ID   ACBD4_BOVIN             Reviewed;         303 AA.
AC   Q2KHT9;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Acyl-CoA-binding domain-containing protein 4;
GN   Name=ACBD4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds medium- and long-chain acyl-CoA esters and may function
CC       as an intracellular carrier of acyl-CoA esters. {ECO:0000250}.
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DR   EMBL; BC112885; AAI12886.1; -; mRNA.
DR   RefSeq; NP_001039679.1; NM_001046214.1.
DR   AlphaFoldDB; Q2KHT9; -.
DR   SMR; Q2KHT9; -.
DR   STRING; 9913.ENSBTAP00000007953; -.
DR   PaxDb; Q2KHT9; -.
DR   PRIDE; Q2KHT9; -.
DR   Ensembl; ENSBTAT00000007953; ENSBTAP00000007953; ENSBTAG00000006054.
DR   GeneID; 515848; -.
DR   KEGG; bta:515848; -.
DR   CTD; 79777; -.
DR   VEuPathDB; HostDB:ENSBTAG00000006054; -.
DR   VGNC; VGNC:55767; ACBD4.
DR   eggNOG; KOG0817; Eukaryota.
DR   GeneTree; ENSGT00940000160739; -.
DR   HOGENOM; CLU_034436_1_0_1; -.
DR   InParanoid; Q2KHT9; -.
DR   OMA; LQVWAEQ; -.
DR   OrthoDB; 1546859at2759; -.
DR   TreeFam; TF319446; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000006054; Expressed in cortex of kidney and 105 other tissues.
DR   ExpressionAtlas; Q2KHT9; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0000062; F:fatty-acyl-CoA binding; IBA:GO_Central.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0006631; P:fatty acid metabolic process; IBA:GO_Central.
DR   CDD; cd00435; ACBP; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   InterPro; IPR022408; Acyl-CoA-binding_prot_CS.
DR   InterPro; IPR000582; Acyl-CoA-binding_protein.
DR   InterPro; IPR035984; Acyl-CoA-binding_sf.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   Pfam; PF00887; ACBP; 1.
DR   PRINTS; PR00689; ACOABINDINGP.
DR   SUPFAM; SSF47027; SSF47027; 1.
DR   PROSITE; PS00880; ACB_1; 1.
DR   PROSITE; PS51228; ACB_2; 1.
PE   2: Evidence at transcript level;
KW   Lipid-binding; Phosphoprotein; Reference proteome.
FT   CHAIN           1..303
FT                   /note="Acyl-CoA-binding domain-containing protein 4"
FT                   /id="PRO_0000247586"
FT   DOMAIN          12..101
FT                   /note="ACB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00573"
FT   REGION          148..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          191..224
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        155..169
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         23..32
FT                   /ligand="an acyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:58342"
FT                   /evidence="ECO:0000250"
FT   BINDING         43..47
FT                   /ligand="an acyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:58342"
FT                   /evidence="ECO:0000250"
FT   BINDING         69
FT                   /ligand="an acyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:58342"
FT                   /evidence="ECO:0000250"
FT   BINDING         88
FT                   /ligand="an acyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:58342"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         166
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NC06"
SQ   SEQUENCE   303 AA;  34440 MW;  78C94A603D8AA9B1 CRC64;
     MGIENESPEP DCQKQFQAAV SVIQNLPKNG SYRPSYEEML RFYSYYKQAT MGPCLIPQPG
     FWDPIGRYKW EAWNSLGQMS REEAMSAYIT EMKLVAQKVI DTVPLGEVAE DMFGYFEPLY
     QVIPDMPRPP ETFLRRVTGW KEQALNGDAE AAPEPPCLPK EPAPPSLESQ PPRDQDSEVF
     CDSVEQLEPE LVGEEQRGAL GGENDTRNSP EPPAEKGRLE GPLLGPQELD SWLVGTVRAL
     QDSMRDVQGR LQSLESMPMP PEQMPPPSAR PRPLRLSGPT LIFFLLWPFI VQWLFRQFRT
     QKR