ACBD4_HUMAN
ID ACBD4_HUMAN Reviewed; 268 AA.
AC Q8NC06; D3DX64; Q8IUT1; Q9H8Q4;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Acyl-CoA-binding domain-containing protein 4;
GN Name=ACBD4; ORFNames=HMFT0700;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Hepatoblastoma;
RX PubMed=15221005; DOI=10.1038/sj.onc.1207782;
RA Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S.,
RA Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S.,
RA Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.;
RT "Expression profiling and differential screening between hepatoblastomas
RT and the corresponding normal livers: identification of high expression of
RT the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas.";
RL Oncogene 23:5901-5911(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Ovary, and Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Brain, and Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166 AND SER-171, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [6]
RP X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 7-110 IN COMPLEX WITH THE
RP ACYL-COA STEAROYL-COENZYME A.
RG Structural genomics consortium (SGC);
RT "Crystal structure of human acyl-CoA binding domain 4.";
RL Submitted (APR-2009) to the PDB data bank.
CC -!- FUNCTION: Binds medium- and long-chain acyl-CoA esters and may function
CC as an intracellular carrier of acyl-CoA esters.
CC -!- INTERACTION:
CC Q8NC06-3; Q86V38: ATN1; NbExp=3; IntAct=EBI-12811089, EBI-11954292;
CC Q8NC06-3; P02489: CRYAA; NbExp=3; IntAct=EBI-12811089, EBI-6875961;
CC Q8NC06-3; G5E9A7: DMWD; NbExp=3; IntAct=EBI-12811089, EBI-10976677;
CC Q8NC06-3; P22607: FGFR3; NbExp=3; IntAct=EBI-12811089, EBI-348399;
CC Q8NC06-3; O14908-2: GIPC1; NbExp=3; IntAct=EBI-12811089, EBI-25913156;
CC Q8NC06-3; P06396: GSN; NbExp=3; IntAct=EBI-12811089, EBI-351506;
CC Q8NC06-3; Q92876: KLK6; NbExp=3; IntAct=EBI-12811089, EBI-2432309;
CC Q8NC06-3; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-12811089, EBI-5235340;
CC Q8NC06-3; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-12811089, EBI-750487;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8NC06-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NC06-2; Sequence=VSP_014089;
CC Name=3;
CC IsoId=Q8NC06-3; Sequence=VSP_014088, VSP_014090;
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DR EMBL; AB073387; BAD38638.1; -; mRNA.
DR EMBL; AK023384; BAB14553.1; -; mRNA.
DR EMBL; AK075104; BAC11403.1; -; mRNA.
DR EMBL; CH471178; EAW51550.1; -; Genomic_DNA.
DR EMBL; CH471178; EAW51551.1; -; Genomic_DNA.
DR EMBL; CH471178; EAW51552.1; -; Genomic_DNA.
DR EMBL; BC029164; AAH29164.1; -; mRNA.
DR EMBL; BC041143; AAH41143.1; -; mRNA.
DR CCDS; CCDS42348.1; -. [Q8NC06-2]
DR CCDS; CCDS45710.1; -. [Q8NC06-3]
DR CCDS; CCDS45711.1; -. [Q8NC06-1]
DR RefSeq; NP_001129177.1; NM_001135705.2. [Q8NC06-2]
DR RefSeq; NP_001129178.1; NM_001135706.2. [Q8NC06-3]
DR RefSeq; NP_001129179.1; NM_001135707.2. [Q8NC06-1]
DR RefSeq; NP_001308281.1; NM_001321352.1. [Q8NC06-3]
DR RefSeq; NP_001308282.1; NM_001321353.1. [Q8NC06-3]
DR RefSeq; NP_078998.1; NM_024722.3. [Q8NC06-2]
DR RefSeq; XP_016880577.1; XM_017025088.1. [Q8NC06-3]
DR RefSeq; XP_016880580.1; XM_017025091.1. [Q8NC06-2]
DR RefSeq; XP_016880581.1; XM_017025092.1. [Q8NC06-2]
DR PDB; 2WH5; X-ray; 2.60 A; A/B/C/D/E/F=7-110.
DR PDBsum; 2WH5; -.
DR AlphaFoldDB; Q8NC06; -.
DR SMR; Q8NC06; -.
DR BioGRID; 122878; 13.
DR IntAct; Q8NC06; 11.
DR iPTMnet; Q8NC06; -.
DR PhosphoSitePlus; Q8NC06; -.
DR BioMuta; ACBD4; -.
DR DMDM; 67460567; -.
DR EPD; Q8NC06; -.
DR jPOST; Q8NC06; -.
DR MassIVE; Q8NC06; -.
DR MaxQB; Q8NC06; -.
DR PeptideAtlas; Q8NC06; -.
DR PRIDE; Q8NC06; -.
DR ProteomicsDB; 72841; -. [Q8NC06-1]
DR ProteomicsDB; 72842; -. [Q8NC06-2]
DR ProteomicsDB; 72843; -. [Q8NC06-3]
DR Antibodypedia; 29971; 147 antibodies from 28 providers.
DR DNASU; 79777; -.
DR Ensembl; ENST00000321854.13; ENSP00000314440.8; ENSG00000181513.15. [Q8NC06-2]
DR Ensembl; ENST00000376955.8; ENSP00000366154.3; ENSG00000181513.15. [Q8NC06-1]
DR Ensembl; ENST00000398322.7; ENSP00000381367.2; ENSG00000181513.15. [Q8NC06-2]
DR Ensembl; ENST00000431281.5; ENSP00000405969.1; ENSG00000181513.15. [Q8NC06-3]
DR Ensembl; ENST00000586346.5; ENSP00000465484.1; ENSG00000181513.15. [Q8NC06-3]
DR Ensembl; ENST00000591859.5; ENSP00000465610.1; ENSG00000181513.15. [Q8NC06-3]
DR Ensembl; ENST00000619916.4; ENSP00000482750.1; ENSG00000181513.15. [Q8NC06-1]
DR GeneID; 79777; -.
DR KEGG; hsa:79777; -.
DR MANE-Select; ENST00000321854.13; ENSP00000314440.8; NM_001135705.3; NP_001129177.1. [Q8NC06-2]
DR UCSC; uc002iic.4; human. [Q8NC06-1]
DR CTD; 79777; -.
DR DisGeNET; 79777; -.
DR GeneCards; ACBD4; -.
DR HGNC; HGNC:23337; ACBD4.
DR HPA; ENSG00000181513; Tissue enhanced (liver).
DR neXtProt; NX_Q8NC06; -.
DR OpenTargets; ENSG00000181513; -.
DR PharmGKB; PA134897893; -.
DR VEuPathDB; HostDB:ENSG00000181513; -.
DR GeneTree; ENSGT00940000160739; -.
DR HOGENOM; CLU_034436_1_0_1; -.
DR InParanoid; Q8NC06; -.
DR OMA; LQVWAEQ; -.
DR OrthoDB; 1546859at2759; -.
DR PhylomeDB; Q8NC06; -.
DR TreeFam; TF319446; -.
DR PathwayCommons; Q8NC06; -.
DR Reactome; R-HSA-390918; Peroxisomal lipid metabolism.
DR SignaLink; Q8NC06; -.
DR BioGRID-ORCS; 79777; 25 hits in 1079 CRISPR screens.
DR ChiTaRS; ACBD4; human.
DR EvolutionaryTrace; Q8NC06; -.
DR GenomeRNAi; 79777; -.
DR Pharos; Q8NC06; Tdark.
DR PRO; PR:Q8NC06; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q8NC06; protein.
DR Bgee; ENSG00000181513; Expressed in right lobe of liver and 127 other tissues.
DR ExpressionAtlas; Q8NC06; baseline and differential.
DR Genevisible; Q8NC06; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0000062; F:fatty-acyl-CoA binding; IBA:GO_Central.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006631; P:fatty acid metabolic process; IBA:GO_Central.
DR CDD; cd00435; ACBP; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR InterPro; IPR022408; Acyl-CoA-binding_prot_CS.
DR InterPro; IPR000582; Acyl-CoA-binding_protein.
DR InterPro; IPR035984; Acyl-CoA-binding_sf.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR Pfam; PF00887; ACBP; 1.
DR PRINTS; PR00689; ACOABINDINGP.
DR SUPFAM; SSF47027; SSF47027; 1.
DR PROSITE; PS00880; ACB_1; 1.
DR PROSITE; PS51228; ACB_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Lipid-binding; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..268
FT /note="Acyl-CoA-binding domain-containing protein 4"
FT /id="PRO_0000214032"
FT DOMAIN 12..101
FT /note="ACB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00573"
FT REGION 151..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 23..32
FT /ligand="an acyl-CoA"
FT /ligand_id="ChEBI:CHEBI:58342"
FT BINDING 43..47
FT /ligand="an acyl-CoA"
FT /ligand_id="ChEBI:CHEBI:58342"
FT BINDING 69
FT /ligand="an acyl-CoA"
FT /ligand_id="ChEBI:CHEBI:58342"
FT BINDING 88
FT /ligand="an acyl-CoA"
FT /ligand_id="ChEBI:CHEBI:58342"
FT MOD_RES 166
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 171
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT VAR_SEQ 168..191
FT /note="ESHSPRDLDSEVFCDSLEQLEPEL -> ASLWAVTLPTPPQSPIHPGTWTPR
FT FSVIPWSSWSLSWFGQ (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15221005,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_014088"
FT VAR_SEQ 192..268
FT /note="SSGQHLEESVIPGTAPCPPQRKRGCGAARRGPRSWTCGCWGQFEHYRRACRR
FT CRRGCRAWRACPGPLSSLTLSVRLE -> VWTEQRAASGGKRDPRNSPVPPTKKEGLRG
FT SPPGPQELDVWLLGTVRALQESMQEVQARVQSLESMPRPPEQRPQPRPSARPWPLGLPG
FT PALLFFLLWPFVVQWLFRMFRTQKR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_014089"
FT VAR_SEQ 260..268
FT /note="SLTLSVRLE -> RGRSPGPVLGHGPLGSRGPRCSSSSCGPSSSSGSSECFG
FT PKRGDCQWRGLCSQLRLSCCALSLPRV (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15221005,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_014090"
FT VARIANT 118
FT /note="P -> L (in dbSNP:rs901754)"
FT /id="VAR_055478"
FT VARIANT 242
FT /note="R -> G (in dbSNP:rs16939879)"
FT /id="VAR_059109"
FT CONFLICT 166
FT /note="S -> G (in Ref. 2; BAC11403)"
FT /evidence="ECO:0000305"
FT HELIX 14..25
FT /evidence="ECO:0007829|PDB:2WH5"
FT HELIX 36..51
FT /evidence="ECO:0007829|PDB:2WH5"
FT HELIX 64..74
FT /evidence="ECO:0007829|PDB:2WH5"
FT TURN 75..78
FT /evidence="ECO:0007829|PDB:2WH5"
FT HELIX 81..100
FT /evidence="ECO:0007829|PDB:2WH5"
SQ SEQUENCE 268 AA; 30308 MW; 0F337D89924CDE2E CRC64;
MGTEKESPEP DCQKQFQAAV SVIQNLPKNG SYRPSYEEML RFYSYYKQAT MGPCLVPRPG
FWDPIGRYKW DAWNSLGKMS REEAMSAYIT EMKLVAQKVI DTVPLGEVAE DMFGYFEPLY
QVIPDMPRPP ETFLRRVTGW KEQVVNGDVG AVSEPPCLPK EPAPPSPESH SPRDLDSEVF
CDSLEQLEPE LSSGQHLEES VIPGTAPCPP QRKRGCGAAR RGPRSWTCGC WGQFEHYRRA
CRRCRRGCRA WRACPGPLSS LTLSVRLE
