOI=10.1016/s0161-5890(02)00283-3;
RA Circolo A., Garnier G., Volanakis J.E.;
RT "A novel murine complement-related gene encoding a C1r-like serum
RT protein.";
RL Mol. Immunol. 39:899-906(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 27-482.
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Mediates the proteolytic cleavage of HP/haptoglobin in the
CC endoplasmic reticulum. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed in liver (at protein level).
CC -!- SIMILARITY: Belongs to the peptidase S1 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00274}.
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DR EMBL; AK133495; BAE21686.1; -; mRNA.
DR EMBL; AK134207; BAE22052.1; -; mRNA.
DR EMBL; AF456427; AAP41416.1; -; Genomic_DNA.
DR EMBL; AF456428; AAP41417.1; -; mRNA.
DR EMBL; BC070472; AAH70472.1; -; mRNA.
DR CCDS; CCDS20520.1; -.
DR RefSeq; NP_851989.3; NM_181344.5.
DR AlphaFoldDB; Q3UZ09; -.
DR SMR; Q3UZ09; -.
DR STRING; 10090.ENSMUSP00000042883; -.
DR MEROPS; S01.189; -.
DR GlyGen; Q3UZ09; 1 site.
DR iPTMnet; Q3UZ09; -.
DR PhosphoSitePlus; Q3UZ09; -.
DR CPTAC; non-CPTAC-3429; -.
DR CPTAC; non-CPTAC-3895; -.
DR CPTAC; non-CPTAC-4018; -.
DR MaxQB; Q3UZ09; -.
DR PaxDb; Q3UZ09; -.
DR PeptideAtlas; Q3UZ09; -.
DR PRIDE; Q3UZ09; -.
DR ProteomicsDB; 273807; -.
DR Antibodypedia; 1734; 120 antibodies from 22 providers.
DR DNASU; 232371; -.
DR Ensembl; ENSMUST00000049124; ENSMUSP00000042883; ENSMUSG00000038527.
DR GeneID; 232371; -.
DR KEGG; mmu:232371; -.
DR UCSC; uc009dqy.2; mouse.
DR CTD; 51279; -.
DR MGI; MGI:2660692; C1rl.
DR VEuPathDB; HostDB:ENSMUSG00000038527; -.
DR eggNOG; KOG3627; Eukaryota.
DR GeneTree; ENSGT00940000162495; -.
DR HOGENOM; CLU_006842_0_0_1; -.
DR InParanoid; Q3UZ09; -.
DR OMA; NMFCVGD; -.
DR OrthoDB; 518015at2759; -.
DR PhylomeDB; Q3UZ09; -.
DR TreeFam; TF330373; -.
DR BioGRID-ORCS; 232371; 0 hits in 73 CRISPR screens.
DR PRO; PR:Q3UZ09; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q3UZ09; protein.
DR Bgee; ENSMUSG00000038527; Expressed in granulocyte and 41 other tissues.
DR GO; GO:0072562; C:blood microparticle; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0031638; P:zymogen activation; IBA:GO_Central.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.40.10.10; -; 2.
DR Gene3D; 2.60.120.290; -; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR033116; TRYPSIN_SER.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF49854; SSF49854; 1.
DR SUPFAM; SSF50494; SSF50494; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 1: Evidence at protein level;
KW Complement pathway; Disulfide bond; Glycoprotein; Hydrolase; Immunity;
KW Innate immunity; Protease; Reference proteome; Secreted; Serine protease;
KW Signal; Sushi.
FT SIGNAL 1..43
FT /evidence="ECO:0000255"
FT CHAIN 44..482
FT /note="Complement C1r subcomponent-like protein"
FT /id="PRO_0000318679"
FT DOMAIN 44..166
FT /note="CUB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 166..225
FT /note="Sushi"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 240..479
FT /note="Peptidase S1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT ACT_SITE 278
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 334
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 431
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT CARBOHYD 358
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..115
FT /evidence="ECO:0000250"
FT DISULFID 190..223
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 397..416
FT /evidence="ECO:0000250"
FT DISULFID 427..457
FT /evidence="ECO:0000250"
FT CONFLICT 58
FT /note="P -> T (in Ref. 1; BAE21686)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 482 AA; 53435 MW; 788DF1B5E012B453 CRC64;
MSGFRGLVPE LENSLWSSPT TSCMSKMCWW LLWGILHTCP TQASVLLAQQ SPQQLTSPGY
PEPYLKGQES HTDIEAPEGF AVRLTFQDFD LEPSPDCEGD SVTISTGGTD ATRLCGRQGS
PLGNPPGHRE FVSSGRSLRL TFQAHSSSKS KITHLHKGFL ALYQAVAVNQ PNGDTEAVTT
PGAPKIQNHC QDPYYKADQT GTLSCPSSWK WKDRQDGGEV PECVPVCGRP VVPLAENPNT
FGSSRAKLGN FPWQAFTSIY GRGGGALLGD RWILTAAHTI YPKDSIYLRR NQNVEVFLGH
TDIDELLKLG NHPVRRVVVH PDYRQHESHN FNGDIALLEL EQRVPLGPNL LPVCLPDNET
LYHSGLWGYV SGFGVEMGWL TTKLKYSKLP VAPREACEAW LHQRQRTEVF SDNMFCVGEE
MQVNSVCQGD SGSVYVVWDD LALRWVATGI VSWGIGCGKG YGFYTKVLSY MDWIKRVIEG
KD
